Determine the necessary mass, volume, or concentration for preparing a solution.
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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab182813-100μg
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100μg |
10
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$69.90
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Ab182813-1mg
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1mg |
4
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$349.90
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Ab182813-5mg
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5mg |
1
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$899.90
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Ab182813-10mg
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10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$1,439.90
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Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Lirentelimab (anti-Siglec-8) - Primary antibody, specific to SIGLEC8, Human IgG1, INHIBITOR of Sialic acid-binding Ig-like lectin 8 inhibitor |
|---|---|
| Synonyms | CD329 antigen antibody | CDw329 antibody | SAF 2 antibody | SAF-2 antibody | SAF2 antibody | Sialic acid binding Ig like lectin 8 antibody | Sialic acid-binding Ig-like lectin 8 antibody | Sialoadhesin family member 2 antibody | SIGL8_HUMAN antibody | Sig |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | SIGLEC8 |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | INHIBITOR |
| Mechanism of action | INHIBITOR of Sialic acid-binding Ig-like lectin 8 inhibitor |
| Product Description |
Lirentelimab (anti-Siglec-8) is a humanized IgG1 monoclonal antibody that targets sialic acid-binding Ig-like lectin 8 (SIGLEC8). Lirentelimab (anti-Siglec-8) induces cell apoptosis of IL-5-activated eosinophils and inhibits IgE-mediated mast cell activation. Lirentelimab (anti-Siglec-8) can be used for the research of eosinophilic gastritis and duodenitis. |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 143.56 kDa |
| Purification Method | Protein A purified |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 2283348-97-8 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Lirentelimab (anti-Siglec-8) (Ab182813) - ELISA
Immobilized Human Siglec-8 His Tag at 2.0 μg/mL can bind Lirentelimab (anti-Siglec-8) (Ab182813) with the EC₅₀ of 3.69 ng/mL.
Lirentelimab (anti-Siglec-8) (Ab182813) - SEC
The purity of Lirentelimab (anti-Siglec-8) (Ab182813) is more than 95% verified by HPLC.
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Jun 21, 2024 | Ab182813 | |
| Certificate of Analysis | Jun 21, 2024 | Ab182813 | |
| Certificate of Analysis | Jun 21, 2024 | Ab182813 |