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Small Molecules & Compound Libraries
Signaling Pathways
GPCR/G Protein
Histamine Receptor
Dimaprit dihydrochloride - 98%, high purity , CAS No.23256-33-9

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Dimaprit dihydrochloride - 98%, high purity , CAS No.23256-33-9

COA

Grade & Purity:

≥98%

Cas Number: 23256-33-9
Molecular Weight: 234.19
PubChem CID: 90045
PubChem SID: 504756013

In stock

Item Number

D275181

Grouped product items
SKU	Size	Availability	Price
D275181-5mg	5mg	2	$16.90
D275181-10mg	10mg	2	$28.90
D275181-25mg	25mg	2	$58.90
D275181-50mg	50mg	2	$98.90
D275181-100mg	100mg	2	$157.90
D275181-200mg	200mg	2	$284.90

Selective H 2 agonist

View related series

Class A GPCR (4138) Immunology/Inflammation (1929) NO Synthase (134)

Basic Description

Synonyms	SR-01000597945-2 \| Dimaprit dihydrochloride, >=98% (NMR) \| 2-(3-Dimethylaminopropyl)-2-thiopseudourea dihydrochloride \| S-(3-Dimethylaminopropyl)isothiourea . 2HCl \| SCHEMBL7174665 \| DTXSID90177831 \| BCP27612 \| TMTD (Tetramethyl-thiuram-disulfide) \| (11E)
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Selective H 2 agonist. Some selectivity for H 3. Does not readily cross the blood-brain barrier. Systemically active following oral administration.The histamine H2 receptor influences various cardiovascular responses, including vasodilation and cardiac rh
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Dimaprit dihydrochloride is a selective histamine H2 receptor agonist. Dimaprit dihydrochloride also inhibits nNOS with an IC50 of 49 μM. It can stimulate gastric acid secretion.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organosulfur compounds
  - Class Isothioureas

Kingdom	Organic compounds
Superclass	Organosulfur compounds
Class	Isothioureas
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Isothioureas
Alternative Parents	Trialkylamines Sulfenyl compounds Carboximidamides Organopnictogen compounds Imines Hydrochlorides Hydrocarbon derivatives
Molecular Framework	Aliphatic acyclic compounds
Substituents	Tertiary aliphatic amine - Tertiary amine - Isothiourea - Sulfenyl compound - Carboximidamide - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Hydrochloride - Organonitrogen compound - Imine - Amine - Aliphatic acyclic compound
Description	This compound belongs to the class of organic compounds known as isothioureas. These are organic compounds containing the isothiourea group, with the general structure R1SC(=NR2)N(R3)R4 (R1,R2,R3,R4=H, alkyl, aryl).
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

HRH4 Tchem Histamine H4 receptor (0 Activities)

Discover Target: HRH4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504756013
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504756013
IUPAC Name	3-(dimethylamino)propyl carbamimidothioate;dihydrochloride
INCHI	InChI=1S/C6H15N3S.2ClH/c1-9(2)4-3-5-10-6(7)8;;/h3-5H2,1-2H3,(H3,7,8);2*1H
InChIKey	DFWCPLGXFMSUCW-UHFFFAOYSA-N
Smiles	CN(C)CCCSC(=N)N.Cl.Cl
Isomeric SMILES	CN(C)CCCSC(=N)N.Cl.Cl
PubChem CID	90045
Molecular Weight	234.19

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot Number	Certificate Type	Date	Item
K2218267	Certificate of Analysis	Sep 15, 2023	D275181
K2218269	Certificate of Analysis	Sep 15, 2023	D275181
K2218271	Certificate of Analysis	Sep 15, 2023	D275181
K2218268	Certificate of Analysis	Sep 15, 2023	D275181
K2218266	Certificate of Analysis	Sep 15, 2023	D275181
K2218265	Certificate of Analysis	Sep 15, 2023	D275181

Chemical and Physical Properties

Solubility	Soluble in water to 100 mM
Molecular Weight	234.190 g/mol
XLogP3
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	5
Exact Mass	233.052 Da
Monoisotopic Mass	233.052 Da
Topological Polar Surface Area	78.400 Å²
Heavy Atom Count	12
Formal Charge	0
Complexity	103.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	3

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