Basic Description

Synonyms	PLP \| P5P \| (4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate;hydrate \| Pyridoxal 5'-phosphate monohydrate \| Pyridoxal 5-phosphate monohydrate \| (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate hydrate(1:x) \| Tardoxa
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Vitamin B6 metabolite that acts as a coenzyme in transamination reactions by forming a Schiff-base linkage with lysine groups on aminotransferase. Also serves as a coenzyme in some decarboxylation and deamination reactions. Can modify lysyl and valyl resi
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Pyridoxal-5’-phosphate monohydrate is a vitamin B6 metabolite that can modify lysyl and valyl residues in proteins. It has the ability to inhibit purinergic receptors and intracellular influx of Ca2+. Pyridoxal-5’-phosphate monohydrate can modify peptides and suppress their precursor ionization efficiency. Research shows that pyridoxal-5'-phosphate-dependent enzymes can be inhibited by cycloserine. A vitamin B6 metabolite that can modify lysyl and valyl residues in proteins.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Pyridines and derivatives
    - Subclass Pyridine carboxaldehydes

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Pyridines and derivatives
Subclass	Pyridine carboxaldehydes
Intermediate Tree Nodes	Not available
Direct Parent	Pyridoxals and derivatives
Alternative Parents	Monoalkyl phosphates Methylpyridines Hydroxypyridines Aryl-aldehydes Vinylogous acids Heteroaromatic compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Pyridoxal - Aryl-aldehyde - Monoalkyl phosphate - Hydroxypyridine - Methylpyridine - Organic phosphoric acid derivative - Phosphoric acid ester - Alkyl phosphate - Vinylogous acid - Heteroaromatic compound - Azacycle - Organopnictogen compound - Aldehyde - Organic oxygen compound - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as pyridoxals and derivatives. These are compounds containing a pyridoxal moiety, which consists of a pyridine ring substituted at positions 2,3,4, and 5 by a methyl group, a hydroxyl group, a carbaldehyde group, and a hydroxymethyl group, respectively.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488183310
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488183310
IUPAC Name	(4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate;hydrate
INCHI	InChI=1S/C8H10NO6P.H2O/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14;/h2-3,11H,4H2,1H3,(H2,12,13,14);1H2
InChIKey	CEEQUQSGVRRXQI-UHFFFAOYSA-N
Smiles	CC1=NC=C(C(=C1O)C=O)COP(=O)(O)O.O
Isomeric SMILES	CC1=NC=C(C(=C1O)C=O)COP(=O)(O)O.O
WGK Germany	2
RTECS	UV1208000
Molecular Weight	265.16
Beilstein	234749
Reaxy-Rn	11305661
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=11305661&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

24 results found

Lot Number	Certificate Type	Date	Item
D2323271	Certificate of Analysis	Jan 06, 2025	P110916
D2323272	Certificate of Analysis	Jan 06, 2025	P110916
D2323273	Certificate of Analysis	Jan 06, 2025	P110916
D2323276	Certificate of Analysis	Jan 06, 2025	P110916
D2323277	Certificate of Analysis	Jan 06, 2025	P110916
D2323278	Certificate of Analysis	Jan 06, 2025	P110916
D2323270	Certificate of Analysis	Jan 06, 2025	P110916
D2323275	Certificate of Analysis	Jan 06, 2025	P110916
H2202471	Certificate of Analysis	May 07, 2024	P110916
H2202474	Certificate of Analysis	May 07, 2024	P110916
G2401135	Certificate of Analysis	Apr 01, 2024	P110916
G2401138	Certificate of Analysis	Apr 01, 2024	P110916
F2421477	Certificate of Analysis	Apr 01, 2024	P110916
C2526541	Certificate of Analysis	Apr 01, 2024	P110916
D2508035	Certificate of Analysis	Apr 01, 2024	P110916
K2108172	Certificate of Analysis	Aug 01, 2023	P110916
K2108173	Certificate of Analysis	Aug 01, 2023	P110916
K2108174	Certificate of Analysis	Aug 01, 2023	P110916
H2130336	Certificate of Analysis	Jun 06, 2023	P110916
H2130282	Certificate of Analysis	Jun 06, 2023	P110916
B1805021	Certificate of Analysis	Jun 05, 2023	P110916
B1805022	Certificate of Analysis	Jun 05, 2023	P110916
A2125163	Certificate of Analysis	Dec 06, 2022	P110916
H2202451	Certificate of Analysis	Jun 06, 2022	P110916

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Chemical and Physical Properties

Solubility	alkaline solutions; sparingly soluble in water
Sensitivity	Light & Air Sensitive.
Melt Point(°C)	143 °C
Molecular Weight	265.160 g/mol
XLogP3
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	4
Exact Mass	265.035 Da
Monoisotopic Mass	265.035 Da
Topological Polar Surface Area	118.000 Å²
Heavy Atom Count	17
Formal Charge	0
Complexity	292.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Liu Jianming, Zhang Han, Xu Yingying, Meng Hao, Zeng An-Ping. (2023) Turn air-captured CO2 with methanol into amino acid and pyruvate in an ATP/NAD(P)H-free chemoenzymatic system. Nature Communications, 14 (1): (1-12).
2. Junli Guo, Lingling Yang, Huijie Xu, Chenxi Zhao, Zhenqing Dai, Zhida Gao, Yanyan Song. (2019) Biomineralization-Driven Ion Gate in TiO2 Nanochannel Arrays for Cell H2S Sensing. ANALYTICAL CHEMISTRY, 91 (21): (13746–13751).
3. Chaoqiang Wu, Xin Zhang, Wei Liu, Chengyong Wang, Qianqian Jiang, Feifei Chen, Quanzhen Liu, Fei Cao, Gaowei Zheng, Alei Zhang, Kequan Chen. (2024) Biocatalytic Synthesis of Two Furan-Based Amino Compounds 2-Acetyl-4-aminofuran and 3-Acetylamino-5-(α-aminoethyl)-furan from Chitin Resources. ACS Sustainable Chemistry & Engineering, 12 (30): (11145-11154).
4. Wang Minyu, Chu Weihua. (2024) Dencichine attenuates the virulence of Fusobacterium nucleatum by targeting hydrogen sulfide-producing enzyme. INTERNATIONAL MICROBIOLOGY, (1-8).
5. Kuirong Feng, Lingxin Meng, Jingmei Xu, Pengyun Zhao, Na Li, Jinxuan Lei. (2024) Introduction of Bifunctionalized UIO-66-NH2 for Highly Conductive and Long-Term Stable Fluorene-Based Sulfonated Poly(aryl ether ketone sulfone) PEMs. ACS Applied Polymer Materials, 6 (17): (10916-10926).

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SKU	Size	Availability	Price
P110916-1g	1g	10	$17.90
P110916-5g	5g	8	$65.90
P110916-25g	25g	6	$184.90
P110916-100g	100g	2	$663.90
P110916-500g	500g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$2,985.90

Pyridoxal 5-Phosphate Monohydrate - 98%, high purity , CAS No.41468-25-1