Skip to the beginning of the images gallery

L-DON - 98%, high purity , CAS No.157-03-9

COA

Grade & Purity:

≥98%

Cas Number: 157-03-9
Molecular Weight: 171.15
PubChem CID: 9087

In stock

Item Number

L287002

Grouped product items
SKU	Size	Availability	Price
L287002-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$65.90
L287002-5mg	5mg	3	$229.90
L287002-10mg	10mg	3	$399.90

Glutaminase inhibitor; also inhibits other glutamine-using enzymes and transporters

View related series

Amino Acid/Protein Metabolism (1836) Anti-infection (2803) Antibiotic (1629) Bacterial (3013) Glutaminase (27) Influenza Virus (253) Metabolic Enzyme/Protease (4860) Virus (1811)

Basic Description

Synonyms	L-6-Diazo-5-oxonorleucine \| 6-Diazo-5-oxo-L-nor-Leucine \| 6-diazo-5-oxo-L-norleucine
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Glutaminase inhibitor (Ki= 6 μM). Also inhibits other glutamine-using enzymes, amino acid transporters and transglutaminases. Displays antitumor effects and reduces tumor weight in a range of mouse xenograft models.
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic acids and derivatives
  - Class Carboxylic acids and derivatives
    - Subclass Amino acids, peptides, and analogues
      - Level5 Amino acids and derivatives
        Level6 Alpha amino acids and derivatives
        Level7 Alpha amino acids
        Level8 L-alpha-amino acids

Kingdom	Organic compounds
Superclass	Organic acids and derivatives
Class	Carboxylic acids and derivatives
Subclass	Amino acids, peptides, and analogues
Intermediate Tree Nodes	Amino acids and derivatives - Alpha amino acids and derivatives - Alpha amino acids
Direct Parent	L-alpha-amino acids
Alternative Parents	Medium-chain fatty acids Amino fatty acids Gamma-amino ketones Alpha-diazo ketones Diazo compounds Amino acids Monocarboxylic acids and derivatives Carboxylic acids Organic zwitterions Organic salts Organic oxides Monoalkylamines Hydrocarbon derivatives
Molecular Framework	Aliphatic acyclic compounds
Substituents	L-alpha-amino acid - Medium-chain fatty acid - Amino fatty acid - Gamma-aminoketone - Alpha-diazo ketone - Fatty acid - Fatty acyl - Amino acid - Diazo compound - Ketone - Carboxylic acid - Monocarboxylic acid or derivatives - Organic nitrogen compound - Organic oxygen compound - Primary amine - Organooxygen compound - Organonitrogen compound - Amine - Primary aliphatic amine - Organic zwitterion - Organic salt - Carbonyl group - Organic oxide - Hydrocarbon derivative - Aliphatic acyclic compound
Description	This compound belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	(2S)-2-amino-6-diazo-5-oxohexanoic acid
INCHI	InChI=1S/C6H9N3O3/c7-5(6(11)12)2-1-4(10)3-9-8/h3,5H,1-2,7H2,(H,11,12)/t5-/m0/s1
InChIKey	YCWQAMGASJSUIP-YFKPBYRVSA-N
Smiles	C(CC(=O)C=[N+]=[N-])C(C(=O)O)N
Isomeric SMILES	C(CC(=O)C=[N+]=[N-])[C@@H](C(=O)O)N
Molecular Weight	171.15
Reaxy-Rn	1725816
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1725816&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number	Certificate Type	Date	Item
C2422250	Certificate of Analysis	Mar 11, 2024	L287002
C2422251	Certificate of Analysis	Mar 11, 2024	L287002
L2312371	Certificate of Analysis	Dec 06, 2023	L287002
L2312372	Certificate of Analysis	Dec 06, 2023	L287002

Chemical and Physical Properties

Solubility	Solvent:water, Max Conc. mg/mL: 8.56, Max Conc. mM: 50
Sensitivity	Moisture sensitive
Molecular Weight	171.150 g/mol
XLogP3	-3.500
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Exact Mass	171.064 Da
Monoisotopic Mass	171.064 Da
Topological Polar Surface Area	82.400 Å²
Heavy Atom Count	12
Formal Charge	0
Complexity	232.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	1
The total count of all stereochemical bonds	1
Covalently-Bonded Unit Count	1

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions, always use the batch-specific molecular weight of the product found on the vial label and the Certificate of Analysis (available online).

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator enables you to quickly determine the volume of a reagent needed to reconstitute your vial. Just enter the mass of the reagent and the target concentration, and the calculator will do the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration