Determine the necessary mass, volume, or concentration for preparing a solution.
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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab182712-100μg
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100μg |
10
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$89.90
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Ab182712-1mg
|
1mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$419.90
|
|
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Ab182712-5mg
|
5mg |
1
|
$1,089.90
|
|
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Ab182712-10mg
|
10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$1,739.90
|
|
Purity≥95% (SDS-PAGE&SEC); Endotoxin Level≤1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Vilobelimab (anti-Complement C5) - Primary antibody, specific to C5, Human IgG4SP, INHIBITOR of Complement C5 inhibitor |
|---|---|
| Synonyms | C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 antibody | C5 antibody | C5a anaphylatoxin antibody | C5a antibody | C5b antibody | CO5_HUMAN antibody | Complement C5 alpha'' chain antibody | Complement C5 antibody | Complement component |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | C5 |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | INHIBITOR |
| Mechanism of action | INHIBITOR of Complement C5 inhibitor |
| Product Description |
Vilobelimab (anti-Complement C5) is a monoclonal anti-C5a antibody to the allergen C5a, a pro-inflammatory complement division product that plays a central role in mediating organ dysfunction. Vilobelimab (anti-Complement C5) acts as a C5a inhibitor, inhibiting neutrophil activation, chemotaxis, and reducing inflammatory signalling, and may be used in studies related to sepsis, COVID-19, etc. |
| Isotype | Human IgG4SP |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 27.0 kDa (Light Chain) & 51.5 kDa (Heavy Chain), under reducing conditions; 192.2 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 2250440-41-4 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Vilobelimab (anti-Complement C5) (Ab182712) - ELISA
Immobilized Human Complement C5 Protein at 2.0 μg/mL can bind Vilobelimab (anti-Complement C5) (Ab182712) with the EC₅₀ of 69.06 ng/mL.
Vilobelimab (anti-Complement C5) (Ab182712) - SEC
The purity of Vilobelimab (anti-Complement C5) (Ab182712) is more than 95% verified by HPLC.
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Jul 11, 2024 | Ab182712 | |
| Certificate of Analysis | Jul 11, 2024 | Ab182712 | |
| Certificate of Analysis | Jul 11, 2024 | Ab182712 |
Starting at $89.90
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Starting at $89.90
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Starting at $109.90