Checkpoint Kinase (Chk)-Aladdin Scientific

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SB 218078, Inhibitor of checkpoint kinase 1

Grade & Purity:

≥98%(HPLC)

Cas Number: 135897-06-2 Compound CID: 3387354

Formula: C₂₄H₁₅N₃O₃ Molecular Weight: 393.39

IUPAC Name: 28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8,10,12,20,22,24,26-nonaene-3,5-dione

SMILES: C1CC2N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N(C1O2)C7=C53)C(=O)NC6=O

InChIKey: OTPNDVKVEAIXTI-UHFFFAOYSA-N

InChI: InChI=1S/C24H15N3O3/c28-23-19-17-11-5-1-3-7-13(11)26-15-9-10-16(30-15)27-14-8-4-2-6-12(14)18(22(27)21(17)26)20(19)24(29)25-23/h1-8,15-16H,9-10H2,(H,25show more

Synonyms: EX-A4201 | HMS3229O08 | J-006782 | AKOS024457167 | S6U3J3UP11 | NCGC00167774-01 | SB218078 | SB-218078 | (15S,18R)-28...

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NSC 109555 ditosylate

Grade & Purity:

≥98%(HPLC)

Cas Number: 66748-43-4 Compound CID: 12449850

Formula: C₁₉H₂₄N₁₀O•2C₇H₈O₃S Molecular Weight: 752.86

IUPAC Name: 1,3-bis[4-[(E)-N-(diaminomethylideneamino)-C-methylcarbonimidoyl]phenyl]urea;4-methylbenzenesulfonic acid

SMILES: CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O.CC(=NN=C(N)N)C1=CC=C(C=C1)NC(=O)NC2=CC=C(C=C2)C(=NN=C(N)N)C

InChIKey: DIQGNVANOSOABS-XMDRLFCYSA-N

InChI: InChI=1S/C19H24N10O.2C7H8O3S/c1-11(26-28-17(20)21)13-3-7-15(8-4-13)24-19(30)25-16-9-5-14(6-10-16)12(2)27-29-18(22)23;2*1-6-2-4-7(5-3-6)11(8,9)10/h3-10show more

Synonyms: DDUG | 2,2'-[Carbonylbis(imino-4,1-phenyleneethylidyne]bishydrazinecarboximidamide) bis(4-methylbenzenesulfonate)

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PF-477736, Inhibitor of checkpoint kinase 1;Inhibitor of checkpoint kinase 2

Grade & Purity:

Moligand™

≥98%

Cas Number: 952021-60-2

Formula: C₂₂H₂₅N₇O₂ Molecular Weight: 419.48

IUPAC Name: (2R)-2-amino-2-cyclohexyl-N-[2-(1-methylpyrazol-4-yl)-9-oxo-3,10,11-triazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13),11-pentaen-6-yl]acetamide

SMILES: CN1C=C(C=N1)C2=C3C=NNC(=O)C4=C3C(=CC(=C4)NC(=O)C(C5CCCCC5)N)N2

InChIKey: NDEXUOWTGYUVGA-LJQANCHMSA-N

InChI: InChI=1S/C22H25N7O2/c1-29-11-13(9-25-29)20-16-10-24-28-21(30)15-7-14(8-17(27-20)18(15)16)26-22(31)19(23)12-5-3-2-4-6-12/h7-12,19,27H,2-6,23H2,1H3,(H,2show more

Synonyms: (2R)-2-amino-2-cyclohexyl-N-[2-(1-methyl-1H-pyrazol-4-yl)-9-oxo-3,10,11-triazatricyclo[6.4.1.0,4,13]trideca-1,4(13),5...

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AZD 7762 hydrochloride

Grade & Purity:

≥98%(HPLC)

Cas Number: 1246094-78-9

Formula: C₁₇H₁₉FN₄O₂S•HCl Molecular Weight: 398.88

IUPAC Name: 3-(carbamoylamino)-5-(3-fluorophenyl)-N-[(3S)-piperidin-3-yl]thiophene-2-carboxamide;hydrochloride

SMILES: C1CC(CNC1)NC(=O)C2=C(C=C(S2)C3=CC(=CC=C3)F)NC(=O)N.Cl

InChIKey: WFZBLOIXZRZEDG-YDALLXLXSA-N

InChI: InChI=1S/C17H19FN4O2S.ClH/c18-11-4-1-3-10(7-11)14-8-13(22-17(19)24)15(25-14)16(23)21-12-5-2-6-20-9-12;/h1,3-4,7-8,12,20H,2,5-6,9H2,(H,21,23)(H3,19,22,show more

Synonyms: MLS006010750 | HY-10992A | SCHEMBL19457662 | 5-(3-Fluoro-phenyl)-3-ureido-thiophene-2-carboxylic acid (S)-piperidin-3...

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LY2603618, Serine/threonine-protein kinase Chk1 inhibitor

Grade & Purity:

Moligand™

≥98%

Cas Number: 911222-45-2

Formula: C₁₈H₂₂BrN₅O₃ Molecular Weight: 436.3

IUPAC Name: 1-[5-bromo-4-methyl-2-[[(2S)-morpholin-2-yl]methoxy]phenyl]-3-(5-methylpyrazin-2-yl)urea

SMILES: CC1=CC(=C(C=C1Br)NC(=O)NC2=NC=C(N=C2)C)OCC3CNCCO3

InChIKey: SYYBDNPGDKKJDU-ZDUSSCGKSA-N

InChI: InChI=1S/C18H22BrN5O3/c1-11-5-16(27-10-13-8-20-3-4-26-13)15(6-14(11)19)23-18(25)24-17-9-21-12(2)7-22-17/h5-7,9,13,20H,3-4,8,10H2,1-2H3,(H2,22,23,24,25show more

Synonyms: AC-32839 | NCGC00343768-01 | AKOS027422721 | Q27088510 | 71803L5F4S | EX-A426 | RABUSERTIB [WHO-DD] | D10397 | 2-(3,4...

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AZD7762, Serine/threonine-protein kinase Chk1 inhibitor

Grade & Purity:

Moligand™

≥98%

Cas Number: 860352-01-8

Formula: C₁₇H₁₉FN₄O₂S Molecular Weight: 362.42

IUPAC Name: 3-(carbamoylamino)-5-(3-fluorophenyl)-N-[(3S)-piperidin-3-yl]thiophene-2-carboxamide

SMILES: C1CC(CNC1)NC(=O)C2=C(C=C(S2)C3=CC(=CC=C3)F)NC(=O)N

InChIKey: IAYGCINLNONXHY-LBPRGKRZSA-N

InChI: InChI=1S/C17H19FN4O2S/c18-11-4-1-3-10(7-11)14-8-13(22-17(19)24)15(25-14)16(23)21-12-5-2-6-20-9-12/h1,3-4,7-8,12,20H,2,5-6,9H2,(H,21,23)(H3,19,22,24)/tshow more

Synonyms: 5D822Y3L1H | H1206 | 4,4'-DIMETHOXYTHIOCARBANILIDE | BS-22319 | C17H19FN4O2S | CCG-264907 | J-502468 | AZD 7762 | BDB...

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CCT 241533 dihydrochloride

Grade & Purity:

≥98%(HPLC)

Cas Number: 1962925-28-5 Compound CID: 137025388

Formula: C₂₃H₂₇FN₄O₄.₂HCl Molecular Weight: 515.41

IUPAC Name: 4-fluoro-2-[4-[[(3S,4R)-4-(2-hydroxypropan-2-yl)pyrrolidin-3-yl]amino]-6,7-dimethoxyquinazolin-2-yl]phenol;dihydrochloride

SMILES: CC(C)(C1CNCC1NC2=NC(=NC3=CC(=C(C=C32)OC)OC)C4=C(C=CC(=C4)F)O)O.Cl.Cl

InChIKey: VCFVLTMSBOZYOU-FXKISCCRSA-N

InChI: InChI=1S/C23H27FN4O4.2ClH/c1-23(2,30)15-10-25-11-17(15)27-21-13-8-19(31-3)20(32-4)9-16(13)26-22(28-21)14-7-12(24)5-6-18(14)29;;/h5-9,15,17,25,29-30H,1show more

Synonyms: (3R,4S)-4-[[2-(5-Fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-α,α-dimethyl-3-pyrrolidinemethanol dihyd...

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CCT245737, Inhibitor of checkpoint kinase 1;Inhibitor of checkpoint kinase 2

Grade & Purity:

Moligand™

10mM in DMSO

Cas Number: 1489389-18-5

Formula: C₁₆H₁₆F₃N₇O Molecular Weight: 379.34

IUPAC Name: 5-[[4-[[(2R)-morpholin-2-yl]methylamino]-5-(trifluoromethyl)pyridin-2-yl]amino]pyrazine-2-carbonitrile

SMILES: C1COC(CN1)CNC2=CC(=NC=C2C(F)(F)F)NC3=NC=C(N=C3)C#N

InChIKey: YBYYWUUUGCNAHQ-LLVKDONJSA-N

InChI: InChI=1S/C16H16F3N7O/c17-16(18,19)12-8-25-14(26-15-9-22-10(4-20)5-24-15)3-13(12)23-7-11-6-21-1-2-27-11/h3,5,8-9,11,21H,1-2,6-7H2,(H2,23,24,25,26)/t11-show more

Synonyms: CCT245737|1489389-18-5|(R)-5-((4-((morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbo...

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CCT245737, Inhibitor of checkpoint kinase 1;Inhibitor of checkpoint kinase 2

Grade & Purity:

Moligand™

≥99%

Cas Number: 1489389-18-5

Formula: C₁₆H₁₆F₃N₇O Molecular Weight: 379.34

IUPAC Name: 5-[[4-[[(2R)-morpholin-2-yl]methylamino]-5-(trifluoromethyl)pyridin-2-yl]amino]pyrazine-2-carbonitrile

SMILES: C1COC(CN1)CNC2=CC(=NC=C2C(F)(F)F)NC3=NC=C(N=C3)C#N

InChIKey: YBYYWUUUGCNAHQ-LLVKDONJSA-N

InChI: InChI=1S/C16H16F3N7O/c17-16(18,19)12-8-25-14(26-15-9-22-10(4-20)5-24-15)3-13(12)23-7-11-6-21-1-2-27-11/h3,5,8-9,11,21H,1-2,6-7H2,(H2,23,24,25,26)/t11-show more

Synonyms: (R)-5-((4-((morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile | (R)5-((4-((Mo...

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CCT241533, Inhibitor of checkpoint kinase 1;Inhibitor of checkpoint kinase 2

Grade & Purity:

Moligand™

Cas Number: 1262849-73-9

Formula: C₂₃H₂₇FN₄O₄ Molecular Weight: 442.48

IUPAC Name: 4-fluoro-2-[4-[[(3S,4R)-4-(2-hydroxypropan-2-yl)pyrrolidin-3-yl]amino]-6,7-dimethoxyquinazolin-2-yl]phenol

SMILES: CC(C)(C1CNCC1NC2=NC(=NC3=CC(=C(C=C32)OC)OC)C4=C(C=CC(=C4)F)O)O

InChIKey: HZASIAXCPXTISQ-NVXWUHKLSA-N

InChI: InChI=1S/C23H27FN4O4/c1-23(2,30)15-10-25-11-17(15)27-21-13-8-19(31-3)20(32-4)9-16(13)26-22(28-21)14-7-12(24)5-6-18(14)29/h5-9,15,17,25,29-30H,10-11H2,show more

Synonyms: A922008 | 4-fluoro-2-[4-[[(3S,4R)-4-(2-hydroxypropan-2-yl)pyrrolidin-3-yl]amino]-6,7-dimethoxyquinazolin-2-yl]phenol ...

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CHIR-124, Inhibitor of checkpoint kinase 1

Grade & Purity:

Moligand™

≥99%

Cas Number: 405168-58-3 Compound CID: 135399748

Formula: C₂₃H₂₂ClN₅O Molecular Weight: 419.91

IUPAC Name: 4-[[(3S)-1-azabicyclo[2.2.2]octan-3-yl]amino]-3-(1H-benzimidazol-2-yl)-6-chloro-1H-quinolin-2-one

SMILES: C1CN2CCC1C(C2)NC3=C(C(=O)NC4=C3C=C(C=C4)Cl)C5=NC6=CC=CC=C6N5

InChIKey: MOVBBVMDHIRCTG-LJQANCHMSA-N

InChI: InChI=1S/C23H22ClN5O/c24-14-5-6-16-15(11-14)21(25-19-12-29-9-7-13(19)8-10-29)20(23(30)28-16)22-26-17-3-1-2-4-18(17)27-22/h1-6,11,13,19H,7-10,12H2,(H,2show more

Synonyms: NCGC00346626-04 | 4-[(3s)-1-Azabicyclo[2.2.2]oct-3-Ylamino]-3-(1h-Benzimidazol-2-Yl)-6-Chloroquinolin-2(1h)-One | (S)...

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Chk2 inhibitor

Grade & Purity:

≥95%

Cas Number: 724708-21-8

Formula: C₁₅H₁₅N₅O₂ Molecular Weight: 295.3

IUPAC Name: 5-(2-amino-4-hydroxy-1H-imidazol-5-yl)-3,4-dihydro-2H-azepino[3,4-b]indol-1-one

SMILES: C1CNC(=O)C2=NC3=CC=CC=C3C2=C1C4=C(N=C(N4)N)O

InChIKey: RZEPRPGFGRQXDI-UHFFFAOYSA-N

InChI: InChI=1S/C15H13N5O2/c16-15-19-11(14(22)20-15)8-5-6-17-13(21)12-10(8)7-3-1-2-4-9(7)18-12/h1-4,22H,5-6H2,(H,17,21)(H3,16,19,20)

Synonyms: 5-(2-Amino-5-oxo-1,5-dihydroimidazol-4-ylidine)-3,4,5,10-2H-azepino[3,4-b]indol-1-one

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