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Concizumab (anti-TFPI) - Primary antibody, specific to TFPI, >95%, high purity, Human IgG4SP, INHIBITOR of Tissue factor pathway inhibitor inhibitor, INHIBITOR of Tissue factor pathway inhibitor inhibitor

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human,Rabbit,Rhesus monkey
  • Isotype: Human IgG4SP
  • Conjugation: Unconjugated
In stock
Item Number
Ab176308
Grouped product items
SKU Size
Availability
Price Qty
Ab176308-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$69.90
Ab176308-1mg
1mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$339.90
Ab176308-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$869.90
Ab176308-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,389.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Concizumab (anti-TFPI) - Primary antibody, specific to TFPI, >95%, high purity, Human IgG4SP, INHIBITOR of Tissue factor pathway inhibitor inhibitor
Synonyms Anti convertin antibody | EPI antibody | Extrinsic pathway inhibitor antibody | LACI antibody | Lipoprotein associated coagulation inhibitor antibody | Lipoprotein-associated coagulation inhibitor antibody | TFI antibody | TFPI 1 antibody | TFPI antibody
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity TFPI
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action INHIBITOR of Tissue factor pathway inhibitor inhibitor
Product Description

Concizumab (anti-TFPI) is an anti-TFPI monoclonal antibody (IgG4 type) that binds to the Kunitz-type protease inhibitor (KPI) 2 structural domain of TFPI, thereby blocking the interaction of this structural domain with the FXa active site. Concizumab (anti-TFPI) can be used in the study of haemophilia.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

Isotype Human IgG4SP
Light Chain Type kappa
SDS-PAGE 27.0 kDa (Light Chain) & 53.5 kDa (Heavy Chain), under reducing conditions; 181.5 kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95%
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 1312299-39-0

Associated Targets(Human)

TFPI Tchem Tissue factor pathway inhibitor (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Concizumab (anti-TFPI) (Ab176308) - Flow Cytometry
Flow Cytometry analysis of HepG2 cells labelling TFPI (red) with Concizumab (anti-TFPI) (Ab176308). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Concizumab (anti-TFPI) (Ab176308) - SEC
The purity of Concizumab (anti-TFPI) (Ab176308) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
ZJ23F1001507 Certificate of Analysis Nov 02, 2023 Ab176308
ZJ23F1001508 Certificate of Analysis Nov 02, 2023 Ab176308

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