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Lusvertikimab (anti-CD127) - Primary antibody, specific to IL7R, Human IgG4SP

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human
  • Isotype: Human IgG4SP
  • Conjugation: Unconjugated
In stock
Item Number
Ab182935
Grouped product items
SKU Size
Availability
Price Qty
Ab182935-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$69.90
Ab182935-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$349.90
Ab182935-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$899.90
Ab182935-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,439.90

Purity≥95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Lusvertikimab (anti-CD127) - Primary antibody, specific to IL7R, Human IgG4SP
Synonyms CD 127 antibody | CD127 antibody | CD127 antigen antibody | CDw127 antibody | IL 7R alpha antibody | IL 7R antibody | IL-7 receptor subunit alpha antibody | IL-7R subunit alpha antibody | IL-7R-alpha antibody | IL-7RA antibody | IL7R antibody | IL7RA anti
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity IL7R
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Product Description

Lusvertikimab (anti-CD127) is a humanized IL7R monoclonal antibody. Lusvertikimab (anti-CD127) is not internalized by target cells and prevents IL7R heterodimerization and subsequent downstream signaling. Lusvertikimab (anti-CD127) has anti-leukemic efficacy and has the potential for B cell precursor acute lymphoblastic leukemia (BCP-ALL) research.
Purity
≥95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

Isotype Human IgG4SP
Light Chain Type kappa
SDS-PAGE 145.64 kDa
Purification Method Protein A purified
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 2375835-91-7

Associated Targets(Human)

IL7R Tbio Interleukin-7 receptor subunit alpha (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Images

Lusvertikimab (anti-CD127) (Ab182935) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD127 with Lusvertikimab (anti-CD127) (Ab182935) conjugated with biotin (right panel) compared with Human IgG (Biotin) (Ab180314) - Isotype Control (left panel) and detected with SA-PE (rp156150).

Lusvertikimab (anti-CD127) (Ab182935) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD127 (red) with Lusvertikimab (anti-CD127) (Ab182935) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, Human IgG (Biotin) (Ab180314). Black - Unlabelled control, cells without incubation with primary antibody.

Lusvertikimab (anti-CD127) (Ab182935) - Flow Cytometry
Flow Cytometry analysis of huTSLPR-IL7R-CHO-K cells at 1×105 cell/well can bind Lusvertikimab (anti-CD127) (Ab182935) with the EC ₅₀  of 0.1502 nM.

Lusvertikimab (anti-CD127) (Ab182935) - SEC
The purity of Lusvertikimab (anti-CD127) (Ab182935) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

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