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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab176308-100μg
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100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$69.90
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Ab176308-1mg
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1mg |
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
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$339.90
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Ab176308-5mg
|
5mg |
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
|
$869.90
|
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Ab176308-10mg
|
10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$1,389.90
|
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Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Concizumab (anti-TFPI) - Primary antibody, specific to TFPI, >95%, high purity, Human IgG4SP, INHIBITOR of Tissue factor pathway inhibitor inhibitor |
|---|---|
| Synonyms | Anti convertin antibody | EPI antibody | Extrinsic pathway inhibitor antibody | LACI antibody | Lipoprotein associated coagulation inhibitor antibody | Lipoprotein-associated coagulation inhibitor antibody | TFI antibody | TFPI 1 antibody | TFPI antibody |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | TFPI |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | INHIBITOR |
| Mechanism of action | INHIBITOR of Tissue factor pathway inhibitor inhibitor |
| Product Description |
Concizumab (anti-TFPI) is an anti-TFPI monoclonal antibody (IgG4 type) that binds to the Kunitz-type protease inhibitor (KPI) 2 structural domain of TFPI, thereby blocking the interaction of this structural domain with the FXa active site. Concizumab (anti-TFPI) can be used in the study of haemophilia. |
| Isotype | Human IgG4SP |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 27.0 kDa (Light Chain) & 53.5 kDa (Heavy Chain), under reducing conditions; 181.5 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 1312299-39-0 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Concizumab (anti-TFPI) (Ab176308) - Flow Cytometry
Flow Cytometry analysis of HepG2 cells labelling TFPI (red) with Concizumab (anti-TFPI) (Ab176308). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Concizumab (anti-TFPI) (Ab176308) - SEC
The purity of Concizumab (anti-TFPI) (Ab176308) is more than 95% verified by HPLC.
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Nov 02, 2023 | Ab176308 | |
| Certificate of Analysis | Nov 02, 2023 | Ab176308 |
Starting at $109.90
Starting at $109.90