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CCT 241533 dihydrochloride - ≥98%(HPLC), high purity , CAS No.1962925-28-5

COA

Grade & Purity:

≥98%(HPLC)

Cas Number: 1962925-28-5
Molecular Weight: 515.41
PubChem CID: 137025388

In stock

Item Number

C287966

Grouped product items
SKU	Size	Availability	Price	Qty
C287966-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$301.90

Potent Chk2 inhibitor

View related series

Cell Cycle (2830) Cell Cycle/DNA Damage (2602) Checkpoint Kinase (Chk) (28)

Basic Description

Synonyms	(3R,4S)-4-[[2-(5-Fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-α,α-dimethyl-3-pyrrolidinemethanol dihydrochloride
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Potent Chk2 inhibitor (IC50= 3 nM). Shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. Inhibits Chk2 activation in response toetoposide-induced DNA damage in HT29 cells. Blocks ionizing radiation-induced apoptosis of mouse thym
Storage Temp	Room temperature,Desiccated
Shipped In	Normal

Names and Identifiers

IUPAC Name	4-fluoro-2-[4-[[(3S,4R)-4-(2-hydroxypropan-2-yl)pyrrolidin-3-yl]amino]-6,7-dimethoxyquinazolin-2-yl]phenol;dihydrochloride
INCHI	InChI=1S/C23H27FN4O4.2ClH/c1-23(2,30)15-10-25-11-17(15)27-21-13-8-19(31-3)20(32-4)9-16(13)26-22(28-21)14-7-12(24)5-6-18(14)29;;/h5-9,15,17,25,29-30H,10-11H2,1-4H3,(H,26,27,28);2*1H/t15-,17-;;/m1../s1
InChIKey	VCFVLTMSBOZYOU-FXKISCCRSA-N
Smiles	CC(C)(C1CNCC1NC2=NC(=NC3=CC(=C(C=C32)OC)OC)C4=C(C=CC(=C4)F)O)O.Cl.Cl
PubChem CID	137025388
Molecular Weight	515.41

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	Solvent:water, Max Conc. mg/mL: 5.15, Max Conc. mM: 10 with gentle warming; Solvent:DMSO, Max Conc. mg/mL: 51.54, Max Conc. mM: 100

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