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Chonglou Saponin VII - 98%, high purity , CAS No.68124-04-9

1 Citations

COA

Grade & Purity:

≥98%

Cas Number: 68124-04-9
Molecular Weight: 1031.18
MDL number: MFCD20260362
PubChem CID: 176233
PubChem SID: 504757685

In stock

Item Number

C304363

Grouped product items
SKU	Size	Availability	Price
C304363-1mg	1mg	2	$31.90
C304363-5mg	5mg	2	$132.90
C304363-25mg	25mg	2	$598.90
C304363-100mg	100mg	2	$2,154.90

View related series

Akt (180) Apoptosis (4276) Autophagy (1917) Bcl-2 Family (144) Caspase (131) Cell Cycle/DNA Damage (2602) DNA Damage (697) Epigenetics (1496) Histone Modification (1379) Intrinsic Pathway (690) MAPK/ERK Pathway (546) Membrane Transporter (607) Membrane Transporter/Ion Channel (1822) P-glycoprotein (65) p38 MAPK (136) PARP (124) PI3K/Akt/mTOR (765)

Basic Description

Synonyms	Paris VII \| DTXSID101318576 \| HY-N3584 \| CCG-270613 \| beta-D-Glucopyranoside, (3beta,25R)-17-hydroxyspirost-5-en-3-yl O-6-deoxy-alpha-L-mannopyranosyl-(1-2)-O-(O-6-deoxy-alpha-L-mannopyranosyl-(1-4)-6-deoxy-alpha-L-mannopyranosyl-(1-4))- \| s9156 \| AKOS032
Specifications & Purity	≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Chonglou Saponin VII, a kind of steroidal saponins from Chonglou (Rhizoma Paridis Chonglou), inhibits EMT and reduces the invasion of ovarian cancer cells via the GSK-3β/β-catenin signaling pathway. Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Lipids and lipid-like molecules
  - Class Steroids and steroid derivatives
    - Subclass Steroidal glycosides

Kingdom	Organic compounds
Superclass	Lipids and lipid-like molecules
Class	Steroids and steroid derivatives
Subclass	Steroidal glycosides
Intermediate Tree Nodes	Not available
Direct Parent	Steroidal saponins
Alternative Parents	Triterpenoids Spirostanes and derivatives Oligosaccharides 17-hydroxysteroids Delta-5-steroids O-glycosyl compounds Ketals Oxanes Tetrahydrofurans Tertiary alcohols Secondary alcohols Cyclic alcohols and derivatives Oxacyclic compounds Polyols Primary alcohols Hydrocarbon derivatives
Molecular Framework	Aliphatic heteropolycyclic compounds
Substituents	Steroidal saponin - Triterpenoid - Spirostane skeleton - Oligosaccharide - Hydroxysteroid - 17-hydroxysteroid - Delta-5-steroid - Glycosyl compound - O-glycosyl compound - Ketal - Oxane - Cyclic alcohol - Tetrahydrofuran - Tertiary alcohol - Secondary alcohol - Acetal - Organoheterocyclic compound - Oxacycle - Polyol - Organooxygen compound - Organic oxygen compound - Primary alcohol - Hydrocarbon derivative - Alcohol - Aliphatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as steroidal saponins. These are saponins in which the aglycone moiety is a steroid. The steroidal aglycone is usually a spirostane, furostane, spirosolane, solanidane, or curcubitacin derivative.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

Pubchem Sid	504757685
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504757685
IUPAC Name	(2S,3R,4R,5R,6S)-2-[(2S,3R,4S,5R,6S)-4,5-dihydroxy-6-[(2R,3S,4S,5R,6R)-4-hydroxy-2-(hydroxymethyl)-6-[(1R,2S,4S,5'R,6R,7S,8S,9S,12S,13R,16S)-8-hydroxy-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-16-yl]oxy-5-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl]oxy-2-methyloxan-3-yl]oxy-6-methyloxane-3,4,5-triol
INCHI	InChI=1S/C51H82O21/c1-20-10-15-50(63-19-20)24(5)51(62)31(72-50)17-29-27-9-8-25-16-26(11-13-48(25,6)28(27)12-14-49(29,51)7)67-47-43(71-45-38(59)35(56)33(54)22(3)65-45)40(61)42(30(18-52)68-47)70-46-39(60)36(57)41(23(4)66-46)69-44-37(58)34(55)32(53)21(2)64-44/h8,20-24,26-47,52-62H,9-19H2,1-7H3/t20-,21+,22+,23+,24-,26+,27-,28+,29+,30-,31+,32+,33+,34-,35-,36+,37-,38-,39-,40+,41+,42-,43-,44+,45+,46+,47-,48+,49+,50-,51-/m1/s1
InChIKey	FBFJAXUYHGSVFN-IYUYFXHASA-N
Smiles	CC1CCC2(C(C3(C(O2)CC4C3(CCC5C4CC=C6C5(CCC(C6)OC7C(C(C(C(O7)CO)OC8C(C(C(C(O8)C)OC9C(C(C(C(O9)C)O)O)O)O)O)O)OC2C(C(C(C(O2)C)O)O)O)C)C)O)C)OC1
Isomeric SMILES	C[C@@H]1CC[C@@]2([C@H]([C@]3([C@@H](O2)C[C@@H]4[C@@]3(CC[C@H]5[C@H]4CC=C6[C@@]5(CC[C@@H](C6)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O[C@H]8[C@@H]([C@@H]([C@H]([C@@H](O8)C)O[C@H]9[C@@H]([C@@H]([C@H]([C@@H](O9)C)O)O)O)O)O)O)O[C@H]2[C@@H]([C@@H]([C@H]([C@@H](O2)C)O)O)O)C)C)O)C)OC1
PubChem CID	176233
Molecular Weight	1031.18

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number	Certificate Type	Date	Item
I2103109	Certificate of Analysis	Jun 13, 2024	C304363
I2103110	Certificate of Analysis	Jun 13, 2024	C304363
I2103194	Certificate of Analysis	Jun 13, 2024	C304363
I2103195	Certificate of Analysis	Jun 13, 2024	C304363

Chemical and Physical Properties

Sensitivity	Light sensitive
Molecular Weight	1031.200 g/mol
XLogP3	-1.000
Hydrogen Bond Donor Count	11
Hydrogen Bond Acceptor Count	21
Rotatable Bond Count	9
Exact Mass	1030.53 Da
Monoisotopic Mass	1030.53 Da
Topological Polar Surface Area	315.000 Å²
Heavy Atom Count	72
Formal Charge	0
Complexity	1950.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	31
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Citations of This Product

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