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Itolizumab (anti-CD6) - Primary antibody, specific to CD6, >95%, high purity, Human IgG1, INHIBITOR of T-cell differentiation antigen CD6 inhibitor, INHIBITOR of T-cell differentiation antigen CD6 inhibitor

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human,Mouse,Rat
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab176610
Grouped product items
SKU Size
Availability
Price Qty
Ab176610-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$79.90
Ab176610-1mg
1mg
5
$389.90
Ab176610-5mg
5mg
1
$1,009.90
Ab176610-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,619.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Itolizumab (anti-CD6) - Primary antibody, specific to CD6, >95%, high purity, Human IgG1, INHIBITOR of T-cell differentiation antigen CD6 inhibitor
Synonyms CD_antigen=CD6 antibody | CD6 antibody | CD6 antigen Tp120 antibody | CD6 molecule antibody | CD6_HUMAN antibody | FLJ44171 antibody | OX52 antibody | T cell differentiation antigen CD6 antibody | T-cell differentiation antigen CD6 antibody | T12 antibody
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity CD6
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action INHIBITOR of T-cell differentiation antigen CD6 inhibitor
Product Description

Itolizumab (anti-CD6) is a humanized recombinant anti-CD6 monoclonal antibody (MAb) targeting the extracellular SRCR distal domain 1 of CD6. Itolizumab (anti-CD6) reduces T-cell proliferation and inhibits the production of pro-inflammatory cytokines, such as INF-γ, TNFα and IL-6. Itolizumab (anti-CD6) can be used in the research of psoriasis, rheumatoid arthritis (RA), COVID-19.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 27.8 kDa (Light Chain) & 50.6 kDa (Heavy Chain), under reducing conditions; 175.2 kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95%
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 1116433-11-4

Associated Targets(Human)

CD6 Tbio T-cell differentiation antigen CD6 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Itolizumab (anti-CD6) (Ab176610) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD6 with Itolizumab (anti-CD6) (Ab176610) conjugated with biotin (right panel) compared with Human IgG (Ab170213) conjugated with biotin - Isotype Control (left panel) and detected with SA-PE (rp156150).

Itolizumab (anti-CD6) (Ab176610) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD6 (red) with Itolizumab (anti-CD6) (Ab176610) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, human IgG (Ab170213) conjugated with biotin. Black - Unlabelled control, cells without incubation with primary antibody.

Itolizumab (anti-CD6) (Ab176610) - Flow Cytometry
Flow Cytometry analysis of MOLT-4 cells labelling CD6 (red) with Itolizumab (anti-CD6) (Ab176610). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Itolizumab (anti-CD6) (Ab176610) - Flow Cytometry
Flow Cytometry analysis of Jurkat cells labelling CD6 (red) with Itolizumab (anti-CD6) (Ab176610). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Itolizumab (anti-CD6) (Ab176610) - SEC
The purity of Itolizumab (anti-CD6) (Ab176610) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
ZJ23F1202085 Certificate of Analysis Dec 20, 2023 Ab176610
ZJ23F1202084 Certificate of Analysis Dec 20, 2023 Ab176610

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