Determine the necessary mass, volume, or concentration for preparing a solution.
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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab177932-100μg
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100μg |
10
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$109.90
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Ab177932-1mg
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1mg |
4
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$509.90
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Ab177932-5mg
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5mg |
1
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$1,259.90
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Ab177932-10mg
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10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$1,989.90
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Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Nadecnemab (anti-GFRA3) - Primary antibody, specific to GFRA3, >95%, high purity, Human IgG4SP |
|---|---|
| Synonyms | GDNF receptor alpha-3 | GDNFR-alpha-3 | GFR-alpha-3 |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | GFRA3 |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Product Description |
Nadecnemab (anti-GFRA3) is an IgG4κ antibody targeting to GFRA3, glial cell derived neurotrophic factor family receptor alpha 3. Nadecnemab (anti-GFRA3) can be used for research of osteoarthritis of the knee/pain[1]. |
| Isotype | Human IgG4SP |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 27.0 kDa (Light Chain) & 52.8 kDa (Heavy Chain), under reducing conditions; 181.1 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 2377679-19-9 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Nadecnemab (anti-GFRA3) (Ab177932) - ELISA
Immobilized Hu-GFRA3-His at 2 μg/mL can bind Nadecnemab (anti-GFRA3) (Ab177932) with the EC₅₀ of 11.80 ng/mL.
Nadecnemab (anti-GFRA3) (Ab177932) - SEC
The purity of Nadecnemab (anti-GFRA3) (Ab177932) is more than 95% verified by HPLC.
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Mar 08, 2024 | Ab177932 | |
| Certificate of Analysis | Mar 08, 2024 | Ab177932 | |
| Certificate of Analysis | Mar 08, 2024 | Ab177932 |