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SF1670 - ≥98%, high purity , CAS No.345630-40-2

    Grade & Purity:
  • ≥98%
In stock
Item Number
S275771
Grouped product items
SKU Size
Availability
Price Qty
S275771-5mg
5mg
2
$117.90
S275771-25mg
25mg
2
$343.90
S275771-100mg
100mg
2
$984.90

Selective PTEN inhibitor

Basic Description

Synonyms CS-6115 | N-(9,10-dioxo-9,10-dihydrophenanthren-2-yl)pivalamide | N-(9,10-dihydro-9,10-dioxophenanthren-7-yl)pivalamide | CCG-267547 | Histidine, monohydrochloride, monohydrate | HY-15842 | N-(9,10-dihydro-9,10-dioxophethren-7-yl)pivalamide | Protein Tyro
Specifications & Purity ≥98%
Storage Temp Store at 2-8°C,Desiccated
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Product introduction

SF1670 is a potent and specific phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor


Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.


Application

SF1670 has been used:

• To study the effect of microRNA-30a on PTEN (phosphatase and tensin homologue deleted on chromosome 10 ) expression regulation.

• To study the formation of autophagosomes, induced by EGF (Epidermal growth factor) - dependent PTEN expression.

• To study the role of PTEN in the regulation of autophagy induction in human normal endometrial stromal cells.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Benzenoids
Class Phenanthrenes and derivatives
Subclass Phenanthraquinones
Intermediate Tree Nodes Not available
Direct Parent Phenanthraquinones
Alternative Parents Hydrophenanthrenes  Naphthalenes  O-quinones  N-arylamides  Aryl ketones  Secondary carboxylic acid amides  Organic oxides  Hydrocarbon derivatives  
Molecular Framework Aromatic homopolycyclic compounds
Substituents Phenanthraquinone - Hydrophenanthrene - Naphthalene - O-quinone - Quinone - N-arylamide - Aryl ketone - Ketone - Secondary carboxylic acid amide - Carboxamide group - Carboxylic acid derivative - Carbonyl group - Organic oxide - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Aromatic homopolycyclic compound
Description This compound belongs to the class of organic compounds known as phenanthraquinones. These are phenanthrene derivatives containing two ketone groups at position C9 and C10, respectively.
External Descriptors Not available

Associated Targets(Human)

CTSL Tclin Cathepsin L1 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
CTSS Tchem Cathepsin S (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
PTPRC Tchem Receptor-type tyrosine-protein phosphatase C (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
VDR Tclin Vitamin D receptor (26531 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
LCK Tclin Tyrosine-protein kinase LCK (9212 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CTSB Tchem Cathepsin B (3822 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CTSS Tchem Cathepsin S (3285 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PTPN13 Tchem Protein-tyrosine phosphatase 1E (88 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PTPRC Tchem Leukocyte common antigen (2317 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
FEN1 Tchem Flap endonuclease 1 (12055 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
POLI Tchem DNA polymerase iota (116820 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GALK1 Tbio Galactokinase (959 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (40980 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

CTSL Cathepsin L (58 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Ptpn1 Protein-tyrosine phosphatase 1B (270 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504765103
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504765103
IUPAC Name N-(9,10-dioxophenanthren-2-yl)-2,2-dimethylpropanamide
INCHI InChI=1S/C19H17NO3/c1-19(2,3)18(23)20-11-8-9-13-12-6-4-5-7-14(12)16(21)17(22)15(13)10-11/h4-10H,1-3H3,(H,20,23)
InChIKey VZQDDSYKVYARDW-UHFFFAOYSA-N
Smiles CC(C)(C)C(=O)NC1=CC2=C(C=C1)C3=CC=CC=C3C(=O)C2=O
Isomeric SMILES CC(C)(C)C(=O)NC1=CC2=C(C=C1)C3=CC=CC=C3C(=O)C2=O
PubChem CID 9926586
Molecular Weight 307.35

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number Certificate Type Date Item
L2403058 Certificate of Analysis Dec 09, 2024 S275771
I2202871 Certificate of Analysis Jun 13, 2023 S275771
I2202847 Certificate of Analysis Jun 13, 2023 S275771
I2202856 Certificate of Analysis Jun 13, 2023 S275771

Chemical and Physical Properties

Solubility Soluble in DMSO to 100 mM
Molecular Weight 307.300 g/mol
XLogP3 3.100
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 3
Rotatable Bond Count 2
Exact Mass 307.121 Da
Monoisotopic Mass 307.121 Da
Topological Polar Surface Area 63.200 Ų
Heavy Atom Count 23
Formal Charge 0
Complexity 519.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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