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Lirentelimab (anti-Siglec-8) - Primary antibody, specific to SIGLEC8, Human IgG1, INHIBITOR of Sialic acid-binding Ig-like lectin 8 inhibitor, INHIBITOR of Sialic acid-binding Ig-like lectin 8 inhibitor

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab182813
Grouped product items
SKU Size
Availability
Price Qty
Ab182813-100μg
100μg
10
$69.90
Ab182813-1mg
1mg
4
$349.90
Ab182813-5mg
5mg
1
$899.90
Ab182813-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,439.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Lirentelimab (anti-Siglec-8) - Primary antibody, specific to SIGLEC8, Human IgG1, INHIBITOR of Sialic acid-binding Ig-like lectin 8 inhibitor
Synonyms CD329 antigen antibody | CDw329 antibody | SAF 2 antibody | SAF-2 antibody | SAF2 antibody | Sialic acid binding Ig like lectin 8 antibody | Sialic acid-binding Ig-like lectin 8 antibody | Sialoadhesin family member 2 antibody | SIGL8_HUMAN antibody | Sig
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity SIGLEC8
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action INHIBITOR of Sialic acid-binding Ig-like lectin 8 inhibitor
Product Description

Lirentelimab (anti-Siglec-8) is a humanized IgG1 monoclonal antibody that targets sialic acid-binding Ig-like lectin 8 (SIGLEC8). Lirentelimab (anti-Siglec-8) induces cell apoptosis of IL-5-activated eosinophils and inhibits IgE-mediated mast cell activation. Lirentelimab (anti-Siglec-8) can be used for the research of eosinophilic gastritis and duodenitis.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 143.56 kDa
Purification Method Protein A purified
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 2283348-97-8

Associated Targets(Human)

SIGLEC8 Tbio Sialic acid-binding Ig-like lectin 8 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Lirentelimab (anti-Siglec-8) (Ab182813) - ELISA
Immobilized Human Siglec-8 His Tag at 2.0 μg/mL can bind Lirentelimab (anti-Siglec-8) (Ab182813) with the EC₅₀ of 3.69 ng/mL.

Lirentelimab (anti-Siglec-8) (Ab182813) - SEC
The purity of Lirentelimab (anti-Siglec-8) (Ab182813) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0607196 Certificate of Analysis Jun 21, 2024 Ab182813
ZJ24F0607195 Certificate of Analysis Jun 21, 2024 Ab182813
ZJ24F0607194 Certificate of Analysis Jun 21, 2024 Ab182813

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