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Apoptosis
Apoptosis
IR 783 - >98.0%(HPLC), high purity , CAS No.115970-66-6

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IR 783 - >98.0%(HPLC), high purity , CAS No.115970-66-6

8 Citations

COA

Grade & Purity:

≥98%(HPLC)

Cas Number: 115970-66-6
Molecular Weight: 749.35
MDL number: MFCD03093208
PubChem CID: 53438012
PubChem SID: 504771254

In stock

Item Number

I157644

Grouped product items
SKU	Size	Availability	Price
I157644-50mg	50mg	3	$18.90
I157644-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$51.90
I157644-1g	1g	3	$149.90
I157644-5g	5g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$519.90

View related series

Apoptosis (4276) azole (525) Five-Membered Heterocyclic Compounds (2064)

Basic Description

Synonyms	DTXSID00701181 \| MFCD03093208 \| FT-0696354 \| Sodium 4-{2-[2-(2-chloro-3-{2-[3,3-dimethyl-1-(4-sulfonatobutyl)-1,3-dihydro-2H-indol-2-ylidene]ethylidene}cyclohex-1-en-1-yl)ethenyl]-3,3-dimethyl-3H-indol-1-ium-1-yl}butane-1-sulfonate \| SY055929 \| F9995-0848
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	IR-783 (ADS 780WS) is a near-infrared (NIR) heptamethine cyanine fluorescent probe. IR-783 significantly inhibits tumour growth and induces apoptosis in MDA-MB-231 xenograft model. IR-783 can be used to study breast cancer
Storage Temp	Store at 2-8°C
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	IR-783 is a near-infrared (NIR) dye with an extinction coefficient of 157000 M−1cm−1 and quantum yield of 0.11. Its excitation wavelength is in the range of 768-784 nm in saline. Application： IR-783 can be used as a starting material in the synthesis of IR-808 dye for biological applications. It can also be used in the formation of NIR fluorescent human serum albumin nanoparticles for the detection of a tumor. It finds potential usage as a contrasting agent for the multimodal in vivo imaging.

Names and Identifiers

Pubchem Sid	504771254
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504771254
IUPAC Name	sodium;4-[2-[2-[2-chloro-3-[2-[3,3-dimethyl-1-(4-sulfonatobutyl)indol-1-ium-2-yl]ethenyl]cyclohex-2-en-1-ylidene]ethylidene]-3,3-dimethylindol-1-yl]butane-1-sulfonate
INCHI	InChI=1S/C38H47ClN2O6S2.Na/c1-37(2)30-16-5-7-18-32(30)40(24-9-11-26-48(42,43)44)34(37)22-20-28-14-13-15-29(36(28)39)21-23-35-38(3,4)31-17-6-8-19-33(31)41(35)25-10-12-27-49(45,46)47;/h5-8,16-23H,9-15,24-27H2,1-4H3,(H-,42,43,44,45,46,47);/q;+1/p-1
InChIKey	QQIQAVJARACLHE-UHFFFAOYSA-M
Smiles	CC1(C2=CC=CC=C2[N+](=C1C=CC3=C(C(=CC=C4C(C5=CC=CC=C5N4CCCCS(=O)(=O)[O-])(C)C)CCC3)Cl)CCCCS(=O)(=O)[O-])C.[Na+]
Isomeric SMILES	CC1(C2=CC=CC=C2[N+](=C1C=CC3=C(C(=CC=C4C(C5=CC=CC=C5N4CCCCS(=O)(=O)[O-])(C)C)CCC3)Cl)CCCCS(=O)(=O)[O-])C.[Na+]
Molecular Weight	749.35
Reaxy-Rn	14503446
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=14503446&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

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Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot Number	Certificate Type	Date	Item
E2324248	Certificate of Analysis	Mar 04, 2025	I157644
C2512521	Certificate of Analysis	Jan 15, 2025	I157644
C2512563	Certificate of Analysis	Jan 15, 2025	I157644
C2512564	Certificate of Analysis	Jan 15, 2025	I157644
F2506079	Certificate of Analysis	Jan 15, 2025	I157644
C2517760	Certificate of Analysis	Jan 15, 2025	I157644
L2108568	Certificate of Analysis	Sep 19, 2023	I157644
L2108569	Certificate of Analysis	Sep 19, 2023	I157644
L2109146	Certificate of Analysis	Sep 19, 2023	I157644
H1909186	Certificate of Analysis	Mar 07, 2023	I157644

Chemical and Physical Properties

Sensitivity	Moisture sensitive
Melt Point(°C)	212 °C

Documents & Articles

Fluorescent Probes - Absorption and Fluorescence

Categories: Technical articles

Tags:

Fluorescence Fuorescent Probe Fluorescent dyes

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Mingzhi Zhu, Pei Wang, Biaoqi Chen, Linrong Shi, Ruimin Long, Shibin Wang, Yuangang Liu. (2024) Active-oxygenating hollow Prussian blue nanosystems loaded with biomacromolecules for photodynamic/photothermal therapy of cancer and alleviating hypoxic tumors. MATERIALS & DESIGN, 237 (112618).
2. Xiaoxia Wu, Dinghu Zhang, Ting Pan, Jianwei Li, Yujiao Xie, Chenguang Zhang, Chunshu Pan, Zhewei Zhang, Jie Lin, Aiguo Wu, Guoliang Shao. (2023) Stimuli-Responsive Codelivery System Self-Assembled from in Situ Dynamic Covalent Reaction of Macrocyclic Disulfides for Cancer Magnetic Resonance Imaging and Chemotherapy. ACS Applied Materials & Interfaces, 15 (38): (44773–44785).
3. Wei Zhang, Yibao Fan, Jinze Zhang, Dan Shi, Jiahui Yuan, Milad Ashrafizadeh, Wei Li, Man Hu, A.M. Abd El-Aty, Ahmet Hacimuftuoglu, Michael Linnebacher, Yongxian Cheng, Weiguang Li, Shuo Fang, Peng Gong, Xianbin Zhang. (2023) Cell membrane-camouflaged bufalin targets NOD2 and overcomes multidrug resistance in pancreatic cancer. DRUG RESISTANCE UPDATES, 71 (101005).
4. Jiaqi Zhou, Hao Li, Hui Li, Jiayi Ding, Zhong Du, Jiabao Xiong, Hongyang Yao, Xueliang Zhang, Nuernisha Alifu, Biao Dong. (2025) Constructing J-aggregates of Cyanine Dye for NIR-II in vivo Dynamic Vascular Imaging and Long-Term Targeting of Tumors. Materials Today Bio, (101693).
5. Man Zhang, Ke Li, Junhao Kou, Guozhi Lu, Ling Qiu, Chunzhao Yang, Yongchun Liu, Qi Xue, Peng Yang. (2024) Functionalized Amyloid-Like Protein Nanofilm-Mediated Synergistic Disulfidptosis and Photodynamic Therapy for Preventing Postoperative Recurrence of Colorectal Cancer. Small Science, (2400323).
6. Wenrun Li, Li Shen, Shiyan Fu, Yong Li, Feng Huang, Qi Li, Qinyang Lin, Hongjia Liu, Qiuchi Wang, Liyi Chen, Huanhuan Tan, Juan Li, Yazhen Zhao, Yonghong Ran, Yuhui Hao. (2024) Mitochondrial-Targeting Mesoporous Polydopamine Nanoparticles for Reducing Kidney Injury Caused by Depleted Uranium. Advanced Healthcare Materials, (2403015).
7. Fan Yibao, Zhang Wei, Iqbal Zoya, Li Xinxin, Lin Zhiyin, Wu Zhuolin, Li Qianyou, Dong Hongxia, Zhang Xianbin, Gong Peng, Liu Peng. (2024) Rod-shaped mesoporous silica nanoparticles reduce bufalin cardiotoxicity and inhibit colon cancer by blocking lipophagy. Lipids in Health and Disease, 23 (1): (1-12).
8. Wu Xiao-Xia, Zhang Ding-Hu, Ding Yi-Nan, Cao Fei, Li Yang, Yao Jun-Lie, Miao Xin-Yu, He Lu-Lu, Luo Jun, Li Jian-Wei, Lin Jie, Wu Ai-Guo, Zheng Jia-Ping. (2025) Self-assembled co-delivery system of gold nanoparticles and paclitaxel based on in-situ dynamic covalent chemistry for synergistic chemo-photothermal therapy. RARE METALS, 44 (1): (417-429).

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