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Tag Click Chemistry
Articles by tag "Click Chemistry"
- Azide-Alkyne Click Chemistry Classic Click Chemistry uses copper, Cu(I), to catalyze the 1,3-dipolar cycloaddition of an alkyne with an azide to form a 1,2,3-triazole.1,2 Sources of Cu(I) include copper(I) iodide, copper(I) bromide, copper turnings, or copper (II) sulfate (CuSO4) and a reducing agent.1 However, the ...
- Tris(3-hydroxypropyltriazolylmethyl)amine(THPTA) Tris(3-hydroxypropyltriazolylmethyl)amine (THPTA) is a water-soluble ligand, is widely used to promote Cu-catalyzed alkyneazide cyclization (CuAAC), the typical bioorthogonal reaction with non-interference in living systems.
- The application of click chemistry in chemical ligation and peptide modification Connecting multiple peptide fragments to form an extended peptide chain is referred to as ligation. Click chemistry offers a convenient method for creating peptide-peptide linkages. By introducing an alkyne group to one peptide fragment and an N-terminal azide moiety to another, a triazole ...
- Copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) The azide-alkyne Huisgen cycloaddition is a 1,3-dipolar cycloaddition that involves the reaction between an azide and a terminal or internal alkyne, leading to the formation of a 1,2,3-triazole. Rolf Huisgen was a trailblazer in understanding the wide applicability of this organic reaction.
- Reactions of strained alkenes in click chemistry Strained alkenes leverage strain relief as a motivating factor, enabling their engagement in click reactions. Trans-cycloalkenes, typically cyclooctenes, and other strained alkenes like oxanorbornadiene, participate in click reactions with various counterparts, including azides, tetrazines, and ...
- Strain-promoted alkyne-nitrone cycloaddition (SPANC) SPAAC can be carried out efficiently. On the one hand, the chemical potential energy of azide and alkyne substrates as reactants is very high. Diaryl-strained-cyclooctynes, such as dibenzylcyclooctyne (DIBO), have found application in reacting with 1,3-nitrones in strain-promoted alkyne-nitrone ...
- Strain-promoted azide-alkyne cycloaddition (SPAAC) As a prevalent click reaction, strain-promoted alkyne-azide cycloaddition (SPAAC) operates without the need for metal catalysts, reducing agents, or enduring ligands. Instead, it harnesses the enthalpy liberated from the inherent ring strain of cyclooctyne to facilitate the formation of stable ...
- Potential Applications in Click Chemistry Click Chemistry serves as a potent technique for investigating the intracellular distribution of small molecules. Unveiling the precise cellular destinations of these compounds provides profound insights into their mechanisms of action. This methodology has been extensively employed in various ...
- Click Chemistry in Drug Discovery Among the click chemical reaction family, the most interesting one may be the Cu(I)-catalyzed 1,3-dipolar cycloaddition reaction between terminal alkynes and organic azides (Huisgen reaction) to produce 1,4-disubstituted 1,2,3-triazoles (Scheme 1).As a "good" click reaction, this reaction is ...