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Protein Tyrosine Kinase/RTK
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Fostamatinib Disodium Hexahydrate - 98%, high purity , Tyrosine-protein kinase SYK inhibitor, CAS No.914295-16-2, Tyrosine-protein kinase SYK inhibitor

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Fostamatinib Disodium Hexahydrate - 98%, high purity , Tyrosine-protein kinase SYK inhibitor, CAS No.914295-16-2, Tyrosine-protein kinase SYK inhibitor

COA

Grade & Purity:

≥98%

Cas Number: 914295-16-2
Molecular Weight: 732.51
PubChem CID: 24828759
PubChem SID: 488200699

In stock

Item Number

F336802

Grouped product items
SKU	Size	Availability	Price
F336802-1mg	1mg	3	$22.90
F336802-5mg	5mg	4	$94.90
F336802-25mg	25mg	2	$261.90
F336802-50mg	50mg	1	$426.90
F336802-100mg	100mg	1	$699.90

View related series

FLT3 (103) Non-receptor Tyrosine Kinase (643) Protein Tyrosine Kinase/RTK (1314) Receptor Tyrosine Kinase (1260) Syk (36)

Basic Description

Synonyms	Fostamatinib disodium \| Fostamatinib disodium [USAN] \| Fostamatinib disodium hexahydrate \| R-935788 \| Tamatinib fosdium \| Disulfoton [BSI:ISO] \| R935788 SODIUM HYDRATE \| R-935788 SODIUM HYDRATE \| 86EEZ49YVB \| Fostamatinib disodium (USAN) \| Sodium (6-((5-f
Specifications & Purity	≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Action Type	INHIBITOR
Mechanism of action	Tyrosine-protein kinase SYK inhibitor

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Benzene and substituted derivatives
    - Subclass Aniline and substituted anilines

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	Aniline and substituted anilines
Intermediate Tree Nodes	Not available
Direct Parent	Methoxyanilines
Alternative Parents	Phenoxy compounds Methoxybenzenes Anisoles Alkyl aryl ethers Aminopyridines and derivatives Aminopyrimidines and derivatives Halopyrimidines Alkyl phosphates Imidolactams Aryl fluorides Tertiary carboxylic acid amides Heteroaromatic compounds Lactams Oxacyclic compounds Organic metal halides Azacyclic compounds Carbonyl compounds Hydrocarbon derivatives Organic oxides Organic sodium salts Amines Organic zwitterions Organofluorides
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Methoxyaniline - Phenol ether - Phenoxy compound - Methoxybenzene - Anisole - Alkyl aryl ether - Aminopyridine - Halopyrimidine - Aminopyrimidine - Alkyl phosphate - Pyrimidine - Organic phosphoric acid derivative - Imidolactam - Pyridine - Phosphoric acid ester - Aryl halide - Aryl fluoride - Tertiary carboxylic acid amide - Heteroaromatic compound - Lactam - Carboxamide group - Organic metal halide - Oxacycle - Azacycle - Carboxylic acid derivative - Ether - Organic alkali metal salt - Organoheterocyclic compound - Organic sodium salt - Organic oxide - Organic nitrogen compound - Organic oxygen compound - Carbonyl group - Amine - Organohalogen compound - Hydrocarbon derivative - Organofluoride - Organonitrogen compound - Organooxygen compound - Organic salt - Organic zwitterion - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as methoxyanilines. These are organic compound containing an aniline group substituted at one or more positions by a methoxy group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

SYK Tclin Tyrosine-protein kinase SYK (7372 Activities)

Discover Target: SYK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDR Tclin Vascular endothelial growth factor receptor 2 (20924 Activities)

Discover Target: KDR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488200699
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488200699
IUPAC Name	disodium;[6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-3-oxopyrido[3,2-b][1,4]oxazin-4-yl]methyl phosphate;hexahydrate
INCHI	InChI=1S/C23H26FN6O9P.2Na.6H2O/c1-23(2)21(31)30(11-38-40(32,33)34)20-14(39-23)6-7-17(28-20)27-19-13(24)10-25-22(29-19)26-12-8-15(35-3)18(37-5)16(9-12)36-4;;;;;;;;/h6-10H,11H2,1-5H3,(H2,32,33,34)(H2,25,26,27,28,29);;;61H2/q;2+1;;;;;;/p-2
InChIKey	ZQGJCHHKJNSPMS-UHFFFAOYSA-L
Smiles	CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)([O-])[O-])C.O.O.O.O.O.O.[Na+].[Na+]
Isomeric SMILES	CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)([O-])[O-])C.O.O.O.O.O.O.[Na+].[Na+]
Molecular Weight	732.51
Reaxy-Rn	28316980
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=28316980&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot Number	Certificate Type	Date	Item
D23061549	Certificate of Analysis	Feb 15, 2023	F336802
D23061559	Certificate of Analysis	Feb 15, 2023	F336802
D23061548	Certificate of Analysis	Feb 15, 2023	F336802
D23061562	Certificate of Analysis	Feb 15, 2023	F336802
D23061563	Certificate of Analysis	Feb 15, 2023	F336802
D23061564	Certificate of Analysis	Feb 15, 2023	F336802
D23061561	Certificate of Analysis	Feb 15, 2023	F336802
D23061565	Certificate of Analysis	Feb 15, 2023	F336802
D23061560	Certificate of Analysis	Feb 15, 2023	F336802
D23061566	Certificate of Analysis	Feb 15, 2023	F336802

Chemical and Physical Properties

Molecular Weight	732.500 g/mol
XLogP3
Hydrogen Bond Donor Count	8
Hydrogen Bond Acceptor Count	21
Rotatable Bond Count	9
Exact Mass	732.176 Da
Monoisotopic Mass	732.176 Da
Topological Polar Surface Area	198.000 Å²
Heavy Atom Count	48
Formal Charge	0
Complexity	893.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	9

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