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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab182826-100μg
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100μg |
10
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$89.90
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Ab182826-1mg
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1mg |
4
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$419.90
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Ab182826-5mg
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5mg |
1
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$1,089.90
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Ab182826-10mg
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10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$1,749.90
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Purity≥95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Elgemtumab (anti-ERBB3) - Primary antibody, specific to ERBB3, Human IgG1, INHIBITOR of Receptor tyrosine-protein kinase erbB-3 inhibitor |
|---|---|
| Synonyms | c erbB 3 antibody | c erbB3 antibody | Erb b2 receptor tyrosine kinase 3 antibody | ErbB 3 antibody | ERBB3 antibody | ERBB3 protein antibody | erbB3 S antibody | ERBB3_HUMAN antibody | Glial growth factor receptor antibody | HER 3 antibody | HER3 antibod |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | ERBB3 |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | INHIBITOR |
| Mechanism of action | INHIBITOR of Receptor tyrosine-protein kinase erbB-3 inhibitor |
| Product Description |
Elgemtumab (anti-ERBB3) is a fully human IgG monoclonal antibody. Elgemtumab (anti-ERBB3) can specifically bind to HER3, block ligand-dependent and independent HER3 signal transduction and cell proliferation, and has good anti-tumor potential. |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 26.4 kDa (Light Chain) & 50.5 kDa (Heavy Chain), under reducing conditions; 205.6 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 1512559-37-3 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Elgemtumab (anti-ERBB3) (Ab182826) - Flow Cytometry
Flow Cytometry analysis of A431 cells labelling ERBB3 (red) with Elgemtumab (anti-ERBB3) (Ab182826). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Elgemtumab (anti-ERBB3) (Ab182826) - ELISA
Immobilized Recombinant Human ErbB3/HER3 protein (rp170123) at 1.0 μg/mL can bind Elgemtumab (anti-ERBB3) (Ab182826) with the EC50 of 31.89 ng/mL.
Elgemtumab (anti-ERBB3) (Ab182826) - SEC
The purity of Elgemtumab (anti-ERBB3) (Ab182826) is more than 95% verified by HPLC.
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | May 21, 2024 | Ab182826 | |
| Certificate of Analysis | May 21, 2024 | Ab182826 | |
| Certificate of Analysis | May 21, 2024 | Ab182826 |
Starting at $29.90
Starting at $109.90