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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab182935-100μg
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100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$69.90
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Ab182935-1mg
|
1mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$349.90
|
|
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Ab182935-5mg
|
5mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$899.90
|
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Ab182935-10mg
|
10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$1,439.90
|
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Purity≥95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Lusvertikimab (anti-CD127) - Primary antibody, specific to IL7R, Human IgG4SP |
|---|---|
| Synonyms | CD 127 antibody | CD127 antibody | CD127 antigen antibody | CDw127 antibody | IL 7R alpha antibody | IL 7R antibody | IL-7 receptor subunit alpha antibody | IL-7R subunit alpha antibody | IL-7R-alpha antibody | IL-7RA antibody | IL7R antibody | IL7RA anti |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | IL7R |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Product Description |
Lusvertikimab (anti-CD127) is a humanized IL7R monoclonal antibody. Lusvertikimab (anti-CD127) is not internalized by target cells and prevents IL7R heterodimerization and subsequent downstream signaling. Lusvertikimab (anti-CD127) has anti-leukemic efficacy and has the potential for B cell precursor acute lymphoblastic leukemia (BCP-ALL) research. |
| Isotype | Human IgG4SP |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 145.64 kDa |
| Purification Method | Protein A purified |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 2375835-91-7 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Lusvertikimab (anti-CD127) (Ab182935) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD127 with Lusvertikimab (anti-CD127) (Ab182935) conjugated with biotin (right panel) compared with Human IgG (Biotin) (Ab180314) - Isotype Control (left panel) and detected with SA-PE (rp156150).
Lusvertikimab (anti-CD127) (Ab182935) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD127 (red) with Lusvertikimab (anti-CD127) (Ab182935) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, Human IgG (Biotin) (Ab180314). Black - Unlabelled control, cells without incubation with primary antibody.
Lusvertikimab (anti-CD127) (Ab182935) - Flow Cytometry
Flow Cytometry analysis of huTSLPR-IL7R-CHO-K cells at 1×105 cell/well can bind Lusvertikimab (anti-CD127) (Ab182935) with the EC
₅₀
of 0.1502 nM.
Lusvertikimab (anti-CD127) (Ab182935) - SEC
The purity of Lusvertikimab (anti-CD127) (Ab182935) is more than 95% verified by HPLC.
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