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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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N102401-5mg
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5mg |
2
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$69.90
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N102401-25mg
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25mg |
2
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$208.90
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N102401-100mg
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100mg |
1
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$467.90
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K + ionophore
| Synonyms | NIGERICIN, MONOSODIUM SALT | Q27276393 | NIGERICIN SODIUM SALT [MI] | Nigericin, sodium salt (1:1) | Nigericin (sodium salt) | Nigericin sodium salt | MLS001336038 | D82021 | Sodium;(2R)-2-[(3S,6R)-6-[[(2S,4R,5R,6R,7R,9R)-2-[(5S)-5-[(2R,3S,5R)-5-[(2S,3S,5 |
|---|---|
| Specifications & Purity | ≥98% |
| Biochemical and Physiological Mechanisms | Ionophore which disrupts membrane potential and stimulates ATPase activity in mitochondria. Polyether ionophore which disrupts membrane potential and stimulates ATPase activity in mitochondria. Ion selectivity is K+> Rb+≥ Cs+>> Na+.K + ionophore; exchange |
| Storage Temp | Store at -20°C,Argon charged |
| Shipped In |
Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available. |
| Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic oxygen compounds |
| Class | Organooxygen compounds |
| Subclass | Ethers |
| Intermediate Tree Nodes | Acetals |
| Direct Parent | Ketals |
| Alternative Parents | Oxanes Oxolanes Hemiacetals Carboxylic acid salts Oxacyclic compounds Monocarboxylic acids and derivatives Dialkyl ethers Carboxylic acids Primary alcohols Organic zwitterions Organic sodium salts Organic oxides Hydrocarbon derivatives Carbonyl compounds |
| Molecular Framework | Aliphatic heteropolycyclic compounds |
| Substituents | Ketal - Oxane - Oxolane - Carboxylic acid salt - Hemiacetal - Carboxylic acid derivative - Carboxylic acid - Dialkyl ether - Monocarboxylic acid or derivatives - Oxacycle - Organic alkali metal salt - Organoheterocyclic compound - Alcohol - Hydrocarbon derivative - Organic oxide - Primary alcohol - Organic zwitterion - Organic salt - Carbonyl group - Organic sodium salt - Aliphatic heteropolycyclic compound |
| Description | This compound belongs to the class of organic compounds known as ketals. These are acetals derived from ketones by replacement of the oxo group by two hydrocarbyloxy groups R2C(OR)2 ( R not Hydrogen ). This term, once abandoned, has been reinstated as a subclass of acetals. |
| External Descriptors | Not available |
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| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
| Pubchem Sid | 504768536 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504768536 |
| IUPAC Name | sodium;(2R)-2-[(2R,3S,6R)-6-[[(2S,4R,5R,6R,7R,9R)-2-[(2R,5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-7-methoxy-2,4,6-trimethyl-1,10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyloxan-2-yl]propanoate |
| INCHI | InChI=1S/C40H68O11.Na/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-31(47-35)34-22(2)15-24(4)39(44,20-41)50-34;/h21-35,41,44H,11-20H2,1-10H3,(H,42,43);/q;+1/p-1/t21-,22-,23-,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34-,35+,37-,38-,39-,40+;/m0./s1 |
| InChIKey | MOYOTUKECQMGHE-PDEFJWSRSA-M |
| Smiles | CC1CCC(OC1C(C)C(=O)[O-])CC2CC(C(C3(O2)C(CC(O3)(C)C4CCC(O4)(C)C5C(CC(O5)C6C(CC(C(O6)(CO)O)C)C)C)C)C)OC.[Na+] |
| Isomeric SMILES | C[C@H]1CC[C@@H](O[C@H]1[C@@H](C)C(=O)[O-])C[C@@H]2C[C@H]([C@H]([C@@]3(O2)[C@@H](C[C@@](O3)(C)[C@H]4CC[C@@](O4)(C)[C@H]5[C@H](C[C@@H](O5)[C@@H]6[C@H](C[C@H]([C@@](O6)(CO)O)C)C)C)C)C)OC.[Na+] |
| WGK Germany | 3 |
| RTECS | QT6840000 |
| PubChem CID | 16760591 |
| UN Number | 3462 |
| Molecular Weight | 746.94 |
| Beilstein | 3892398 |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Jun 10, 2025 | N102401 | |
| Certificate of Analysis | Jun 10, 2025 | N102401 | |
| Certificate of Analysis | Jun 10, 2025 | N102401 | |
| Certificate of Analysis | Jun 10, 2025 | N102401 | |
| Certificate of Analysis | May 20, 2024 | N102401 | |
| Certificate of Analysis | May 20, 2024 | N102401 | |
| Certificate of Analysis | Aug 08, 2023 | N102401 | |
| Certificate of Analysis | Aug 08, 2023 | N102401 | |
| Certificate of Analysis | Aug 08, 2023 | N102401 | |
| Certificate of Analysis | Aug 08, 2023 | N102401 | |
| Certificate of Analysis | Jun 08, 2022 | N102401 | |
| Certificate of Analysis | Jun 08, 2022 | N102401 | |
| Certificate of Analysis | Jun 08, 2022 | N102401 | |
| Certificate of Analysis | Jun 08, 2022 | N102401 | |
| Certificate of Analysis | Jun 08, 2022 | N102401 |
| Solubility | Soluble in chloroform, methanol or ethanol |
|---|---|
| Sensitivity | Moisture sensitive |
| Molecular Weight | 746.900 g/mol |
| XLogP3 | |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 11 |
| Rotatable Bond Count | 9 |
| Exact Mass | 746.458 Da |
| Monoisotopic Mass | 746.458 Da |
| Topological Polar Surface Area | 145.000 Ų |
| Heavy Atom Count | 52 |
| Formal Charge | 0 |
| Complexity | 1240.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 19 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 2 |
Starting at $334.90
| 1. Siyuan Li, Xianrong Yu, Linlin Zeng, Yuhan Xu, Xiaolan Zhao, Wei Tang, Xinrui Duan. (2022) A Sensitive Fluorescent Probe with Large Stokes Shift for Real-Time Tracking Lysosomal pH Changes in Live Cells. ChemistrySelect, 7 (42): (e202202620). |
| 2. Huangmei Zhou, Yu Zhao, Xihang Chen, Sanjun Zhang. (2022) Ultrafast spectroscopic studies of the pH responsive 9-acridinecarboxylic acid as a ratiometric and fluorescence lifetime pH indicator. MICROCHEMICAL JOURNAL, 176 (107240). |
| 3. Hongtian Chen, Piao Lv, Ziwei Liu, Wanjun Chen, Yuan Yao, Chixiang Liu, Qiong Cao, Huayou Zhou. (2021) Preliminary study on the function of TMEM50A and its correlation with the RH genes. TRANSFUSION MEDICINE, 31 (4): (277-285). |
| 4. Xu Shaomei, He Xu, Huang Yibing, Liu Xin, Zhao Lihe, Wang Xinghua, Sun Ying, Ma Pinyi, Song Daqian. (2020) Lysosome-targeted ratiometric fluorescent sensor for monitoring pH in living cells based on one-pot-synthesized carbon dots. MICROCHIMICA ACTA, 187 (8): (1-9). |
| 5. Shengrui Zhang, Xiaohui Ji, Jin Liu, Qin Wang, Lingxia Jin. (2020) One-step synthesis of yellow-emissive carbon dots with a large Stokes shift and their application in fluorimetric imaging of intracellular pH. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 227 (117677). |
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| 7. Yiling Mei, Xudong Chen, Si Shi, Wante Lin, Zhenfeng Cheng, Xiaoxi Fan, Wenqi Wu, Jibo Han, Weijian Huang, Bozhi Ye, Shanshan Dai. (2025) GI-Y2, a novel gasdermin D inhibitor, attenuates sepsis-induced myocardial dysfunction by inhibiting gasdermin D-mediated pyroptosis in macrophages. BRITISH JOURNAL OF PHARMACOLOGY, |