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Nigericin sodium salt Ready Made Solution - 5mg/mL (DMSO:ethanol 1:1), high purity , CAS No.28643-80-3

6 Citations

COA

Grade & Purity:

5mg/mL (DMSO:ethanol 1:1)

Cas Number: 28643-80-3
Molecular Weight: 746.94
Beilstein Registry Number: 3892398
PubChem CID: 16760591

In stock

Item Number

N466621

Grouped product items
SKU	Size	Availability	Price	Qty
N466621-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$334.90

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Basic Description

Synonyms	NIGERICIN, MONOSODIUM SALT \| Q27276393 \| NIGERICIN SODIUM SALT [MI] \| Nigericin, sodium salt (1:1) \| Nigericin (sodium salt) \| Nigericin sodium salt \| MLS001336038 \| D82021 \| Sodium;(2R)-2-[(3S,6R)-6-[[(2S,4R,5R,6R,7R,9R)-2-[(5S)-5-[(2R,3S,5R)-5-[(2S,3S,5
Specifications & Purity	5mg/mL (DMSO:ethanol 1:1)
Biochemical and Physiological Mechanisms	Nigericin is a polyether ionophore which catalyzes the electroneutral exchange of alkali metal (K+) for H+(antiport). Nigericin transports monovalent cations across membranes with the following specificity: K+>Rb+>Cs+>>Na+and thus
Storage Temp	Store at 2-8°C
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic oxygen compounds
  - Class Organooxygen compounds
    - Subclass Ethers
      - Level5 Acetals
        Level6 Ketals

Kingdom	Organic compounds
Superclass	Organic oxygen compounds
Class	Organooxygen compounds
Subclass	Ethers
Intermediate Tree Nodes	Acetals
Direct Parent	Ketals
Alternative Parents	Oxanes Oxolanes Hemiacetals Carboxylic acid salts Oxacyclic compounds Monocarboxylic acids and derivatives Dialkyl ethers Carboxylic acids Primary alcohols Organic zwitterions Organic sodium salts Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aliphatic heteropolycyclic compounds
Substituents	Ketal - Oxane - Oxolane - Carboxylic acid salt - Hemiacetal - Carboxylic acid derivative - Carboxylic acid - Dialkyl ether - Monocarboxylic acid or derivatives - Oxacycle - Organic alkali metal salt - Organoheterocyclic compound - Alcohol - Hydrocarbon derivative - Organic oxide - Primary alcohol - Organic zwitterion - Organic salt - Carbonyl group - Organic sodium salt - Aliphatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as ketals. These are acetals derived from ketones by replacement of the oxo group by two hydrocarbyloxy groups R2C(OR)2 ( R not Hydrogen ). This term, once abandoned, has been reinstated as a subclass of acetals.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

ACHE Tclin Acetylcholinesterase (18204 Activities)

Discover Target: ACHE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	sodium;(2R)-2-[(2R,3S,6R)-6-[[(2S,4R,5R,6R,7R,9R)-2-[(2R,5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-7-methoxy-2,4,6-trimethyl-1,10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyloxan-2-yl]propanoate
INCHI	InChI=1S/C40H68O11.Na/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-31(47-35)34-22(2)15-24(4)39(44,20-41)50-34;/h21-35,41,44H,11-20H2,1-10H3,(H,42,43);/q;+1/p-1/t21-,22-,23-,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34-,35+,37-,38-,39-,40+;/m0./s1
InChIKey	MOYOTUKECQMGHE-PDEFJWSRSA-M
Smiles	CC1CCC(OC1C(C)C(=O)[O-])CC2CC(C(C3(O2)C(CC(O3)(C)C4CCC(O4)(C)C5C(CC(O5)C6C(CC(C(O6)(CO)O)C)C)C)C)C)OC.[Na+]
Isomeric SMILES	C[C@H]1CC[C@@H](O[C@H]1[C@@H](C)C(=O)[O-])C[C@@H]2C[C@H]([C@H]([C@@]3(O2)[C@@H](C[C@@](O3)(C)[C@H]4CC[C@@](O4)(C)[C@H]5[C@H](C[C@@H](O5)[C@@H]6[C@H](C[C@H]([C@@](O6)(CO)O)C)C)C)C)C)OC.[Na+]
WGK Germany	3
RTECS	QT6840000
PubChem CID	16760591
UN Number	3462
Molecular Weight	746.94
Beilstein	3892398

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Molecular Weight	746.900 g/mol
XLogP3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	9
Exact Mass	746.458 Da
Monoisotopic Mass	746.458 Da
Topological Polar Surface Area	145.000 Å²
Heavy Atom Count	52
Formal Charge	0
Complexity	1240.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	19
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Huangmei Zhou, Yu Zhao, Xihang Chen, Sanjun Zhang. (2022) Ultrafast spectroscopic studies of the pH responsive 9-acridinecarboxylic acid as a ratiometric and fluorescence lifetime pH indicator. MICROCHEMICAL JOURNAL, 176 (107240).
2. Hongtian Chen, Piao Lv, Ziwei Liu, Wanjun Chen, Yuan Yao, Chixiang Liu, Qiong Cao, Huayou Zhou. (2021) Preliminary study on the function of TMEM50A and its correlation with the RH genes. TRANSFUSION MEDICINE, 31 (4): (277-285).
3. Xu Shaomei, He Xu, Huang Yibing, Liu Xin, Zhao Lihe, Wang Xinghua, Sun Ying, Ma Pinyi, Song Daqian. (2020) Lysosome-targeted ratiometric fluorescent sensor for monitoring pH in living cells based on one-pot-synthesized carbon dots. MICROCHIMICA ACTA, 187 (8): (1-9).
4. Shengrui Zhang, Xiaohui Ji, Jin Liu, Qin Wang, Lingxia Jin. (2020) One-step synthesis of yellow-emissive carbon dots with a large Stokes shift and their application in fluorimetric imaging of intracellular pH. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 227 (117677).
5. Ji Zhang, Jing Xie, Zhiqiang Niu, Long You, Yanan Liu, Rui Guo, Guigui Yang, Ziliang He, Ting Shen, Honggang Wang, Qi Yan, Weicheng Hu. (2025) Ginsenoside Rg2, a principal effective ingredient of Panax ginseng, attenuates DSS-induced ulcerative colitis through NF-κB/NLRP3 pathway. Journal of Ginseng Research,
6. Yiling Mei, Xudong Chen, Si Shi, Wante Lin, Zhenfeng Cheng, Xiaoxi Fan, Wenqi Wu, Jibo Han, Weijian Huang, Bozhi Ye, Shanshan Dai. (2025) GI-Y2, a novel gasdermin D inhibitor, attenuates sepsis-induced myocardial dysfunction by inhibiting gasdermin D-mediated pyroptosis in macrophages. BRITISH JOURNAL OF PHARMACOLOGY,

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