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Mosunetuzumab (anti-CD20&CD3e) - Primary antibody, specific to MS4A1 & CD3E, Human IgG1, Antibody of CD20 (membrane-spanning 4-domains; subfamily A; member 1);Antibody of CD3e, Antibody of CD20 (membrane-spanning 4-domains; subfamily A; member 1);Antibody of CD3e

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab175605
Grouped product items
SKU Size
Availability
Price Qty
Ab175605-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$59.90
Ab175605-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$279.90
Ab175605-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$689.90
Ab175605-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,109.90

Purity≥90% (SDS-PAGE&SEC); Endotoxin Level≤1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Mosunetuzumab (anti-CD20&CD3e) - Primary antibody, specific to MS4A1 & CD3E, Human IgG1, Antibody of CD20 (membrane-spanning 4-domains; subfamily A; member 1);Antibody of CD3e
Synonyms APY antibody | ATOPY antibody | B lymphocyte antigen CD20 antibody | B Lymphocyte Cell Surface Antigen B1 antibody | B-lymphocyte antigen CD20 antibody | B-lymphocyte cell-surface antigen B1 antibody | B-lymphocyte surface antigen B1 antibody | B1 antibod
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥90%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity MS4A1 & CD3E
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type BINDING AGENT
Mechanism of action Antibody of CD20 (membrane-spanning 4-domains; subfamily A; member 1);Antibody of CD3e
Product Description

Mosunetuzumab (anti-CD20 & CD3e) is a full-length, fully humanized immunoglobulin G1 (IgG1) T-cell-dependent bispecific (TDB) antibody targeting CD20 (B cells) and CD3 (T cells). Mosunetuzumab (anti-CD20 & CD3e) redirects T cells to engage and eliminate malignant B cells and can be used for the research of relapsed or refractory (R/R) B-cell non-Hodgkin lymphomas (B-NHLs).
Purity
≥90% (SDS-PAGE&SEC)
Endotoxin Level
≤1.0EU/mg

Product Properties

Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 146.72 kDa
Purification Method Protein A purified
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS 1905409-39-3

Associated Targets(Human)

MS4A1 Tclin B-lymphocyte antigen CD20 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
CD3E Tclin T-cell surface glycoprotein CD3 epsilon chain (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
MS4A1 Tclin B-lymphocyte antigen CD20 (0 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CD3E Tclin T-cell surface glycoprotein CD3 epsilon chain (0 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Mosunetuzumab (anti-CD20&CD3e) (Ab175605) - Flow Cytometry
Flow Cytometry analysis of Raji cells labelling CD20&CD3e (red) with Mosunetuzumab (anti-CD20&CD3e) (Ab175605) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Mosunetuzumab (anti-CD20&CD3e) (Ab175605) - Flow Cytometry
Flow Cytometry analysis of Jurkat cells labelling CD20&CD3e (red) with Mosunetuzumab (anti-CD20&CD3e) (Ab175605) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Mosunetuzumab (anti-CD20&CD3e) (Ab175605) - SEC
The purity of Mosunetuzumab (anti-CD20&CD3e) (Ab175605) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Solution Calculators

Reviews

Customer Reviews

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