Polo-like Kinase (PLK)-Aladdin Scientific

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GSK461364, Serine/threonine-protein kinase PLK1 inhibitor

Grade & Purity:

≥98%

Cas Number: 929095-18-1

Formula: C₂₇H₂₈F₃N₅O₂S Molecular Weight: 543.62

IUPAC Name: 5-[6-[(4-methylpiperazin-1-yl)methyl]benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]thiophene-2-carboxamide

SMILES: CC(C1=CC=CC=C1C(F)(F)F)OC2=C(SC(=C2)N3C=NC4=C3C=C(C=C4)CN5CCN(CC5)C)C(=O)N

InChIKey: ZHJGWYRLJUCMRT-QGZVFWFLSA-N

InChI: InChI=1S/C27H28F3N5O2S/c1-17(19-5-3-4-6-20(19)27(28,29)30)37-23-14-24(38-25(23)26(31)36)35-16-32-21-8-7-18(13-22(21)35)15-34-11-9-33(2)10-12-34/h3-8,1show more

Synonyms: CCG-264940 | GTPL5684 | SW220052-1 | AC-23167 | GSK 461364 | 5-[6-[(4-Methyl-1-piperazinyl)methyl]-1h-benzimidazol-1-...

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Ro3280, Inhibitor of FER tyrosine kinase;Inhibitor of polo like kinase 1;Inhibitor of TTK protein kinase

Grade & Purity:

Moligand™

≥99%

Cas Number: 1062243-51-9 Compound CID: 25015677

Formula: C₂₇H₃₅F₂N₇O₃ Molecular Weight: 543.61

IUPAC Name: 4-[(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-8H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide

SMILES: CN1CCC(CC1)NC(=O)C2=CC(=C(C=C2)NC3=NC=C4C(=N3)N(CC(C(=O)N4C)(F)F)C5CCCC5)OC

InChIKey: DJNZZLZKAXGMMC-UHFFFAOYSA-N

InChI: InChI=1S/C27H35F2N7O3/c1-34-12-10-18(11-13-34)31-24(37)17-8-9-20(22(14-17)39-3)32-26-30-15-21-23(33-26)36(19-6-4-5-7-19)16-27(28,29)25(38)35(21)2/h8-9show more

Synonyms: BCP05205 | HMS3653O21 | PharmaGSID_48511 | 1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid | 4-((9-Cyclope...

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ON-01910

Grade & Purity:

≥98%

Cas Number: 1225497-78-8

Formula: C₂₁H₂₄NO₈S・Na Molecular Weight: 473.43

IUPAC Name: sodium;2-[2-methoxy-5-[[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonylmethyl]anilino]acetate

SMILES: COC1=C(C=C(C=C1)CS(=O)(=O)C=CC2=C(C=C(C=C2OC)OC)OC)NCC(=O)[O-].[Na+]

InChIKey: VLQLUZFVFXYXQE-USRGLUTNSA-M

InChI: InChI=1S/C21H25NO8S.Na/c1-27-15-10-19(29-3)16(20(11-15)30-4)7-8-31(25,26)13-14-5-6-18(28-2)17(9-14)22-12-21(23)24;/h5-11,22H,12-13H2,1-4H3,(H,23,24);/show more

Synonyms: ON-01910Na | ON-019190 (sodium) | rigosertib sodium salt | ON 01910.Na | SODIUM 2-[(2-METHOXY-5-{[2-(2,4,6-TRIMETHOXY...

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MLN0905, Inhibitor of polo like kinase 1

Grade & Purity:

Moligand™

≥97%

Cas Number: 1228960-69-7

Formula: C₂₄H₂₅F₃N₆S Molecular Weight: 486.56

IUPAC Name: 2-[[5-[3-(dimethylamino)propyl]-2-methylpyridin-3-yl]amino]-9-(trifluoromethyl)-5,7-dihydropyrimido[5,4-d][1]benzazepine-6-thione

SMILES: CC1=C(C=C(C=N1)CCCN(C)C)NC2=NC=C3CC(=S)NC4=C(C3=N2)C=CC(=C4)C(F)(F)F

InChIKey: CODBZFJPKJDNDT-UHFFFAOYSA-N

InChI: InChI=1S/C24H25F3N6S/c1-14-19(9-15(12-28-14)5-4-8-33(2)3)31-23-29-13-16-10-21(34)30-20-11-17(24(25,26)27)6-7-18(20)22(16)32-23/h6-7,9,11-13H,4-5,8,10Hshow more

Synonyms: 2-(5-(3-(DIMETHYLAMINO)PROPYL)-2-METHYLPYRIDIN-3-YLAMINO)-9-(TRIFLUOROMETHYL)-5H-BENZO[B]PYRIMIDO[4,5-D]AZEPINE-6(7H)...

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BI 2536, Serine/threonine-protein kinase PLK1 inhibitor

Grade & Purity:

Moligand™

≥98%

Cas Number: 755038-02-9

Formula: C₂₈H₃₉N₇O₃ Molecular Weight: 521.66

IUPAC Name: 4-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide

SMILES: CCC1C(=O)N(C2=CN=C(N=C2N1C3CCCC3)NC4=C(C=C(C=C4)C(=O)NC5CCN(CC5)C)OC)C

InChIKey: XQVVPGYIWAGRNI-JOCHJYFZSA-N

InChI: InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16show more

Synonyms: (R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl...

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HMN-214

Grade & Purity:

≥98%

Cas Number: 173529-46-9

Formula: C₂₂H₂₀N₂O₅S Molecular Weight: 424.48

IUPAC Name: N-(4-methoxyphenyl)sulfonyl-N-[2-[(E)-2-(1-oxidopyridin-1-ium-4-yl)ethenyl]phenyl]acetamide

SMILES: CC(=O)N(C1=CC=CC=C1C=CC2=CC=[N+](C=C2)[O-])S(=O)(=O)C3=CC=C(C=C3)OC

InChIKey: OCKHRKSTDPOHEN-BQYQJAHWSA-N

InChI: InChI=1S/C22H20N2O5S/c1-17(25)24(30(27,28)21-11-9-20(29-2)10-12-21)22-6-4-3-5-19(22)8-7-18-13-15-23(26)16-14-18/h3-16H,1-2H3/b8-7+

Synonyms: BRD-K70511574-001-01-0 | (E)-4-(2-(2-(N-Acetyl-N-((p-methoxyphenyl)sulfonyl)amino)phenyl)ethenyl)pyridine 1-oxide | a...

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SBE 13 hydrochloride

Grade & Purity:

≥98%(HPLC)

Cas Number: 1052532-15-6 Compound CID: 11948807

Formula: C₂₄H₂₈Cl₂N₂O₄ Molecular Weight: 479.4

IUPAC Name: N-[[4-[(6-chloropyridin-3-yl)methoxy]-3-methoxyphenyl]methyl]-2-(3,4-dimethoxyphenyl)ethanamine;hydrochloride

SMILES: COC1=C(C=C(C=C1)CCNCC2=CC(=C(C=C2)OCC3=CN=C(C=C3)Cl)OC)OC.Cl

InChIKey: QBGSVDJLQQXEGG-UHFFFAOYSA-N

InChI: InChI=1S/C24H27ClN2O4.ClH/c1-28-20-7-4-17(12-22(20)29-2)10-11-26-14-18-5-8-21(23(13-18)30-3)31-16-19-6-9-24(25)27-15-19;/h4-9,12-13,15,26H,10-11,14,16show more

Synonyms: AC-3511 | SBE-13 HCl;SBE13 HCl | N-{4-[(6-chloro-3-pyridinyl)methoxy]-3-methoxybenzyl}-N-[2-(3,4-dimethoxyphenyl)ethy...

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LFM-A13

Grade & Purity:

≥98%(HPLC)

Cas Number: 62004-35-7

Formula: C₁₁H₈Br₂N₂O₂ Molecular Weight: 360

IUPAC Name: 2-cyano-N-(2,5-dibromophenyl)-3-hydroxybut-2-enamide

SMILES: CC(=C(C#N)C(=O)NC1=C(C=CC(=C1)Br)Br)O

InChIKey: UVSVTDVJQAJIFG-UHFFFAOYSA-N

InChI: InChI=1S/C11H8Br2N2O2/c1-6(16)8(5-14)11(17)15-10-4-7(12)2-3-9(10)13/h2-4,16H,1H3,(H,15,17)

Synonyms: AKOS028108222 | alpha-Cyano-beta-hydroxy-beta-methyl-N-(2,5-dibromophenyl)propenamide | KBio3_001038 | HMS3370M16 | L...

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Volasertib (BI 6727), Inhibitor of polo like kinase 1

Grade & Purity:

Moligand™

≥97%

Cas Number: 755038-65-4 Compound CID: 10461508

Formula: C₃₄H₅₀N₈O₃ Molecular Weight: 618.83

IUPAC Name: N-[4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexyl]-4-[[(7R)-7-ethyl-5-methyl-6-oxo-8-propan-2-yl-7H-pteridin-2-yl]amino]-3-methoxybenzamide

SMILES: CCC1C(=O)N(C2=CN=C(N=C2N1C(C)C)NC3=C(C=C(C=C3)C(=O)NC4CCC(CC4)N5CCN(CC5)CC6CC6)OC)C

InChIKey: SXNJFOWDRLKDSF-XKHVUIRMSA-N

InChI: InChI=1S/C34H50N8O3/c1-6-28-33(44)39(4)29-20-35-34(38-31(29)42(28)22(2)3)37-27-14-9-24(19-30(27)45-5)32(43)36-25-10-12-26(13-11-25)41-17-15-40(16-18-4show more

Synonyms: BCPP000341 | DTXSID901025694 | Benzamide, N-(trans-4-(4-(cyclopropylmethyl)-1-piperazinyl)cyclohexyl)-4-(((7R)-7-ethy...

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, Inhibitor of mechanistic target of rapamycin kinase;Inhibitor of phosphatidylinositol-4;5-bisphosphate 3-kinase catalytic subunit alpha;Inhibitor of phosphatidylinositol-4;5-bisphosphate 3-kinase catalytic subunit beta;Inhibitor of phosphatidylinositol-4;

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Wortmannin, Inhibitor of mechanistic target of rapamycin kinase;Inhibitor of phosphatidylinositol-4;5-bisphosphate 3-kinase catalytic subunit alpha;Inhibitor of phosphatidylinositol-4;5-bisphosphate 3-kinase catalytic subunit beta;Inhibitor of phosphatidylinositol-4;

Grade & Purity:

Moligand™

≥98%

Cas Number: 19545-26-7 Compound CID: 312145

Formula: C₂₃H₂₄O₈ Molecular Weight: 428.43

IUPAC Name: [(1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-6,11,16-trioxo-13,17-dioxapentacyclo[10.6.1.02,10.05,9.015,19]nonadeca-2(10),12(19),14-trien-3-yl] show more

SMILES: CC(=O)OC1CC2(C(CCC2=O)C3=C1C4(C(OC(=O)C5=COC(=C54)C3=O)COC)C)C

InChIKey: QDLHCMPXEPAAMD-QAIWCSMKSA-N

InChI: InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,show more

Synonyms: BRN 0067676 | SCHEMBL4531 | ST-415 | (1S,6bR,9aS,11R,11bR)-1-(methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-3,6,6b,7,8,...

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Cyclapolin 9

Grade & Purity:

≥98%(HPLC)

Cas Number: 40533-25-3

Formula: C₉H₄F₃N₃O₄S Molecular Weight: 307.21

IUPAC Name: 7-nitro-3-oxido-5-(trifluoromethyl)-1,3-benzothiazol-3-ium-2-carboxamide

SMILES: C1=C(C=C(C2=C1[N+](=C(S2)C(=O)N)[O-])[N+](=O)[O-])C(F)(F)F

InChIKey: FHFLXKUKCSDMLD-UHFFFAOYSA-N

InChI: InChI=1S/C9H4F3N3O4S/c10-9(11,12)3-1-4-6(5(2-3)15(18)19)20-8(7(13)16)14(4)17/h1-2H,(H2,13,16)

Synonyms: 7-Nitro-5-(trifluoromethyl)-2-benzothiazolecarboxamide-3-oxide | 2-carbamoyl-7-nitro-5-(trifluoromethyl)benzo[d]thiaz...

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Poloxime

Cas Number: 17302-61-3

Formula: C₁₀H₁₃NO₂ Molecular Weight: 179.22

IUPAC Name: 5-methyl-4-nitroso-2-propan-2-ylphenol

SMILES: CC1=CC(=C(C=C1N=O)C(C)C)O

InChIKey: YQVCMSSJMLGWAM-UHFFFAOYSA-N

InChI: InChI=1S/C10H13NO2/c1-6(2)8-5-9(11-13)7(3)4-10(8)12/h4-6,12H,1-3H3

Synonyms: DTXSID9062350 | Phenol, 5-methyl-2-(1-methylethyl)-4-nitroso- | 2-Methyl-5-(1-Methylethyl)cyclohexa-2,5-Diene-1,4-Dio...

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