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R788 (Fostamatinib) Disodium - ≥98%, high purity , CAS No.1025687-58-4

COA

Grade & Purity:

≥98%

Cas Number: 1025687-58-4
Molecular Weight: 624.42
PubChem CID: 25008120
PubChem SID: 504769930

In stock

Item Number

R129913

Grouped product items
SKU	Size	Availability	Price
R129913-1mg	1mg	3	$48.90
R129913-5mg	5mg	3	$103.90
R129913-10mg	10mg	2	$155.90
R129913-25mg	25mg	2	$351.90
R129913-50mg	50mg	2	$469.90
R129913-100mg	100mg	2	$770.90

View related series

FLT3 (103) Non-receptor Tyrosine Kinase (643) Protein Tyrosine Kinase/RTK (1314) Receptor Tyrosine Kinase (1260) Syk (36)

Basic Description

Synonyms	CCG-270264 \| R788 disodium (Fostamatinib) \| 1025687-58-4 \| FosD \| R788(Fostamatinib disodium) \| 2H-Pyrido(3,2-b)-1,4-oxazin-3(4H)-one, 6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)-4-pyrimidinyl)amino)-2,2-dimethyl-4-((phosphonooxy)methyl)-, sodium salt
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	R788 (Fostamatinib) is an important spleen tyrosine kinase (Syk) inhibitor, showing efficacy against kinase-mediated IgG Fc gamma receptor signaling. R788 inhibits the activation of mast cells, macrophages, and B-cells and related inflammatory responses a
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	R788 (Fostamatinib) disodium, a prodrug of the active metabolite R406, is a Syk inhibitor with IC50 of 41 nM, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. Phase 3. An inhibitor to spleenic kinase-mediated IgG Fc receptor signaling.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Benzene and substituted derivatives
    - Subclass Aniline and substituted anilines

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	Aniline and substituted anilines
Intermediate Tree Nodes	Not available
Direct Parent	Methoxyanilines
Alternative Parents	Phenoxy compounds Methoxybenzenes Anisoles Alkyl aryl ethers Aminopyridines and derivatives Aminopyrimidines and derivatives Halopyrimidines Alkyl phosphates Imidolactams Aryl fluorides Tertiary carboxylic acid amides Heteroaromatic compounds Lactams Oxacyclic compounds Organic metal halides Azacyclic compounds Carbonyl compounds Hydrocarbon derivatives Organic oxides Organic sodium salts Amines Organic zwitterions Organofluorides
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Methoxyaniline - Phenol ether - Phenoxy compound - Methoxybenzene - Anisole - Alkyl aryl ether - Aminopyridine - Halopyrimidine - Aminopyrimidine - Alkyl phosphate - Pyrimidine - Organic phosphoric acid derivative - Imidolactam - Pyridine - Phosphoric acid ester - Aryl halide - Aryl fluoride - Tertiary carboxylic acid amide - Heteroaromatic compound - Lactam - Carboxamide group - Organic metal halide - Oxacycle - Azacycle - Carboxylic acid derivative - Ether - Organic alkali metal salt - Organoheterocyclic compound - Organic sodium salt - Organic oxide - Organic nitrogen compound - Organic oxygen compound - Carbonyl group - Amine - Organohalogen compound - Hydrocarbon derivative - Organofluoride - Organonitrogen compound - Organooxygen compound - Organic salt - Organic zwitterion - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as methoxyanilines. These are organic compound containing an aniline group substituted at one or more positions by a methoxy group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

Pubchem Sid	504769930
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504769930
IUPAC Name	disodium;[6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-3-oxopyrido[3,2-b][1,4]oxazin-4-yl]methyl phosphate
INCHI	InChI=1S/C23H26FN6O9P.2Na/c1-23(2)21(31)30(11-38-40(32,33)34)20-14(39-23)6-7-17(28-20)27-19-13(24)10-25-22(29-19)26-12-8-15(35-3)18(37-5)16(9-12)36-4;;/h6-10H,11H2,1-5H3,(H2,32,33,34)(H2,25,26,27,28,29);;/q;2*+1/p-2
InChIKey	HSYBQXDGYCYSGA-UHFFFAOYSA-L
Smiles	CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)([O-])[O-])C.[Na+].[Na+]
Isomeric SMILES	CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)([O-])[O-])C.[Na+].[Na+]
PubChem CID	25008120
Molecular Weight	624.42

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot Number	Certificate Type	Date	Item
C2308851	Certificate of Analysis	Dec 10, 2024	R129913
C2308849	Certificate of Analysis	Dec 10, 2024	R129913
C2308852	Certificate of Analysis	Dec 10, 2024	R129913
C2308850	Certificate of Analysis	Dec 10, 2024	R129913
C2308882	Certificate of Analysis	Dec 10, 2024	R129913
C2308853	Certificate of Analysis	Dec 10, 2024	R129913

Chemical and Physical Properties

Solubility	Soluble in DMSO (0.4 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), and 0.5% CMC/0.25% Tween 80,pH6.5 (30 mg/ml at 25 °C).
Sensitivity	Moisture sensitive
Melt Point(°C)	>191°C (dec.)
Molecular Weight	624.400 g/mol
XLogP3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	15
Rotatable Bond Count	9
Exact Mass	624.112 Da
Monoisotopic Mass	624.112 Da
Topological Polar Surface Area	192.000 Å²
Heavy Atom Count	42
Formal Charge	0
Complexity	893.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	3

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