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MAdCAM1 Rat mAb - Primary antibody, specific to MAdCAM1, Rat IgG2a

    Application:
  • Animal Model
  • Blocking
  • Flow Cytometry
  • Functional Assay
  • IF/ICC
  • Neutralization
  • Host species: Rat
  • Reactive species: Mouse
  • Isotype: Rat IgG2a
  • Clone Number: MECA-367
  • Conjugation: Unconjugated
In stock
Item Number
Ab113964
Grouped product items
SKU Size
Availability
Price Qty
Ab113964-10μg
10μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$29.90
Ab113964-50μg
50μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$69.90
Ab113964-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$99.90
Ab113964-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$219.90

mAb (MECA-367); Rat anti Mouse MAdCAM1 Antibody; in vivo MAdCAM-1 neutralization, IF, ICC, Flow; Unconjugated

Basic Description

Product Name MAdCAM1 Rat mAb - Primary antibody, specific to MAdCAM1, Rat IgG2a
Synonyms hMAdCAM-1 | MACAM1 | MAdCAM1 | MAdCAM-1 | mucosal addressin cell adhesion molecule 1 | mucosal addressin cell adhesion molecule-1 | mucosal vascular addressin cell adhesion molecule 1 | Addressin mucosal antibody | hMAdCAM 1 antibody | hMAdCAM-1 antibody
Specifications & Purity Carrier Free, Azide Free, Validated, ≥95%(SDS-PAGE), See COA
Host species Rat
Specificity MAdCAM1
Immunogen Endothelial cells isolated from BALB/c mouse
Conjugation Unconjugated
Grade Azide Free, Carrier Free, Validated
Product Description

Rat anti Mouse MAdCAM1 Antibody, Monoclonal (MECA-367), could be used for in vivo MAdCAM-1 neutralization, IF, ICC, Flow and so on.
Application:
in vivo MAdCAM-1 neutralization: Use at an assay dependent concentration. 
ICC/IF: Use at an assay dependent concentration.
Flow: Use at an assay dependent concentration. 
Protein Function
Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.

Product Properties

Isotype Rat IgG2a
Light Chain Type kappa
SDS-PAGE 150 kDa
Purification Method Protein G purified
Shape Liquid
Concentration See COA
Storage Temp Store at 2-8°C,Do not freeze
Shipped In Wet ice
Stability And Storage Shipped at 4°C. Store at 4°C long term (12 months). Do not freeze. Upon receipt, it is recommended to aliquot.

Associated Targets(Human)

MADCAM1 Tbio Mucosal addressin cell adhesion molecule 1 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
COG1 Tbio Conserved oligomeric Golgi complex subunit 1 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
MADCAM1 Tbio Mucosal addressin cell adhesion molecule-1 (5 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

MAdCAM1 Rat mAb (Ab113964) - Flow Cytometry
Flow Cytometry analysis of unstimulated (left) or 20 ng/mL TNF-alpha (rp154759) stimulated bEND3​ cells (24 h) labelling MAdCAM1 (red) with MAdCAM1 Rat mAb (Ab113964) at 10.0 μg/mL for 1 hour at 4°C conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, Rat IgG (Biotin) (Ab180310). Black - Unlabelled control, cells without incubation with primary antibody.

Application

Application Dilution info
IF/ICC

Use at an assay dependent concentration.

Flow Cytometry

Use at an assay dependent concentration.

in vivo MAdCAM-1 neutralization

Use at an assay dependent concentration.

in vivo FasL blockade

Use at an assay dependent concentration.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0708487 Certificate of Analysis Jul 18, 2024 Ab113964
ZJ24F0708488 Certificate of Analysis Jul 18, 2024 Ab113964
ZJ24F0708489 Certificate of Analysis Jul 18, 2024 Ab113964

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