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Itepekimab (anti-IL-33) - Primary antibody, specific to IL33, >95%, high purity, Human IgG4SP, INHIBITOR of Interleukin-33 inhibitor, INHIBITOR of Interleukin-33 inhibitor

COA COA
    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human
  • Isotype: Human IgG4SP
  • Conjugation: Unconjugated
In stock
Item Number
Ab177904
Grouped product items
SKU Size
Availability
 Price Qty
Ab177904-100μg
100μg
10
$69.90
Ab177904-1mg
1mg
4
$339.90
Ab177904-5mg
5mg
1
$859.90
Ab177904-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,369.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

View related series
Click to view target information: IL33
Accession#:O95760 (6) Gene ID:90865 (6) IL33 (6)

Basic Description

Product Name Itepekimab (anti-IL-33) - Primary antibody, specific to IL33, >95%, high purity, Human IgG4SP, INHIBITOR of Interleukin-33 inhibitor
Synonyms IL-1F11 | IL-33 | Interleukin-1 family member 11 | NF-HEV | Nuclear factor from high endothelial venules
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity IL33
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action INHIBITOR of Interleukin-33 inhibitor
Product Description

Itepekimab (anti-IL-33) is a monoclonal antibody of IL-33. Itepekimab (anti-IL-33) reduces airway inflammation and related tissue damage in previous clinical studies. Itepekimab (anti-IL-33) has potential application in asthma, chronic obstructive pulmonary disease (COPD) and atopic dermatitis (AD).

Product Properties

Isotype Human IgG4SP
Light Chain Type kappa
SDS-PAGE 26.2 kDa (Light Chain) & 51.8 kDa (Heavy Chain), under reducing conditions; 195.4 kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95%
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 2226742-52-3

Associated Targets(Human)

IL33 Tbio Interleukin-33 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Itepekimab (anti-IL-33) (Ab177904) - ELISA
Immobilized Recombinant Human IL-33 Protein (rp169652) at 2.0 μg/mL can bind Itepekimab (anti-IL-33) (Ab177904) with the EC₅₀ of 45.69 ng/mL.

Itepekimab (anti-IL-33) (Ab177904) - SEC
The purity of Itepekimab (anti-IL-33) (Ab177904) is more than 95% verified by HPLC.

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0404223 Certificate of Analysis Apr 08, 2024 Ab177904
ZJ24F0404222 Certificate of Analysis Apr 08, 2024 Ab177904
ZJ24F0404221 Certificate of Analysis Apr 08, 2024 Ab177904

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