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Erlizumab (anti-CD18) - Primary antibody, specific to ITGB2, Human IgG1, NEGATIVE MODULATOR of Integrin beta-2 negative modulator, NEGATIVE MODULATOR of Integrin beta-2 negative modulator

COA COA
    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab183450
Grouped product items
SKU Size
Availability
 Price Qty
Ab183450-100μg
100μg
10
$109.90
Ab183450-1mg
1mg
4
$519.90
Ab183450-5mg
5mg
1
$1,299.90
Ab183450-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,079.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

View related series
Click to view target information: ITGB2
Accession#:P05107 (3) CD18 (6) Gene ID:3689 (3) Integrin beta 2 (1) ITGB2 (4)

Basic Description

Product Name Erlizumab (anti-CD18) - Primary antibody, specific to ITGB2, Human IgG1, NEGATIVE MODULATOR of Integrin beta-2 negative modulator
Synonyms 95 subunit beta antibody | Beta 2 (antigen CD18 (p95) antibody | CD 18 antibody | CD18 antibody | Cell surface adhesion glycoprotein LFA 1/CR3/P150,959 beta subunit precursor) antibody | Cell surface adhesion glycoproteins LFA 1/CR3/p150,95 subunit beta a
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity ITGB2
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type NEGATIVE MODULATOR
Mechanism of action NEGATIVE MODULATOR of Integrin beta-2 negative modulator
Product Description

Erlizumab (anti-CD18) is a humanized monoclonal antibody targeted against Integrin beta-2 and used as a therapy for hemorrhagic shock.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 145 kDa
Purification Method Protein A purified
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 211323-03-4

Associated Targets(Human)

ITGB2 Tclin Integrin beta-2 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
ITGB2 Tclin Integrin beta-2 (0 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ITGB2 Tclin Integrin alpha-M/beta-2 (32 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Erlizumab (anti-CD18) (Ab183450) - Flow Cytometry
Flow Cytometry analysis of Jurkat cells labelling CD18 (red) with Erlizumab (anti-CD18) (Ab183450). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Erlizumab (anti-CD18) (Ab183450) - SEC
The purity of Erlizumab (anti-CD18) (Ab183450) is more than 95% verified by HPLC.

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0708139 Certificate of Analysis Jul 11, 2024 Ab183450
ZJ24F0708138 Certificate of Analysis Jul 11, 2024 Ab183450
ZJ24F0708137 Certificate of Analysis Jul 11, 2024 Ab183450

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