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Gevokizumab (anti-IL-1b) - Primary antibody, specific to IL1B, >95%, high purity, Human IgG2, NEGATIVE ALLOSTERIC MODULATOR of Interleukin-1 beta negative allosteric modulator, NEGATIVE ALLOSTERIC MODULATOR of Interleukin-1 beta negative allosteric modulator

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human,Rhesus monkey
  • Isotype: Human IgG2
  • Conjugation: Unconjugated
In stock
Item Number
Ab175856
Grouped product items
SKU Size
Availability
Price Qty
Ab175856-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$49.90
Ab175856-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$207.90
Ab175856-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$537.90
Ab175856-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$837.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG2; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Gevokizumab (anti-IL-1b) - Primary antibody, specific to IL1B, >95%, high purity, Human IgG2, NEGATIVE ALLOSTERIC MODULATOR of Interleukin-1 beta negative allosteric modulator
Synonyms Catabolin antibody | H1 antibody | IFN beta inducing factor antibody | IL 1 antibody | IL 1 beta antibody | IL-1 beta antibody | IL1 antibody | IL1 BETA antibody | IL1B antibody | IL1B_HUMAN antibody | IL1F2 antibody | Interleukin 1 beta antibody | Interl
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity IL1B
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type NEGATIVE ALLOSTERIC MODULATOR
Mechanism of action NEGATIVE ALLOSTERIC MODULATOR of Interleukin-1 beta negative allosteric modulator
Product Description

Gevokizumab (anti-IL-1b) is a potent anti-IL-1β antibody, negatively modulates IL-1β signaling through an allosteric mechanism. Gevokizumab (anti-IL-1b) selectively decreases the binding affinity of IL-1β for the IL-1 receptor type I (IL-1RI) signaling receptor instead of IL-1 counter-regulatory decoy receptor (IL-1 receptor type II).
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

Isotype Human IgG2
Light Chain Type kappa
SDS-PAGE 26.8 kDa (Light Chain) & 51.4 kDa (Heavy Chain), under reducing conditions; 170.1 kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95%
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 1129435-60-4

Associated Targets(Human)

IL1B Tclin Interleukin-1 beta (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Gevokizumab (anti-IL-1b) (Ab175856) - ELISA
Immobilized Recombinant Human IL-1 beta Protein (rp147346) at 1.0 μg/mL can bind Gevokizumab (anti-IL-1b) (Ab175856) with the EC₅₀ of 56.74 ng/mL.

Gevokizumab (anti-IL-1b) (Ab175856) - SEC
The purity of Gevokizumab (anti-IL-1b) (Ab175856) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
ZJ23F1001515 Certificate of Analysis Nov 02, 2023 Ab175856
ZJ23F1001524 Certificate of Analysis Nov 02, 2023 Ab175856

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