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Monalizumab (anti-NKG2A) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to NKG2A, >95%, high purity, Human IgG4SP, Antibody of killer cell lectin like receptor C1 (CD159a), Antibody of killer cell lectin like receptor C1 (CD159a)

COA COA
    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Baboon,Cynomolgus monkey,Human,Rhesus monkey
  • Isotype: Human IgG4SP
  • Conjugation: Unconjugated
In stock
Item Number
Ab170483
Grouped product items
SKU Size
Availability
 Price Qty
Ab170483-100μg
100μg
10
$109.90
Ab170483-1mg
1mg
4
$507.90
Ab170483-5mg
5mg
1
$1,377.90
Ab170483-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,187.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

View related series
Click to view target information: KLRC1
Accession#:P26715 (1) Cell Cycle (2830) Gene ID:3821 (1) killer cell lectin like receptor C1 (CD159a) Antibody (1) NKG2A (8)

Basic Description

Product Name Monalizumab (anti-NKG2A) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to NKG2A, >95%, high purity, Human IgG4SP, Antibody of killer cell lectin like receptor C1 (CD159a)
Synonyms CD159 antigen-like family member A | CD159a antigen | CD159a | C-lectin type II protein | killer cell lectin-like receptor subfamily C, member 1 | Klrc1 | MGC13374 | natural killer cell lectin | natural killer group protein 2 | NK cell receptor A | NKG2 |
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity NKG2A
Application ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action Antibody of killer cell lectin like receptor C1 (CD159a)
Product Description

Monalizumab is a first-in-class immune checkpoint inhibitor targeting Natural Killer Group 2A (NKG2A). Monalizumab, a humanized anti-NKG2A blocking mAb, increases IFN-γ production, thereby promoting NK cell effector functions. Monalizumab can be used for the research of head and neck squamous cell carcinoma (HNSCC).
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

Antibody Type Primary antibody
Clonality Recombinant
Isotype Human IgG4SP
Light Chain Type kappa
SDS-PAGE 26.4 kDa (Light Chain) & 52.1 kDa (Heavy Chain), under reducing conditions; 175.2 kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95%
Source CHO supernatant
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 1228763-95-8

Associated Targets(Human)

KLRC1 Tbio NKG2-A/NKG2-B type II integral membrane protein (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Monalizumab (anti-NKG2A) (Ab170483) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling NKG2A (red) with Monalizumab (anti-NKG2A) (Ab170483). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Monalizumab (anti-NKG2A) (Ab170483) - SEC
The purity of Monalizumab (anti-NKG2A) (Ab170483) is more than 95% verified by HPLC.

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0303666 Certificate of Analysis Mar 25, 2024 Ab170483
ZJ24F0303665 Certificate of Analysis Mar 25, 2024 Ab170483
ZJ24F0303664 Certificate of Analysis Mar 25, 2024 Ab170483

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