This is a demo store. No orders will be fulfilled.

Ustekinumab (anti-IL-12&IL-23) - Primary antibody, specific to IL12B; IL23A, Human IgG1, INHIBITOR of Interleukin-12 inhibitor, INHIBITOR of Interleukin-12 inhibitor

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab175693
Grouped product items
SKU Size
Availability
Price Qty
Ab175693-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$59.90
Ab175693-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$279.90
Ab175693-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$929.90
Ab175693-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,489.90

Purity≥95% (SDS-PAGE&SEC); Endotoxin Level≤1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Ustekinumab (anti-IL-12&IL-23) - Primary antibody, specific to IL12B; IL23A, Human IgG1, INHIBITOR of Interleukin-12 inhibitor
Synonyms CLMF antibody | CLMF p35 antibody | CLMF p40 antibody | CLMF1 antibody | CLMF2 antibody | Cytotoxic lymphocyte maturation factor 1, p35 antibody | Cytotoxic lymphocyte maturation factor 2 antibody | Cytotoxic lymphocyte maturation factor 35 kDa subunit an
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity IL12B; IL23A
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action INHIBITOR of Interleukin-12 inhibitor
Product Description

Ustekinumab (anti-IL-12&IL-23) is an anti-IL-12/IL-23 IgG1κ human monoclonal antibodyPurity
Protein Function
IL-12: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.
Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
IL-23: Associates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Product Properties

Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 145.56 kDa
Purification Method Protein A purified
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 815610-63-0

Associated Targets(Human)

IL12B Tclin Interleukin-12 subunit beta (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
IL23A Tclin Interleukin-23 subunit alpha (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
IL12B Tclin Interleukin-12 (0 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
IL12B Tclin Interleukin-23 (0 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Ustekinumab (anti-IL-12&IL-23) (Ab175693) - ELISA
Immobilized Recombinant Human IL-12/IL-23 p40 protein (rp181556) at 1.0 μg/mL can bind Ustekinumab (anti-IL-12&IL-23) (Ab175693) with the EC₅₀ of 20.26 ng/mL.

Ustekinumab (anti-IL-12&IL-23) (Ab175693) - SEC
The purity of Ustekinumab (anti-IL-12&IL-23) (Ab175693) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Solution Calculators

Reviews

Customer Reviews

Shall we send you a message when we have discounts available?

Remind me later

Thank you! Please check your email inbox to confirm.

Oops! Notifications are disabled.