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N-Succinimidyl S-Acetylthioglycolate - >94.0%(GC), high purity , CAS No.76931-93-6

COA

Grade & Purity:

≥94%

Cas Number: 76931-93-6
Molecular Weight: 231.22
Beilstein Registry Number: 7815490
MDL number: MFCD00036891
PubChem CID: 127532

In stock

Item Number

N159207

Grouped product items
SKU	Size	Availability	Price
N159207-50mg	50mg	2	$73.90
N159207-100mg	100mg	2	$127.90
N159207-250mg	250mg	2	$288.90
N159207-500mg	500mg	1	$518.90
N159207-1g	1g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$933.90
N159207-5g	5g	1	$4,199.90

Primary amine-reactive protein modification thiolating reagent

View related series

Biochemical Assay Reagents (928) Non heterocyclic block (8163) Sulfur containing compounds (986)

Basic Description

Synonyms	SATA \| (2,5-dioxopyrrolidin-1-yl) 2-acetylsulfanylacetate \| S-Acetylthioglycolic Acid N-Succinimidyl Ester \| 4H-1-Benzopyran-2-carboxylic acid, 5,5'-((2-hydroxy-1,3-propanediyl)bis(oxy))bis(4-oxo- \| SATA \| N-Succinimidyl-S-acetylthioacetate; 2,5-Dioxopyrr
Specifications & Purity	≥94%
Biochemical and Physiological Mechanisms	Primary amine-reactive protein modification thiolating reagent. Adds protected sulfhydryls to targeted proteins. Induces stable recombinant TNF-α trimer formation by formation of disulfide bridges between reactive thiol groups on adjacent TNF-α molecules,
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Thiolating reagent for primary amines; thiol can be deprotected under mild conditions. Typically, couples initially to a molecule containing primary amine by amide bond buffered at pH 7.5. Deprotection may be accomplished with 0.05 M hydroxylamine at neutral pH. Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Pyrrolidines
    - Subclass Pyrrolidones

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Pyrrolidines
Subclass	Pyrrolidones
Intermediate Tree Nodes	Not available
Direct Parent	Pyrrolidine-2-ones
Alternative Parents	Dicarboximides Thioesters Lactams Carboxylic acid salts Carbothioic S-esters Sulfenyl compounds Monocarboxylic acids and derivatives Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic salts Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aliphatic heteromonocyclic compounds
Substituents	2-pyrrolidone - Dicarboximide - Carboxylic acid salt - Lactam - Thiocarboxylic acid ester - Carbothioic s-ester - Carboxylic acid derivative - Monocarboxylic acid or derivatives - Thiocarboxylic acid or derivatives - Sulfenyl compound - Azacycle - Organic oxide - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Carbonyl group - Organopnictogen compound - Hydrocarbon derivative - Organic nitrogen compound - Organic salt - Organic oxygen compound - Aliphatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as pyrrolidine-2-ones. These are pyrrolidines which bear a C=O group at position 2 of the pyrrolidine ring.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	(2,5-dioxopyrrolidin-1-yl) 2-acetylsulfanylacetate
INCHI	InChI=1S/C8H9NO5S/c1-5(10)15-4-8(13)14-9-6(11)2-3-7(9)12/h2-4H2,1H3
InChIKey	FLCQLSRLQIPNLM-UHFFFAOYSA-N
Smiles	CC(=O)SCC(=O)ON1C(=O)CCC1=O
Isomeric SMILES	CC(=O)SCC(=O)ON1C(=O)CCC1=O
WGK Germany	3
Molecular Weight	231.22
Beilstein	7815490
Reaxy-Rn	7815491
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7815491&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

16 results found

Lot Number	Certificate Type	Date	Item
D2107206	Certificate of Analysis	Jun 17, 2025	N159207
D2107201	Certificate of Analysis	Jan 09, 2025	N159207
H2414438	Certificate of Analysis	Aug 22, 2024	N159207
H2414518	Certificate of Analysis	Aug 22, 2024	N159207
H2414519	Certificate of Analysis	Aug 22, 2024	N159207
H2414437	Certificate of Analysis	Aug 22, 2024	N159207
H2414521	Certificate of Analysis	Aug 22, 2024	N159207
H2414522	Certificate of Analysis	Aug 22, 2024	N159207
H2414523	Certificate of Analysis	Aug 22, 2024	N159207
H2414520	Certificate of Analysis	Jul 30, 2024	N159207
B2302440	Certificate of Analysis	Jul 25, 2022	N159207
G2215550	Certificate of Analysis	Jul 25, 2022	N159207
G2215552	Certificate of Analysis	Jul 25, 2022	N159207
G2215551	Certificate of Analysis	Jul 25, 2022	N159207
G2215553	Certificate of Analysis	Jul 25, 2022	N159207
E2422105	Certificate of Analysis	Jul 25, 2022	N159207

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Chemical and Physical Properties

Solubility	solubility :acetonitrile: 50 mg/mL;DMF: soluble;
Sensitivity	Heat sensitive;Moisture sensitive
Melt Point(°C)	95 - 101°C
Molecular Weight	231.230 g/mol
XLogP3	-0.300
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	5
Exact Mass	231.02 Da
Monoisotopic Mass	231.02 Da
Topological Polar Surface Area	106.000 Å²
Heavy Atom Count	15
Formal Charge	0
Complexity	311.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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