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Demethyl Curcumin - 98%, high purity , CAS No.149732-51-4

COA COA
    Grade & Purity:
  • ≥98%
In stock
Item Number
D345260
Grouped product items
SKU Size
Availability
 Price Qty
D345260-10mg
10mg
5
$67.90
D345260-25mg
25mg
1
$129.90
D345260-50mg
50mg
1
$199.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

a metabolite of Curcumin with potent activity against Trypanosoma and Leishmania

Basic Description

Synonyms 1-(3,4-dihydroxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione | ACon1_000860 | Monodemethylcurcumin | Mono-O-Demethylcurcumin | BDBM50059987 | 422O27405E | (1E,6E)-1-(3,4-Dihydroxy-phenyl)-7-(4-hydroxy-3-methoxy-phenyl)-hepta-1,6-diene-3,
Specifications & Purity ≥98%
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description

Demethyl Curcumin is a metabolite of Curcumin with potent activity against Trypanosoma and Leishmania species.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Phenylpropanoids and polyketides
Class Diarylheptanoids
Subclass Linear diarylheptanoids
Intermediate Tree Nodes Not available
Direct Parent Linear diarylheptanoids
Alternative Parents Hydroxycinnamic acids and derivatives  Methoxyphenols  Anisoles  Catechols  Styrenes  Methoxybenzenes  Phenoxy compounds  1-hydroxy-4-unsubstituted benzenoids  Beta-diketones  Alkyl aryl ethers  1-hydroxy-2-unsubstituted benzenoids  Enones  Acryloyl compounds  Ketones  Hydrocarbon derivatives  Organic oxides  
Molecular Framework Aromatic homomonocyclic compounds
Substituents Linear 1,7-diphenylheptane skeleton - Hydroxycinnamic acid or derivatives - Methoxyphenol - Anisole - Catechol - Phenoxy compound - Phenol ether - Styrene - Methoxybenzene - Phenol - 1,3-diketone - Alkyl aryl ether - 1-hydroxy-2-unsubstituted benzenoid - 1-hydroxy-4-unsubstituted benzenoid - Benzenoid - 1,3-dicarbonyl compound - Monocyclic benzene moiety - Alpha,beta-unsaturated ketone - Enone - Acryloyl-group - Ketone - Ether - Organic oxide - Organooxygen compound - Organic oxygen compound - Carbonyl group - Hydrocarbon derivative - Aromatic homomonocyclic compound
Description This compound belongs to the class of organic compounds known as linear diarylheptanoids. These are diarylheptanoids with an open heptane chain. The two aromatic rings are linked only by the heptane chain.
External Descriptors Not available

Product Properties

pKa pKa: 8.14 (Predicted)

Associated Targets(Human)

HEK293 (82097 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

pol Human immunodeficiency virus type 1 integrase (9041 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mycobacterium tuberculosis (203094 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Trypanosoma brucei brucei (13300 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Leishmania major (2877 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Leishmania mexicana (936 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 488195571
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488195571
IUPAC Name (1E,6E)-1-(3,4-dihydroxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
INCHI InChI=1S/C20H18O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)12-15(21)6-2-13-4-8-17(23)19(25)10-13/h2-11,23-25H,12H2,1H3/b6-2+,7-3+
InChIKey FFRFJIZJLZXEJX-YPCIICBESA-N
Smiles COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)O)O
Isomeric SMILES COC1=C(C=CC(=C1)/C=C/C(=O)CC(=O)/C=C/C2=CC(=C(C=C2)O)O)O
Molecular Weight 354.35
Reaxy-Rn 20297204
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=20297204&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot Number Certificate Type Date Item
E2325716 Certificate of Analysis May 18, 2023 D345260
E2325732 Certificate of Analysis May 18, 2023 D345260
E2325729 Certificate of Analysis May 18, 2023 D345260
E2325714 Certificate of Analysis May 18, 2023 D345260
E2325717 Certificate of Analysis May 18, 2023 D345260
E2325722 Certificate of Analysis May 18, 2023 D345260

Chemical and Physical Properties

Solubility Soluble in DMSO, and methanol.
Melt Point(°C) 183-187° C (dec.)
Molecular Weight 354.400 g/mol
XLogP3 2.900
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 6
Rotatable Bond Count 7
Exact Mass 354.11 Da
Monoisotopic Mass 354.11 Da
Topological Polar Surface Area 104.000 Ų
Heavy Atom Count 26
Formal Charge 0
Complexity 540.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 2
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 2
Covalently-Bonded Unit Count 1

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