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L-DON - 10mM in Water, high purity , CAS No.157-03-9

COA

Grade & Purity:

10mM in Water

Cas Number: 157-03-9
Molecular Weight: 171.15
PubChem CID: 9087

In stock

Item Number

L421882

Grouped product items
SKU	Size	Availability	Price	Qty
L421882-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$241.90

Glutaminase inhibitor; also inhibits other glutamine-using enzymes and transporters

View related series

Amino Acid/Protein Metabolism (1836) Antibiotic (1629) Bacterial (3013) Compound libraries (12325) Virus (1811)

Basic Description

Synonyms	6-diazo-5-oxo-L-norleucine \| 157-03-9 \| diazooxonorleucine \| L-DON \| L-Norleucine, 6-diazo-5-oxo- \| 6-Diazo-5-oxo-L-nor-Leucine \| L-6-Diazo-5-oxonorleucine \| NSC-7365 \| 03J0H273KZ \| DON (pharmaceutical) \| MFCD00037218 \| L-Norleucine,6-diazo-5-oxo- \| NSC 7365 \| BRN 1725815 \| Norleuci
Specifications & Purity	10mM in Water
Biochemical and Physiological Mechanisms	Glutaminase inhibitor (Ki= 6 μM). Also inhibits other glutamine-using enzymes, amino acid transporters and transglutaminases. Displays antitumor effects and reduces tumor weight in a range of mouse xenograft models.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic acids and derivatives
  - Class Carboxylic acids and derivatives
    - Subclass Amino acids, peptides, and analogues
      - Level5 Amino acids and derivatives
        Level6 Alpha amino acids and derivatives
        Level7 Alpha amino acids
        Level8 L-alpha-amino acids

Kingdom	Organic compounds
Superclass	Organic acids and derivatives
Class	Carboxylic acids and derivatives
Subclass	Amino acids, peptides, and analogues
Intermediate Tree Nodes	Amino acids and derivatives - Alpha amino acids and derivatives - Alpha amino acids
Direct Parent	L-alpha-amino acids
Alternative Parents	Medium-chain fatty acids Amino fatty acids Gamma-amino ketones Alpha-diazo ketones Diazo compounds Amino acids Monocarboxylic acids and derivatives Carboxylic acids Organic zwitterions Organic salts Organic oxides Monoalkylamines Hydrocarbon derivatives
Molecular Framework	Aliphatic acyclic compounds
Substituents	L-alpha-amino acid - Medium-chain fatty acid - Amino fatty acid - Gamma-aminoketone - Alpha-diazo ketone - Fatty acid - Fatty acyl - Amino acid - Diazo compound - Ketone - Carboxylic acid - Monocarboxylic acid or derivatives - Organic nitrogen compound - Organic oxygen compound - Primary amine - Organooxygen compound - Organonitrogen compound - Amine - Primary aliphatic amine - Organic zwitterion - Organic salt - Carbonyl group - Organic oxide - Hydrocarbon derivative - Aliphatic acyclic compound
Description	This compound belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	(2S)-2-amino-6-diazo-5-oxohexanoic acid
INCHI	InChI=1S/C6H9N3O3/c7-5(6(11)12)2-1-4(10)3-9-8/h3,5H,1-2,7H2,(H,11,12)/t5-/m0/s1
InChIKey	YCWQAMGASJSUIP-YFKPBYRVSA-N
Smiles	C(CC(=O)C=[N+]=[N-])C(C(=O)O)N
Isomeric SMILES	C(CC(=O)C=[N+]=[N-])[C@@H](C(=O)O)N
Molecular Weight	171.15
Reaxy-Rn	1725816
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1725816&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Molecular Weight	171.150 g/mol
XLogP3	-3.500
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Exact Mass	171.064 Da
Monoisotopic Mass	171.064 Da
Topological Polar Surface Area	82.400 Å²
Heavy Atom Count	12
Formal Charge	0
Complexity	232.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	1
The total count of all stereochemical bonds	1
Covalently-Bonded Unit Count	1

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