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Geniposide - analytical standard，≥98%, high purity , CAS No.24512-63-8

14 Citations COA COA
In stock
Item Number
G101668
Grouped product items
SKU Size
Availability
 Price Qty
G101668-20mg
20mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$97.90
G101668-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$375.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Iridoid glycoside. Glukagon-like peptide-1 receptor agonist.

View related series
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Basic Description

Synonyms DTXSID101318419 | Cyclopenta(c)pyran-4-carboxylic acid, 1-(beta-D-glucopyranosyloxy)-1,4a,5,7a-tetrahydro-7-(hydroxymethyl)-, methyl ester, (1S,4aS,7aS)- | (1S)-1alpha-(beta-D-Glucopyranosyloxy)-7-(hydroxymethyl)-1,4aalpha,5,7aalpha-tetrahydrocyclopenta[c
Specifications & Purity analytical standard, ≥98%
Biochemical and Physiological Mechanisms Geniposide is an iridoid glycoside with a variety of biological activities including neuroprotective, anti-diabetic, antiproliferative, and antioxidative activity. Geniposide has been shown to regulate Nrf2 translocation and upregulate downstream antioxid
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade analytical standard
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Lipids and lipid-like molecules
Class Prenol lipids
Subclass Terpene glycosides
Intermediate Tree Nodes Not available
Direct Parent Iridoid O-glycosides
Alternative Parents Hexoses  O-glycosyl compounds  Bicyclic monoterpenoids  Iridoids and derivatives  Oxanes  Methyl esters  Enoate esters  Vinylogous esters  Secondary alcohols  Oxacyclic compounds  Polyols  Monocarboxylic acids and derivatives  Acetals  Organic oxides  Primary alcohols  Hydrocarbon derivatives  Carbonyl compounds  
Molecular Framework Aliphatic heteropolycyclic compounds
Substituents Iridoid o-glycoside - Hexose monosaccharide - Glycosyl compound - Iridoid-skeleton - O-glycosyl compound - Bicyclic monoterpenoid - Monoterpenoid - Monosaccharide - Oxane - Vinylogous ester - Alpha,beta-unsaturated carboxylic ester - Enoate ester - Methyl ester - Carboxylic acid ester - Secondary alcohol - Acetal - Organoheterocyclic compound - Monocarboxylic acid or derivatives - Oxacycle - Carboxylic acid derivative - Polyol - Organooxygen compound - Alcohol - Hydrocarbon derivative - Organic oxide - Carbonyl group - Primary alcohol - Organic oxygen compound - Aliphatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as iridoid o-glycosides. These are iridoid monoterpenes containing a glycosyl (usually a pyranosyl) moiety linked to the iridoid skeleton.
External Descriptors Iridoids

Associated Targets(Human)

XDH Tclin Xanthine dehydrogenase (1038 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PTPN2 Tchem T-cell protein-tyrosine phosphatase (1317 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PTPN11 Tchem Protein-tyrosine phosphatase 2C (2297 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Raji (5516 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
dsDNA (365 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
quadruplex DNA (2700 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HK-2 (249 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Ptpn1 Protein-tyrosine phosphatase 1B (270 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
pol Human immunodeficiency virus type 1 integrase (9041 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mus musculus (284745 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hepatitis C virus (23859 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Enterovirus A71 (1246 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RAW264.7 (28094 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Drosophila (190 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name methyl (1S,4aS,7aS)-7-(hydroxymethyl)-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylate
INCHI InChI=1S/C17H24O10/c1-24-15(23)9-6-25-16(11-7(4-18)2-3-8(9)11)27-17-14(22)13(21)12(20)10(5-19)26-17/h2,6,8,10-14,16-22H,3-5H2,1H3/t8-,10-,11-,12-,13+,14-,16+,17+/m1/s1
InChIKey IBFYXTRXDNAPMM-BVTMAQQCSA-N
Smiles COC(=O)C1=COC(C2C1CC=C2CO)OC3C(C(C(C(O3)CO)O)O)O
Isomeric SMILES COC(=O)C1=CO[C@H]([C@H]2[C@@H]1CC=C2CO)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O
WGK Germany 3
Molecular Weight 388.37
Reaxy-Rn 33425786
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=33425786&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number Certificate Type Date Item
F2221292 Certificate of Analysis Mar 21, 2024 G101668
K2111707 Certificate of Analysis Aug 03, 2023 G101668
K2111708 Certificate of Analysis Aug 03, 2023 G101668
I1918024 Certificate of Analysis Apr 11, 2023 G101668
C1722092 Certificate of Analysis Sep 21, 2022 G101668

Chemical and Physical Properties

Specific Rotation[α] 15° (C=1,EtOH)
Melt Point(°C) 162°C
Molecular Weight 388.400 g/mol
XLogP3 -2.300
Hydrogen Bond Donor Count 5
Hydrogen Bond Acceptor Count 10
Rotatable Bond Count 6
Exact Mass 388.137 Da
Monoisotopic Mass 388.137 Da
Topological Polar Surface Area 155.000 Ų
Heavy Atom Count 27
Formal Charge 0
Complexity 617.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 8
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

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Citations of This Product

How to Cite Aladdin Scientific Products?
1. Yuxin Gan, Chenyu Wang, Chenfeng Xu, Pingping Zhang, Shutong Chen, Lei Tang, Junbing Zhang, Huahao Zhang, Shenhua Jiang.  (2023)  Simultaneous extraction of crocin and geniposide from gardenia fruits (Gardenia jasminoides Ellis) by probe-type ultrasound-assisted natural deep eutectic solvents and their inhibition effects on low density lipoprotein oxidation.  ULTRASONICS SONOCHEMISTRY,  101  (106658). 
2. Xiaoju Zhuge, Xiaosheng Jin, Tingting Ji, Rongzhou Li, Liwei Xue, Weilai Yu, Zijiao Quan, Haibin Tong, Fang Xu.  (2023)  Geniposide ameliorates dextran sulfate sodium-induced ulcerative colitis via KEAP1-Nrf2 signaling pathway.  JOURNAL OF ETHNOPHARMACOLOGY,  314  (116626). 
3. Ling Li, Ling Zhou, Gongshuai Song, Danli Wang, Gongnian Xiao, Fuping Zheng, Jinyan Gong.  (2023)  High efficiency biosynthesis of gardenia blue and red pigment by lactic acid bacteria: A great potential for natural color pigments.  FOOD CHEMISTRY,  417  (135868). 
4. Jiaxin Li, Hengju Ge, Yang Xu, Jiahong Xie, Fujie Yan, Wei Chen.  (2022)  Geniposide Alleviates Oxidative Damage in Hepatocytes through Regulating miR-27b-3p/Nrf2 Axis.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  70  (37): (11544–11553). 
5. Sitong Lu, Zhaoyu Zhang, Youling Liang, Qingkun Zhong, Guangfa Li, Zhang Hu.  (2022)  Iridoid Glycosides from Phlomis Medicinalis Diels: Optimized Extraction and Hemostasis Evaluation.  CHEMISTRY & BIODIVERSITY,  19  (5): (e202100936). 
6. Tang Liqin, Liu Haocheng, Wen Jing, Xu Yujuan, Tian Wenni, Li Lu, Yu Yuanshan, Lin Xian, Fu Manqin.  (2021)  Study on ultrahigh-pressure extraction technology on properties of yellow extract from gardenia fruit.  JOURNAL OF FOOD COMPOSITION AND ANALYSIS,  104  (104186). 
7. Zilong Chen, Hongdong Liu, Jie Chen, Weifeng Zhu, Yong Liu, Jianxin Min, Xiaotian Chen, Bin Li, Xin Yang.  (2021)  Separation and enrichment of sibiskoside from Sibiraea angustat with magnetic surface dummy template molecularly imprinted polymers.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,  1178  (122767). 
8. Dong-Xing Liu, Di Zhang, Wei-Min Hu, Yan-Fang Chang, Xiao-Hui Wang, Lin Li.  (2021)  Geniposide protection against Aβ1-42 toxicity correlates with mTOR inhibition and enhancement of autophagy.  Journal of Integrative Neuroscience,  20  (1): (67-75). 
9. Ma Chongyang, Wang Xueqian, Xu Tian, Zhang Shuang, Liu Shuling, Zhai Changming, Wang Zisong, Mu Jie, Li Changxiang, Cheng Fafeng, Wang Qingguo.  (2020)  An Integrative Pharmacology-Based Analysis of Refined Qingkailing Injection Against Cerebral Ischemic Stroke: A Novel Combination of Baicalin, Geniposide, Cholic Acid, and Hyodeoxycholic Acid.  Frontiers in Pharmacology,  11  (519). 
10. Sen Yang, Ge Kuang, Rong Jiang, Shengwang Wu, Tao Zeng, Yuanyuan Wang, Fangzhi Xu, Lingyi Xiong, Xia Gong, Jingyuan Wan.  (2019)  Geniposide protected hepatocytes from acetaminophen hepatotoxicity by down-regulating CYP 2E1 expression and inhibiting TLR 4/NF-κB signaling pathway.  INTERNATIONAL IMMUNOPHARMACOLOGY,  74  (105625). 
11. Guixin Wu, Min Wen, Lin Sun, Huitao Li, Yubei Liu, Rui Li, Feihua Wu, Rong Yang, Yining Lin.  (2018)  Mechanistic insights into geniposide regulation of bile salt export pump (BSEP) expression.  RSC Advances,  8  (65): (37117-37128). 
12. Wenhao Xu, Jingbo Yu, Wen Feng, Weike Su.  (2016)  Selective Extraction of Gardenia Yellow and Geniposide from Gardenia jasminoides by Mechanochemistry.  MOLECULES,  21  (5): (540). 
13. Han Yan-lu, Yan Teng-teng, Li Hua-xin, Chen Sha-sha, Zhang Zhen-zhen, Wang Meng-yao, Chen Mei-jie, Chen Yuan-li, Yang Xiao-xiao, Wei Ling-ling, Duan Ya-jun, Zhang Shuang.  (2024)  Geniposide alleviates heart failure with preserved ejection fraction in mice by regulating cardiac oxidative stress via MMP2/SIRT1/GSK3β pathway.  ACTA PHARMACOLOGICA SINICA,    (1-12). 
14. Yu Zhang, Fang-Mei Liu, Cun-Yu Li, Xue-Jiao Leng, Yun-Feng Zheng, Guo-Ping Peng.  (2025)  Qingkailing injection induces pseudo-allergic reactions via the MRGPRX2 pathway.  American Journal of Translational Research,  17  (3): (2178). 

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