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Fremanezumab (anti-CALCA) - Primary antibody, specific to CALCA, >95% (SDS-PAGE&SEC), high purity, Human IgG2SA, ANTAGONIST of Calcitonin gene-related peptide antagonist, ANTAGONIST of Calcitonin gene-related peptide antagonist

COA COA
    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human
  • Isotype: Human IgG2SA
  • Conjugation: Unconjugated
In stock
Item Number
Ab175765
Grouped product items
SKU Size
Availability
 Price Qty
Ab175765-100μg
100μg
10
$49.90
Ab175765-1mg
1mg
4
$239.90
Ab175765-5mg
5mg
1
$599.90
Ab175765-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$949.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<0.01EU/μg; Human IgG2SA; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

View related series
Click to view target information: CALCA Click to view target information: CALCA
Accession#:P06881 (2) CALCA (8) Class B GPCR (170) Gene ID:796 (8)

Basic Description

Product Name Fremanezumab (anti-CALCA) - Primary antibody, specific to CALCA, >95% (SDS-PAGE&SEC), high purity, Human IgG2SA, ANTAGONIST of Calcitonin gene-related peptide antagonist
Synonyms Calcitonin/calcitonin related polypeptide alpha antibody | Alpha type CGRP antibody | Beta type CGRP antibody | CALC1 antibody | CALC2 antibody | CALCA antibody | CALCB antibody | Calcitonin 1 antibody | Calcitonin 2 antibody | Calcitonin gene related pep
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity CALCA
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Recombinant, Validated
Action Type ANTAGONIST
Mechanism of action ANTAGONIST of Calcitonin gene-related peptide antagonist
Product Description

Fremanezumab (anti-CALCA) is a humanized IgG2a monoclonal antibody that selectively and potently binds to calcitonin gene-related peptide (CGRP). CGRP is a 37-amino acid neuropeptide involved in central and peripheral pathophysiological events of migraine. Fremanezumab (anti-CALCA) has the potential for chronic migraine research.
Purity>95% (SDS-PAGE&SEC)
Endotoxin Level< 0.01EU/μg

Product Properties

Isotype Human IgG2SA
Light Chain Type kappa
SDS-PAGE 27.2 kDa (Light Chain) & 49.8 kDa (Heavy Chain), under reducing conditions; 160.5 kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95% (SDS-PAGE&SEC)
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 1655501-53-3

Associated Targets(Human)

CALCA Tclin Calcitonin gene-related peptide 1 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
CALCA Tbio Calcitonin (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
CALCA Tclin Calcitonin gene-related peptide 1 (214 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Fremanezumab (anti-CALCA) (Ab175765) - ELISA
Immobilized hu-CALCA-KLH at 2 μg/mL can bind Fremanezumab (anti-CALCA) (Ab175765) with the EC₅₀ of 6.76 ng/mL.

Fremanezumab (anti-CALCA) (Ab175765) - SEC
The purity of Fremanezumab (anti-CALCA) (Ab175765) is more than 95% verified by HPLC.

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0404235 Certificate of Analysis Apr 08, 2024 Ab175765
ZJ24F0404234 Certificate of Analysis Apr 08, 2024 Ab175765
ZJ24F0404233 Certificate of Analysis Apr 08, 2024 Ab175765

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