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STX-100 (anti-Integrin aVb6) - Primary antibody, specific to ITGAV; ITGB6, Human IgG1, INHIBITOR of Integrin alpha-V/beta-6 inhibitor, INHIBITOR of Integrin alpha-V/beta-6 inhibitor

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab182704
Grouped product items
SKU Size
Availability
Price Qty
Ab182704-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$109.90
Ab182704-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$519.90
Ab182704-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,299.90
Ab182704-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,079.90

Purity≥95% (SDS-PAGE&SEC); Endotoxin Level≤1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name STX-100 (anti-Integrin aVb6) - Primary antibody, specific to ITGAV; ITGB6, Human IgG1, INHIBITOR of Integrin alpha-V/beta-6 inhibitor
Synonyms antigen identified by monoclonal antibody L230 antibody | CD 51 antibody | CD51 antibody | DKFZp686A08142 antibody | Integrin alpha five antibody | integrin alpha V beta 3 antibody | Integrin alpha-5 antibody | integrin alpha-V antibody | Integrin alpha-V
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity ITGAV; ITGB6
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action INHIBITOR of Integrin alpha-V/beta-6 inhibitor
Product Description

STX-100 (anti-Integrin aVb6 (ITGAV & ITGB6)) is a humanized monoclonal antibody directed against the alpha v beta 6 (αvβ6) integrin. It has a potential to be used in research on Idiopathic Pulmonary Fibrosis (IPF).
Purity
≥95% (SDS-PAGE&SEC)
Endotoxin Level
≤1.0EU/mg
Protein Function
ITGAV: The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
ITGB6: Integrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion.

Product Properties

Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 145.12 kDa
Purification Method Protein A purified
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 1439902-67-6

Associated Targets(Human)

ITGB6 Tbio Integrin beta-6 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
ITGAV Tchem Integrin alpha-V (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
ITGAV Tchem Vitronectin receptor alpha (65 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ITGAV Tchem Integrin alpha-V/beta-5 (589 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ITGAV Tchem Integrin alpha-V/beta-6 (509 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ITGAV Tchem Integrin alpha-V/beta-8 (181 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

STX-100 (anti-Integrin aVb6) (Ab182704) - Flow Cytometry
Flow Cytometry analysis of MCF-7 cells labelling Integrin aVb6 (red) with STX-100 (anti-Integrin aVb6) (Ab182704) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

STX-100 (anti-Integrin aVb6) (Ab182704) - ELISA
Immobilized Human Integrin alpha V beta 6 (ITGAV&ITGB6) at 2.0 μg/mL can bind STX-100 (anti-Integrin aVb6) (Ab182704) with the EC₅₀ of 131.5 ng/mL.

STX-100 (anti-Integrin aVb6) (Ab182704) - SEC
The purity of STX-100 (anti-Integrin aVb6) (Ab182704) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Solution Calculators

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