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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab176610-100μg
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100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$79.90
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Ab176610-1mg
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1mg |
5
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$389.90
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Ab176610-5mg
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5mg |
1
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$1,009.90
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Ab176610-10mg
|
10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$1,619.90
|
|
Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Itolizumab (anti-CD6) - Primary antibody, specific to CD6, >95%, high purity, Human IgG1, INHIBITOR of T-cell differentiation antigen CD6 inhibitor |
|---|---|
| Synonyms | CD_antigen=CD6 antibody | CD6 antibody | CD6 antigen Tp120 antibody | CD6 molecule antibody | CD6_HUMAN antibody | FLJ44171 antibody | OX52 antibody | T cell differentiation antigen CD6 antibody | T-cell differentiation antigen CD6 antibody | T12 antibody |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | CD6 |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | INHIBITOR |
| Mechanism of action | INHIBITOR of T-cell differentiation antigen CD6 inhibitor |
| Product Description |
Itolizumab (anti-CD6) is a humanized recombinant anti-CD6 monoclonal antibody (MAb) targeting the extracellular SRCR distal domain 1 of CD6. Itolizumab (anti-CD6) reduces T-cell proliferation and inhibits the production of pro-inflammatory cytokines, such as INF-γ, TNFα and IL-6. Itolizumab (anti-CD6) can be used in the research of psoriasis, rheumatoid arthritis (RA), COVID-19. |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 27.8 kDa (Light Chain) & 50.6 kDa (Heavy Chain), under reducing conditions; 175.2 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 1116433-11-4 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Itolizumab (anti-CD6) (Ab176610) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD6 with Itolizumab (anti-CD6) (Ab176610) conjugated with biotin (right panel) compared with Human IgG (Ab170213) conjugated with biotin - Isotype Control (left panel) and detected with SA-PE (rp156150).
Itolizumab (anti-CD6) (Ab176610) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD6 (red) with Itolizumab (anti-CD6) (Ab176610) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, human IgG (Ab170213) conjugated with biotin. Black - Unlabelled control, cells without incubation with primary antibody.
Itolizumab (anti-CD6) (Ab176610) - Flow Cytometry
Flow Cytometry analysis of MOLT-4 cells labelling CD6 (red) with Itolizumab (anti-CD6) (Ab176610). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Itolizumab (anti-CD6) (Ab176610) - Flow Cytometry
Flow Cytometry analysis of Jurkat cells labelling CD6 (red) with Itolizumab (anti-CD6) (Ab176610). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Itolizumab (anti-CD6) (Ab176610) - SEC
The purity of Itolizumab (anti-CD6) (Ab176610) is more than 95% verified by HPLC.
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Dec 20, 2023 | Ab176610 | |
| Certificate of Analysis | Dec 20, 2023 | Ab176610 |
Starting at $29.90