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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab174248-100μg
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100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$79.90
|
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Ab174248-1mg
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1mg |
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
|
$357.90
|
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Ab174248-5mg
|
5mg |
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
|
$717.90
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Ab174248-10mg
|
10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$1,167.90
|
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Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Ponsegromab (anti-GDF15) - Primary antibody, specific to GDF15, >95%, high purity, Human IgG1 |
|---|---|
| Synonyms | GDF-15 | Macrophage inhibitory cytokine 1 | MIC-1 | NAG-1 | NRG-1 | NSAID-activated gene 1 protein | NSAID-regulated gene 1 protein | Placental bone morphogenetic protein | Placental TGF-beta | Prostate differentiation factor |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | GDF15 |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Product Description |
Ponsegromab (anti-GDF15) is a potent and selective humanized anti-GDF15 antibody inhibitor with anti-cachexia activity. Ponsegromab (anti-GDF15) binds to GDF15 and prevents the binding of GDF15 to GFRAL, thereby blocking GDF15/GFRAL-mediated signaling. Ponsegromab (anti-GDF15) can be used in the research of cancers. |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 26.2 kDa (Light Chain) & 51.6 kDa (Heavy Chain), under reducing conditions; 178.6 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 2368950-15-4 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Ponsegromab (anti-GDF15) (Ab174248) - ELISA
Immobilized huHis-GDF15 at 2 μg/mL can bind Ponsegromab (anti-GDF15) (Ab174248) with the EC₅₀ of 9.36 ng/mL.
Ponsegromab (anti-GDF15) (Ab174248) - SEC
The purity of Ponsegromab (anti-GDF15) (Ab174248) is more than 95% verified by HPLC.
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Nov 01, 2023 | Ab174248 | |
| Certificate of Analysis | Nov 01, 2023 | Ab174248 |
Starting at $66.90
Starting at $66.90
Starting at $89.90
Starting at $66.90