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Sodium deoxycholate - 10mM in DMSO, high purity , CAS No.302-95-4

    Grade & Purity:
  • 10mM in DMSO
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Item Number
S423127
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S423127-1ml
1ml
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$76.90

Water-soluble ionic detergent for the solubilization of membrane-bound proteins.

Basic Description

Synonyms Sodium deoxycholate | Deoxycholic acid sodium salt | 302-95-4 | Sodium desoxycholate | Deoxycholate sodium | Desoxycholate sodium | Sodium 7-deoxycholate | Sodium deoxycholic acid | Deoxycholic acid, sodium salt | CHEBI:9177 | DTXSID5033389 | 436LS6U35Y | Kybella | NCGC00091038-01
Specifications & Purity 10mM in DMSO
Biochemical and Physiological Mechanisms Solubilizes fats for absorption in the intestines.Water-soluble ionic detergent useful for extraction of membrane receptors and other plasma membrane proteins. Reported to induce tyrosine phosphorylation of β-catenin and its subsequent translocation to th
Storage Temp Store at -80°C
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Product Description

Sodium deoxycholate is an ionic detergent for the solubilization of membrane-bound proteins. Deoxycholic Acid, Sodium Salt is reported to induce tyrosine phosphorylation of b-catenin and its subsequent translocation to the nucleus, promoting activation of β-catenin signaling (effective concentration 5-50 μM). Sodium deoxycholate is a bile salt and an ionic detergent. Bile salts work along with lipids/fats/cholesterol and form mixed micelles in the intestine. These micelles help in fat digestion and absorption through the intestinal wall
An ionic detergent for the solubilization of membrane-bound proteins.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Lipids and lipid-like molecules
Class Steroids and steroid derivatives
Subclass Bile acids, alcohols and derivatives
Intermediate Tree Nodes Hydroxy bile acids, alcohols and derivatives
Direct Parent Dihydroxy bile acids, alcohols and derivatives
Alternative Parents 3-alpha-hydroxysteroids  12-hydroxysteroids  Secondary alcohols  Cyclic alcohols and derivatives  Carboxylic acid salts  Monocarboxylic acids and derivatives  Carboxylic acids  Organic zwitterions  Organic sodium salts  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular Framework Aliphatic homopolycyclic compounds
Substituents Dihydroxy bile acid, alcohol, or derivatives - 3-hydroxysteroid - 12-hydroxysteroid - Hydroxysteroid - 3-alpha-hydroxysteroid - Cyclic alcohol - Carboxylic acid salt - Secondary alcohol - Carboxylic acid derivative - Carboxylic acid - Organic alkali metal salt - Monocarboxylic acid or derivatives - Organic sodium salt - Hydrocarbon derivative - Alcohol - Organic oxide - Organic oxygen compound - Organic salt - Carbonyl group - Organooxygen compound - Organic zwitterion - Aliphatic homopolycyclic compound
Description This compound belongs to the class of organic compounds known as dihydroxy bile acids, alcohols and derivatives. These are compounds containing or derived from a bile acid or alcohol, and which bears exactly two carboxylic acid groups.
External Descriptors bile acid salt

Associated Targets(Human)

NR3C1 Tclin Glucocorticoid receptor (14987 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RXRA Tclin Retinoid X receptor alpha (3637 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GSTO1 Tchem Glutathione transferase omega 1 (164 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Lymphoblastoid cell (5959 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Cruzipain (33337 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Ppard Peroxisome proliferator-activated receptor delta (358 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name sodium;(4R)-4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate
INCHI InChI=1S/C24H40O4.Na/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3;/h14-21,25-26H,4-13H2,1-3H3,(H,27,28);/q;+1/p-1/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-;/m1./s1
InChIKey FHHPUSMSKHSNKW-SMOYURAASA-M
Smiles CC(CCC(=O)[O-])C1CCC2C1(C(CC3C2CCC4C3(CCC(C4)O)C)O)C.[Na+]
Isomeric SMILES C[C@H](CCC(=O)[O-])[C@H]1CC[C@@H]2[C@@]1([C@H](C[C@H]3[C@H]2CC[C@H]4[C@@]3(CC[C@H](C4)O)C)O)C.[Na+]
WGK Germany 3
RTECS FZ2250000
PubChem CID 23668196
Molecular Weight 414.56
Beilstein 3581950

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Chemical and Physical Properties

Sensitivity Hygroscopic
Specific Rotation[α] 42° (C=2,H2O)
Molecular Weight 414.600 g/mol
XLogP3
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 4
Rotatable Bond Count 4
Exact Mass 414.275 Da
Monoisotopic Mass 414.275 Da
Topological Polar Surface Area 80.600 Ų
Heavy Atom Count 29
Formal Charge 0
Complexity 612.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 10
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 2

Citations of This Product

1. Jing Zhang, Kairu Liu, Xiaojuan Duan, Xuhao Wang, Wupeng Ge, Wenping Jin.  (2023)  Restoration of Choujiu Koji and evaluation of its brewing performance.  LWT-FOOD SCIENCE AND TECHNOLOGY,  183  (114933). 
2. Peng Weichao, Yan Shuaihu, Zhou Ke, Wu Hai-Chen, Liu Lei, Zhao Yuliang.  (2023)  High-resolution discrimination of homologous and isomeric proteinogenic amino acids in nanopore sensors with ultrashort single-walled carbon nanotubes.  Nature Communications,  14  (1): (1-8). 
3. Sheng Liu, Bo Yang, Yingxiang Hou, Kaige Cui, Xiaozhu Yang, Xiaoxiong Li, Lianwan Chen, Shichao Liu, Zhichao Zhang, Yuanyuan Jia, Yufeng Xie, Ying Xue, Xiaomei Li, Bingxue Yan, Changxin Wu, Wen Deng, Jianxun Qi, Defen Lu, George F. Gao, Peiyi Wang, Guijun Shang.  (2023)  The mechanism of STING autoinhibition and activation.  MOLECULAR CELL,  83  (1502-1518.e10). 
4. Qin Guo, Jie Cai, Pengyu Li, Dongling Xu, Xiaomin Ni, Hui Wen, Dan Liu, Suizhen Lin, Haiyan Hu.  (2023)  Comparison of bile salt/phosphatidylcholine mixed micelles in solubilization to sterols and stability.  Drug Design Development and Therapy,     
5. Chuntian Shao, Jingwei Zhong, Junwen Liu, Yiyan Yang, Meilin Li, Yang Yu, Yaqin Xu, Libo Wang.  (2023)  Preparation, characterization and bioactivities of selenized polysaccharides from Lonicera caerulea L. fruits.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  225  (484). 
6. Shuo Qi, Xiaoze Dong, Yuhan Sun, Yin Zhang, Nuo Duan, Zhouping Wang.  (2022)  Split aptamer remodeling-initiated target-self-service 3D-DNA walker for ultrasensitive detection of 17β-estradiol.  JOURNAL OF HAZARDOUS MATERIALS,  439  (129590). 
7. Ping Li, Yiting Yang, Zijin Lin, Shijin Hong, Ling Jiang, Han Zhou, Lu Yang, Liang Zhu, Xiaodong Liu, Li Liu.  (2022)  Bile Duct Ligation Impairs Function and Expression of Mrp1 at Rat Blood–Retinal Barrier via Bilirubin-Induced P38 MAPK Pathway Activations.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  23  (14): (7666). 
8. Wang Cong-Yu, Sun Min, Fan Zhen, Du Jian-Zhong.  (2022)  Intestine Enzyme-responsive Polysaccharide-based Hydrogel to Open Epithelial Tight Junctions for Oral Delivery of Imatinib against Colon Cancer.  CHINESE JOURNAL OF POLYMER SCIENCE,  40  (10): (1154-1164). 
9. Chu-tong Tian, Jing-jing Guo, Yi-fan Miao, He-lin Wang, Qing Ye, Chun-lin Guo, Ming-yang Zhang, Zhong-gui He, Jin Sun.  (2022)  Long chain triglyceride-lipid formulation promotes the oral absorption of the lipidic prodrugs through coincident intestinal behaviors.  EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS,  176  (122). 
10. Zhang Pengpeng, Zhang Miaomiao, Dong Kaiyu, Zhang Yicong, Yang Shuang, Wang Yuanhong, Jiang Tingfu, Yu Mingming, Lv Zhihua.  (2022)  Evaluation of Chito-Oligosaccharide (COS) in Vitro and in Vivo: Permeability Characterization in Caco-2 Cells Monolayer and Pharmacokinetics Properties in Rats.  Journal of Ocean University of China,  21  (3): (782-788). 
11. Yu Luo, Shenyu Huang, Lie Ma.  (2021)  A novel detergent-based decellularization combined with carbodiimide crosslinking for improving anti-calcification of bioprosthetic heart valve.  Biomedical Materials,  16  (4): (45022). 
12. Yang Min, Lu Xiaoluan, Tang Luyang, Fu Yangyang, Yang Peixin.  (2020)  Thermosensitive nanocomposite gel loaded zinc phthalocyanine for photodynamic therapy.  JOURNAL OF POLYMER RESEARCH,  27  (9): (1-10). 
13. Xinrui Li, Jing Su, Zul Kamal, Pengcheng Guo, Xinyi Wu, Lina Lu, Hongbing Wu, Mingfeng Qiu.  (2020)  Odorranalectin modified PEG–PLGA/PEG–PBLG curcumin-loaded nanoparticle for intranasal administration.  DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY,  46  (6): (899-909). 
14. Zhou Xueqing, Xie Yanli, Zhao Zhendong, Fu Wenyan.  (2020)  A simple strategy based on fibers coated with surfactant-functionalized multiwalled carbon nanotubes to improve the properties of solid-phase microextraction of phenols in aqueous solution.  BMC Chemistry,  14  (1): (1-11). 
15. Xuejuan Zhang, Xiao Yue, Yingtong Cui, Ziyu Zhao, Ying Huang, Shihao Cai, Guanlin Wang, Wenhao Wang, Smyth Hugh, Xin Pan, Chuanbin Wu, Wen Tan.  (2020)  A Systematic Safety Evaluation of Nanoporous Mannitol Material as a Dry-Powder Inhalation Carrier System.  JOURNAL OF PHARMACEUTICAL SCIENCES,  109  (1692). 
16. Xiaoluan Lu, Wentao Zhu, Tingyu Chen, Qianrong Peng, Changmu Yu, Min Yang.  (2019)  Exploration of photophysical and photochemical properties of Zinc phthalocyanine-loaded SDC/TPGS mixed micelles.  CHEMICAL PHYSICS LETTERS,  735  (136737). 
17. Xu Yingxin, Fang Tianxu, Yang Yifan, Sun Li’ang, Shen Qi.  (2019)  Preparation of Deoxycholate-Modified Docetaxel-Cimetidine Complex Chitosan Nanoparticles to Improve Oral Bioavailability.  AAPS PHARMSCITECH,  20  (7): (1-10). 
18. Hailing Yang, Zhenjie Liu, Yonglong Song, Changjiang Hu.  (2019)  Hyaluronic acid-functionalized bilosomes for targeted delivery of tripterine to inflamed area with enhancive therapy on arthritis.  DRUG DELIVERY,  26  (1): (820-830). 
19. Hui Li, Yang Pang, Xin Wang, Xun Cao, Xun He, Kequan Chen, Ganlu Li, Pingkai Ouyang, Weiming Tan.  (2019)  Phospholipase D encapsulated into metal-surfactant nanocapsules for enhancing biocatalysis in a two-phase system.  RSC Advances,  (12): (6548-6555). 
20. Hui Li, Yan Ni, Xun Cao, Xun He, Ganlu Li, Kequan Chen, Pingkai Ouyang, Jianming Yang, Weiming Tan.  (2019)  Highly active nanobiocatalysis in deep eutectic solvents via metal-driven enzyme-surfactant nanocomposite.  JOURNAL OF BIOTECHNOLOGY,  292  (39). 
21. Li Zhang, Dandan Ren, Jianyu Zhou, Guangneng Peng, Gang Shu, Zhixiang Yuan, Fei Shi, Ling Zhao, Lizi Yin, Guoqing Fan, Chang Liu, Hualin Fu.  (2018)  Toltrazuril mixed nanomicelle delivery system based on sodium deoxycholate–Brij C20 polyethylene ether–triton x100: Characterization, solubility, and bioavailability study.  COLLOIDS AND SURFACES B-BIOINTERFACES,  163  (125). 
22. Weihua Jiang, Ju Wang, Lei Yang, Xuewei Jiang, Zhaoshi Bai, Zheran Wang, Yunpeng He, Dongkai Wang.  (2015)  Nanostructured lipid carriers modified with PEGylated carboxymethylcellulose polymers for effective delivery of docetaxel.  RSC Advances,  (110): (90386-90395). 
23. Xuesong Kong, Shixiang Feng, Xu Zhang, Yan Li.  (2014)  Effects of bile salts and divalent cations on the adsorption of norfloxacin by agricultural soils.  Journal of Environmental Sciences,  26  (846). 
24. Ni Li, Li-Hua Peng, Xi Chen, Shinsaku Nakagawa, Jian-Qing Gao.  (2011)  Effective transcutaneous immunization by antigen-loaded flexible liposome in vivo.  International Journal of Nanomedicine,  ( 3241–3250). 
25. Chuan Niu, Tian Liu, Liping Yang, Dan Wang, Xiong Xiao, Shaojie Yang, Ziwei Huang, Yuchu Yang, Li Feng.  (2025)  Bifunctional sheets reduce the microbe and endotoxin contamination of tissue-derived collagen.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,    (141411). 
26. Luo Juan, Yu Yao, Wang Ke, He Sizhe, Wang Longjie, Liang Fangfang, Chin Jason W., Tang Shan.  (2024)  Capturing acyl–enzyme intermediates with genetically encoded 2,3-diaminopropionic acid for hydrolase substrate identification.  Nature Protocols,    (1-33). 
27. Hujun Xie, Xin Luo, Ying Gao, Min Huang, Gerui Ren, Rongmi Zhou, Yulu Sun, Haoxin Ye, Qunfang Lei, Wenjun Fang, Yong-Quan Xu.  (2024)  Co-encapsulation of Lactobacillus plantarum and EGCG: A promising strategy to increase the stability and lipid-lowering activity.  FOOD HYDROCOLLOIDS,  151  (109768). 
28. Xinyuan Yan, Juan Chai, Luohao Yuan, Hongfeng Yin.  (2024)  Construction of Pt-GOx@H-ZIF-8 core–shell structure for the detection of glutathione.  MICROCHEMICAL JOURNAL,  200  (110384). 
29. Guanliang He, Chuang Zhu, Yuze Shi, Yingjia Yu, Yi Wu, Constantinos Soutis, Le Cao, Xuqing Liu.  (2024)  Development of a Mussel-Inspired Conductive Graphene Coated Cotton Yarn for Wearable Sensors.  iScience,    (111711). 
30. Wang Wenchao, An Lianhao, Lei Junrong, Li Dan, Shen Zheluan, Wang Hong, Li Qingyong.  (2024)  Effects of Different Extraction Methods on Biological Activities of Pearl Powder Extracts.  Chemistry Africa-A Journal of the Tunisian Chemical Society,    (1-12). 
31. Wenzhu Kuang, Hongxia Luo, Zhiwei Zhu.  (2024)  Exploring the potential of inherent chiral single-walled carbon nanotubes in enantioselective electrochemical sensing: A novel microsensor for discriminating DOPA enantiomers.  ELECTROCHIMICA ACTA,  487  (144162). 
32. Nanting Zhu, Decheng Bi, Jinfeng Huang, Lijun Yao, Yan Wu, Zedong Jiang, Zhangli Hu, Beiwei Zhu, Shuangfei Li, Xu Xu.  (2025)  Genipin crosslinked sodium caseinate-chitosan oligosaccharide nanoparticles for optimizing β-carotene stability and bioavailability.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,    (139626). 
33. Yingjie Du, Xiuyan Luo, Xiaohong Ye, Meijia Song, Yingjia Li, Shumao Yang, Caoxing Huang, Jiandong Cui.  (2025)  Molecular imprinted photoresponse hybrid biocatalyst for ultrasensitive glutamate detection.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  308  (142540). 
34. Chen Xianghang, Wang Beini, Al Mamun Abdullah, Du Kaiyi, Wang Shengfu, Hu Qianqian, Chen Xinyuan, Lu Yang, Du Anyu, Wu Yueqi, Shao Jiaqin, Wang Shuangshuang, Jiang Chang, Zhou Kailiang, Hu Siwang, Xiao Jian.  (2025)  Pectin-Zein-IPA nanoparticles promote functional recovery and alleviate neuroinflammation after spinal cord injury.  JOURNAL OF NANOBIOTECHNOLOGY,  23  (1): (1-18). 
35. Xi Luo, Litian Zhang, Xiaoyuan Xie, Liyan Yuan, Yanqiang Shi, Yinbo Jiang, Wujian Ke, Bin Yang.  (2024)  Phosphorylated vimentin-triggered fibronectin matrix disaggregation enhances the dissemination of Treponema pallidum subsp. pallidum across the microvascular endothelial barrier.  PLoS Pathogens,  20  (9): (e1012483). 
36. Xin Tan, Yi Zhou, Yaxin Qin, Linjie Wu, Ruizhi Yang, Xiaoyan Bao, Ruolin Jiang, Xiaoyan Sun, Xufang Ying, Zhiqing Ben, Qi Dai, Zhicheng Zhang, Kai Zeng, Min Han.  (2024)  Self-Healing Hydrogel Resulting from the Noncovalent Interaction between Ropivacaine and Low-Molecular-Weight Gelator Sodium Deoxycholate Achieves Stable and Endurable Local Analgesia in Vivo.  ACS Applied Materials & Interfaces,     
37. Faisal Raza, Liangdi Jiang, Shulei Zhang, Hajra Zafar, Yujiao Qiu, Jing Su, Mingfeng Qiu.  (2024)  SP94 engineered erythrocyte membrane enhanced the targeted delivery of biomimetic nanosuspension with IDO immunotherapy and chemotherapy in liver cancer.  CHEMICAL ENGINEERING JOURNAL,    (151709). 
38. Jin Wang, Jie Li, Xiao Luo, Mei-Mei Qu Mo, Jing Feng, Wen-Bing Li, Huiling Yan, Yi-Chen Hu, Liang Zou, Ding-Tao Wu.  (2024)  Structural properties and biological effects of pectic polysaccharides extracted from Tartary buckwheat sprouts by high pressure-assisted deep eutectic solvent extraction.  LWT-FOOD SCIENCE AND TECHNOLOGY,  203  (116397). 
39. Te Yu, Yonggang Dai, Zifei Wang, Yang Gao, Qiong Wu.  (2025)  Ultrasound-induced modifications of Auricularia auricula polysaccharides: Implications for antioxidant and glucose-lowering activities.  Food Chemistry-X,  25  (102209). 

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