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Vilobelimab (anti-Complement C5) - Primary antibody, specific to C5, Human IgG4SP, INHIBITOR of Complement C5 inhibitor, INHIBITOR of Complement C5 inhibitor

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: African green monkey,Human
  • Isotype: Human IgG4SP
  • Conjugation: Unconjugated
In stock
Item Number
Ab182712
Grouped product items
SKU Size
Availability
Price Qty
Ab182712-100μg
100μg
10
$89.90
Ab182712-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$419.90
Ab182712-5mg
5mg
1
$1,089.90
Ab182712-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,739.90

Purity≥95% (SDS-PAGE&SEC); Endotoxin Level≤1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Vilobelimab (anti-Complement C5) - Primary antibody, specific to C5, Human IgG4SP, INHIBITOR of Complement C5 inhibitor
Synonyms C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 antibody | C5 antibody | C5a anaphylatoxin antibody | C5a antibody | C5b antibody | CO5_HUMAN antibody | Complement C5 alpha'' chain antibody | Complement C5 antibody | Complement component
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity C5
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action INHIBITOR of Complement C5 inhibitor
Product Description

Vilobelimab (anti-Complement C5) is a monoclonal anti-C5a antibody to the allergen C5a, a pro-inflammatory complement division product that plays a central role in mediating organ dysfunction. Vilobelimab (anti-Complement C5) acts as a C5a inhibitor, inhibiting neutrophil activation, chemotaxis, and reducing inflammatory signalling, and may be used in studies related to sepsis, COVID-19, etc.
Purity
≥95% (SDS-PAGE&SEC)
Endotoxin Level
≤1.0EU/mg
Protein Function
Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.
Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis).

Product Properties

Isotype Human IgG4SP
Light Chain Type kappa
SDS-PAGE 27.0 kDa (Light Chain) & 51.5 kDa (Heavy Chain), under reducing conditions; 192.2 kDa, under non-reducing conditions.
Purification Method Protein A purified
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 2250440-41-4

Associated Targets(Human)

C5 Tclin Complement C5 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Vilobelimab (anti-Complement C5) (Ab182712) - ELISA
Immobilized Human Complement C5 Protein at 2.0 μg/mL can bind Vilobelimab (anti-Complement C5) (Ab182712) with the EC₅₀ of 69.06 ng/mL.

Vilobelimab (anti-Complement C5) (Ab182712) - SEC
The purity of Vilobelimab (anti-Complement C5) (Ab182712) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0708112 Certificate of Analysis Jul 11, 2024 Ab182712
ZJ24F0708111 Certificate of Analysis Jul 11, 2024 Ab182712
ZJ24F0708110 Certificate of Analysis Jul 11, 2024 Ab182712

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