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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab175605-100μg
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100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$59.90
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Ab175605-1mg
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1mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$279.90
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Ab175605-5mg
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5mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$689.90
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Ab175605-10mg
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10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$1,109.90
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Purity≥90% (SDS-PAGE&SEC); Endotoxin Level≤1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Mosunetuzumab (anti-CD20&CD3e) - Primary antibody, specific to MS4A1 & CD3E, Human IgG1, Antibody of CD20 (membrane-spanning 4-domains; subfamily A; member 1);Antibody of CD3e |
|---|---|
| Synonyms | APY antibody | ATOPY antibody | B lymphocyte antigen CD20 antibody | B Lymphocyte Cell Surface Antigen B1 antibody | B-lymphocyte antigen CD20 antibody | B-lymphocyte cell-surface antigen B1 antibody | B-lymphocyte surface antigen B1 antibody | B1 antibod |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥90%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | MS4A1 & CD3E |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | BINDING AGENT |
| Mechanism of action | Antibody of CD20 (membrane-spanning 4-domains; subfamily A; member 1);Antibody of CD3e |
| Product Description |
Mosunetuzumab (anti-CD20 & CD3e) is a full-length, fully humanized immunoglobulin G1 (IgG1) T-cell-dependent bispecific (TDB) antibody targeting CD20 (B cells) and CD3 (T cells). Mosunetuzumab (anti-CD20 & CD3e) redirects T cells to engage and eliminate malignant B cells and can be used for the research of relapsed or refractory (R/R) B-cell non-Hodgkin lymphomas (B-NHLs). |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 146.72 kDa |
| Purification Method | Protein A purified |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle. |
| CAS | 1905409-39-3 |
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Mosunetuzumab (anti-CD20&CD3e) (Ab175605) - Flow Cytometry
Flow Cytometry analysis of Raji cells labelling CD20&CD3e (red) with Mosunetuzumab (anti-CD20&CD3e) (Ab175605) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Mosunetuzumab (anti-CD20&CD3e) (Ab175605) - Flow Cytometry
Flow Cytometry analysis of Jurkat cells labelling CD20&CD3e (red) with Mosunetuzumab (anti-CD20&CD3e) (Ab175605) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Mosunetuzumab (anti-CD20&CD3e) (Ab175605) - SEC
The purity of Mosunetuzumab (anti-CD20&CD3e) (Ab175605) is more than 95% verified by HPLC.