Determine the necessary mass, volume, or concentration for preparing a solution.
This is a demo store. No orders will be fulfilled.
| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
|
Ab183422-100μg
|
100μg |
10
|
$69.90
|
|
|
Ab183422-1mg
|
1mg |
4
|
$349.90
|
|
|
Ab183422-5mg
|
5mg |
1
|
$929.90
|
|
|
Ab183422-10mg
|
10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$1,489.90
|
|
Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Enavatuzumab (anti-TWEAKR) - Primary antibody, specific to TNFRSF12A, Human IgG1, AGONIST of Tumor necrosis factor receptor superfamily member 12A agonist |
|---|---|
| Synonyms | CD 266 antibody | CD266 antibody | CD266 antigen antibody | FGF inducible 14 antibody | FGF-inducible 14 antibody | Fibroblast growth factor inducible immediate early response protein 14 antibody | Fibroblast growth factor-inducible immediate-early respon |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | TNFRSF12A |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | AGONIST |
| Mechanism of action | AGONIST of Tumor necrosis factor receptor superfamily member 12A agonist |
| Product Description |
Enavatuzumab (anti-TWEAKR) is a humanized IgG1 monoclonal antibody targeting the receptor of TNF-like weak inducer of apoptosis (TWEAK). TWEAK (Fn14; TNFRSF12A), the natural ligand of the TWEAK receptor (TweakR), stimulates multiple cellular responses. Enavatuzumab (anti-TWEAKR) induces tumor growth inhibition through direct TweakR signaling and antibody dependent cell-mediated cytotoxicity (ADCC). Enavatuzumab (anti-TWEAKR) can actively recruits and activates myeloid effectors to kill tumor cells. Enavatuzumab (anti-TWEAKR) inhibits the growth of various human TweakR-positive cancer cell lines and xenografts in vitro and in vivo. |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 26.7 kDa (Light Chain) & 51.2 kDa (Heavy Chain), under reducing conditions; 194.1 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 1062149-33-0 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Enavatuzumab (anti-TWEAKR) (Ab183422) - Flow Cytometry
Flow Cytometry analysis of HT-29 cells labelling TWEAKR (red) with Enavatuzumab (anti-TWEAKR) (Ab183422). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Enavatuzumab (anti-TWEAKR) (Ab183422) - Flow Cytometry
Flow Cytometry analysis of MCF-7 cells labelling TWEAKR (red) with Enavatuzumab (anti-TWEAKR) (Ab183422). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Enavatuzumab (anti-TWEAKR) (Ab183422) - SEC
The purity of Enavatuzumab (anti-TWEAKR) (Ab183422) is more than 95% verified by HPLC.
Enavatuzumab (anti-TWEAKR) (Ab183422) - Flow Cytometry
Transfected with Human TWEAKR protein of HEK293 cells were stained with Enavatuzumab (anti-TWEAKR) (Ab183422) and negative control protein respectively, washed and then followed by PE and analyzed with FACS, the EC50 for this effect is 46.94 nM.
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | May 16, 2024 | Ab183422 | |
| Certificate of Analysis | May 16, 2024 | Ab183422 | |
| Certificate of Analysis | May 16, 2024 | Ab183422 |