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Curcumin analog C1 - 10mM in DMSO, high purity , CAS No.39777-61-2
Basic Description
Synonyms
(1E,4E)-1,5-Bis(2-methoxyphenyl)penta-1,4-dien-3-one | 39777-61-2 | TFEB activator 1 | 41973-42-6 | RPN77612 | Go-Y019 | CHEMBL477053 | 1,5-bis(2-methoxyphenyl)-1,4-pentadien-3-one | NSC97906 | SCHEMBL2744044 | SCHEMBL2744047 | TFEB activator 1; ABM-7612 | BDBM50285603 | MFCD00719
Specifications & Purity
10mM in DMSO
Biochemical and Physiological Mechanisms
TFEB activator 1 is an orally effective, mTOR-independent activator of TFEB. TFEB activator 1 significantly promotes the nuclear translocation of Flag-TFEB with an EC50 of 2167 nM. TFEB activator 1 enhances autophagy without inhibiting the mTOR pathway an
Storage Temp
Store at -80°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description
Information
Curcumin analog C1 (Curcumin analog Compound C1) is a potenttranscription factor EB (TFEB)activator with promise for the prevention or treatment of Alzheimer's disease.
Taxonomic Classification
Kingdom
Organic compounds
Superclass
Benzenoids
Class
Phenol ethers
Subclass
Anisoles
Intermediate Tree Nodes
Not available
Direct Parent
Anisoles
Alternative Parents
Styrenes Phenoxy compounds Methoxybenzenes Alkyl aryl ethers Enones Acryloyl compounds Ketones Organic oxides Hydrocarbon derivatives
Molecular Framework
Aromatic homomonocyclic compounds
Substituents
Phenoxy compound - Anisole - Styrene - Methoxybenzene - Alkyl aryl ether - Monocyclic benzene moiety - Enone - Acryloyl-group - Alpha,beta-unsaturated ketone - Ketone - Ether - Hydrocarbon derivative - Organooxygen compound - Carbonyl group - Organic oxide - Organic oxygen compound - Aromatic homomonocyclic compound
Description
This compound belongs to the class of organic compounds known as anisoles. These are organic compounds containing a methoxybenzene or a derivative thereof.
External Descriptors
Not available
Data sources
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
Mechanism of Action
Action Type
target ID
Target Name
Target Type
Target Organism
Binding Site Name
References
Names and Identifiers
IUPAC Name
(1E,4E)-1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one
INCHI
InChI=1S/C19H18O3/c1-21-18-9-5-3-7-15(18)11-13-17(20)14-12-16-8-4-6-10-19(16)22-2/h3-14H,1-2H3/b13-11+,14-12+
InChIKey
RCZMPCUUTSDNAJ-PHEQNACWSA-N
Smiles
COC1=CC=CC=C1C=CC(=O)C=CC2=CC=CC=C2OC
Isomeric SMILES
COC1=CC=CC=C1/C=C/C(=O)/C=C/C2=CC=CC=C2OC
Molecular Weight
294.34
Reaxy-Rn
2335342
Reaxys-RN_link_address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2335342&ln=
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
Chemical and Physical Properties
Molecular Weight
294.300 g/mol
XLogP3
4.100
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
3
Rotatable Bond Count
6
Exact Mass
294.126 Da
Monoisotopic Mass
294.126 Da
Topological Polar Surface Area
35.500 Ų
Heavy Atom Count
22
Formal Charge
0
Complexity
363.000
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
2
Undefined Bond Stereocenter Count
0
The total count of all stereochemical bonds
2
Covalently-Bonded Unit Count
1
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