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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab209774-100μg
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100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$109.90
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Ab209774-1mg
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1mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$509.90
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Ab209774-5mg
|
5mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$1,399.90
|
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Ab209774-10mg
|
10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$2,299.90
|
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Purity≥95% (SDS-PAGE&SEC-HPLC); Endotoxin Level<1.0 EU/mg; Human IgG4SP; CHO; ELISA, Flow Cytometry, Functional assay, Animal Model; Unconjugated
| Product Name | Regeneron patent anti-TIE-2 (anti-TIE2) - Primary antibody, specific to TEK |
|---|---|
| Synonyms | Angiopoietin 1 receptor antibody | Angiopoietin-1 receptor antibody | CD202b antibody | CD202b antigen antibody | Endothelial tyrosine kinase antibody | Endothelium specific receptor tyrosine kinase 2 antibody | hTIE 2 antibody | hTIE2 antibody | Hyk anti |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Biochemical and Physiological Mechanisms | Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maint |
| Host species | Human |
| Specificity | TEK |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Product Description |
Regeneron patent anti-TIE-2 (anti-TIE2) is a fully human monoclonal antibody that binds to human Tie2 and blocks the interaction between Tie2 or Tie2 ligands (angiopoietin). It has the potential to treat angiogenesis disorders. |
| Light Chain Type | kappa |
|---|---|
| SDS-PAGE | 150 kDa |
| Purification Method | Protein A purified |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Regeneron patent anti-TIE-2 (anti-TIE2) (Ab209774) - ELISA
Immobilized Recombinant HUTIE2- ECD-gsvo-HUFC protein at 2.0 μg/mL can bind Regeneron patent anti-TIE-2 (anti-TIE2) (Ab209774), with the EC50 of 503.5 ng/mL.
Regeneron patent anti-TIE-2 (anti-TIE2) (Ab209774) - SEC
The purity of Regeneron patent anti-TIE-2 (anti-TIE2) (Ab209774) is more than 95% verified by HPLC.