This is a demo store. No orders will be fulfilled.

Nigericin sodium salt - 98%, high purity , CAS No.28643-80-3

    Grade & Purity:
  • ≥98%
In stock
Item Number
N102401
Grouped product items
SKU Size
Availability
Price Qty
N102401-5mg
5mg
2
$69.90
N102401-25mg
25mg
2
$208.90
N102401-100mg
100mg
1
$467.90

K + ionophore

Basic Description

Synonyms NIGERICIN, MONOSODIUM SALT | Q27276393 | NIGERICIN SODIUM SALT [MI] | Nigericin, sodium salt (1:1) | Nigericin (sodium salt) | Nigericin sodium salt | MLS001336038 | D82021 | Sodium;(2R)-2-[(3S,6R)-6-[[(2S,4R,5R,6R,7R,9R)-2-[(5S)-5-[(2R,3S,5R)-5-[(2S,3S,5
Specifications & Purity ≥98%
Biochemical and Physiological Mechanisms Ionophore which disrupts membrane potential and stimulates ATPase activity in mitochondria. Polyether ionophore which disrupts membrane potential and stimulates ATPase activity in mitochondria. Ion selectivity is K+> Rb+≥ Cs+>> Na+.K + ionophore; exchange
Storage Temp Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organic oxygen compounds
Class Organooxygen compounds
Subclass Ethers
Intermediate Tree Nodes Acetals
Direct Parent Ketals
Alternative Parents Oxanes  Oxolanes  Hemiacetals  Carboxylic acid salts  Oxacyclic compounds  Monocarboxylic acids and derivatives  Dialkyl ethers  Carboxylic acids  Primary alcohols  Organic zwitterions  Organic sodium salts  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular Framework Aliphatic heteropolycyclic compounds
Substituents Ketal - Oxane - Oxolane - Carboxylic acid salt - Hemiacetal - Carboxylic acid derivative - Carboxylic acid - Dialkyl ether - Monocarboxylic acid or derivatives - Oxacycle - Organic alkali metal salt - Organoheterocyclic compound - Alcohol - Hydrocarbon derivative - Organic oxide - Primary alcohol - Organic zwitterion - Organic salt - Carbonyl group - Organic sodium salt - Aliphatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as ketals. These are acetals derived from ketones by replacement of the oxo group by two hydrocarbyloxy groups R2C(OR)2 ( R not Hydrogen ). This term, once abandoned, has been reinstated as a subclass of acetals.
External Descriptors Not available

Associated Targets(Human)

ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504768536
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504768536
IUPAC Name sodium;(2R)-2-[(2R,3S,6R)-6-[[(2S,4R,5R,6R,7R,9R)-2-[(2R,5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-7-methoxy-2,4,6-trimethyl-1,10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyloxan-2-yl]propanoate
INCHI InChI=1S/C40H68O11.Na/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-31(47-35)34-22(2)15-24(4)39(44,20-41)50-34;/h21-35,41,44H,11-20H2,1-10H3,(H,42,43);/q;+1/p-1/t21-,22-,23-,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34-,35+,37-,38-,39-,40+;/m0./s1
InChIKey MOYOTUKECQMGHE-PDEFJWSRSA-M
Smiles CC1CCC(OC1C(C)C(=O)[O-])CC2CC(C(C3(O2)C(CC(O3)(C)C4CCC(O4)(C)C5C(CC(O5)C6C(CC(C(O6)(CO)O)C)C)C)C)C)OC.[Na+]
Isomeric SMILES C[C@H]1CC[C@@H](O[C@H]1[C@@H](C)C(=O)[O-])C[C@@H]2C[C@H]([C@H]([C@@]3(O2)[C@@H](C[C@@](O3)(C)[C@H]4CC[C@@](O4)(C)[C@H]5[C@H](C[C@@H](O5)[C@@H]6[C@H](C[C@H]([C@@](O6)(CO)O)C)C)C)C)C)OC.[Na+]
WGK Germany 3
RTECS QT6840000
PubChem CID 16760591
UN Number 3462
Molecular Weight 746.94
Beilstein 3892398

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

15 results found

Lot Number Certificate Type Date Item
H2324179 Certificate of Analysis Jun 10, 2025 N102401
H2324204 Certificate of Analysis Jun 10, 2025 N102401
H2324239 Certificate of Analysis Jun 10, 2025 N102401
H2324181 Certificate of Analysis Jun 10, 2025 N102401
F2404268 Certificate of Analysis May 20, 2024 N102401
F2404367 Certificate of Analysis May 20, 2024 N102401
H2324346 Certificate of Analysis Aug 08, 2023 N102401
H2324201 Certificate of Analysis Aug 08, 2023 N102401
E2416007 Certificate of Analysis Aug 08, 2023 N102401
K2419118 Certificate of Analysis Aug 08, 2023 N102401
H2203647 Certificate of Analysis Jun 08, 2022 N102401
H2204024 Certificate of Analysis Jun 08, 2022 N102401
H2203646 Certificate of Analysis Jun 08, 2022 N102401
C23211076 Certificate of Analysis Jun 08, 2022 N102401
G2327050 Certificate of Analysis Jun 08, 2022 N102401

Show more⌵

Chemical and Physical Properties

Solubility Soluble in chloroform, methanol or ethanol
Sensitivity Moisture sensitive
Molecular Weight 746.900 g/mol
XLogP3
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 11
Rotatable Bond Count 9
Exact Mass 746.458 Da
Monoisotopic Mass 746.458 Da
Topological Polar Surface Area 145.000 Ų
Heavy Atom Count 52
Formal Charge 0
Complexity 1240.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 19
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 2

Citations of This Product

1. Siyuan Li, Xianrong Yu, Linlin Zeng, Yuhan Xu, Xiaolan Zhao, Wei Tang, Xinrui Duan.  (2022)  A Sensitive Fluorescent Probe with Large Stokes Shift for Real-Time Tracking Lysosomal pH Changes in Live Cells.  ChemistrySelect,  (42): (e202202620). 
2. Huangmei Zhou, Yu Zhao, Xihang Chen, Sanjun Zhang.  (2022)  Ultrafast spectroscopic studies of the pH responsive 9-acridinecarboxylic acid as a ratiometric and fluorescence lifetime pH indicator.  MICROCHEMICAL JOURNAL,  176  (107240). 
3. Hongtian Chen, Piao Lv, Ziwei Liu, Wanjun Chen, Yuan Yao, Chixiang Liu, Qiong Cao, Huayou Zhou.  (2021)  Preliminary study on the function of TMEM50A and its correlation with the RH genes.  TRANSFUSION MEDICINE,  31  (4): (277-285). 
4. Xu Shaomei, He Xu, Huang Yibing, Liu Xin, Zhao Lihe, Wang Xinghua, Sun Ying, Ma Pinyi, Song Daqian.  (2020)  Lysosome-targeted ratiometric fluorescent sensor for monitoring pH in living cells based on one-pot-synthesized carbon dots.  MICROCHIMICA ACTA,  187  (8): (1-9). 
5. Shengrui Zhang, Xiaohui Ji, Jin Liu, Qin Wang, Lingxia Jin.  (2020)  One-step synthesis of yellow-emissive carbon dots with a large Stokes shift and their application in fluorimetric imaging of intracellular pH.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  227  (117677). 
6. Ji Zhang, Jing Xie, Zhiqiang Niu, Long You, Yanan Liu, Rui Guo, Guigui Yang, Ziliang He, Ting Shen, Honggang Wang, Qi Yan, Weicheng Hu.  (2025)  Ginsenoside Rg2, a principal effective ingredient of Panax ginseng, attenuates DSS-induced ulcerative colitis through NF-κB/NLRP3 pathway.  Journal of Ginseng Research,     
7. Yiling Mei, Xudong Chen, Si Shi, Wante Lin, Zhenfeng Cheng, Xiaoxi Fan, Wenqi Wu, Jibo Han, Weijian Huang, Bozhi Ye, Shanshan Dai.  (2025)  GI-Y2, a novel gasdermin D inhibitor, attenuates sepsis-induced myocardial dysfunction by inhibiting gasdermin D-mediated pyroptosis in macrophages.  BRITISH JOURNAL OF PHARMACOLOGY,     

Solution Calculators

Reviews

Customer Reviews

Shall we send you a message when we have discounts available?

Remind me later

Thank you! Please check your email inbox to confirm.

Oops! Notifications are disabled.