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Rovelizumab (anti-CD11a&CD18) - Primary antibody, specific to ITGAL; ITGB2, Human IgG4, Antibody of integrin; alpha L subunit (antigen CD11A (p180); lymphocyte function-associated antigen 1; alpha polypeptide);Antibody of integrin; beta 2 subunit (complem, Antibody of integrin; alpha L subunit (antigen CD11A (p180); lymphocyte function-associated antigen 1; alpha polypeptide);Antibody of integrin; beta 2 subunit (complement component 3 receptor 3 and 4 subunit)

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human
  • Isotype: Human IgG4
  • Conjugation: Unconjugated
In stock
Item Number
Ab175649
Grouped product items
SKU Size
Availability
Price Qty
Ab175649-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$69.90
Ab175649-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$339.90
Ab175649-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$869.90
Ab175649-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,379.90

Purity≥95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Rovelizumab (anti-CD11a&CD18) - Primary antibody, specific to ITGAL; ITGB2, Human IgG4, Antibody of integrin; alpha L subunit (antigen CD11A (p180); lymphocyte function-associated antigen 1; alpha polypeptide);Antibody of integrin; beta 2 subunit (complem
Synonyms Lymphocyte function associated antigen, type 1, alpha subunit antibody | Antigen CD11A (p180), lymphocyte function associated antigen 1, alpha polypeptide antibody | Antigen CD11A antibody | CD 11a antibody | CD11 antigen-like family member A antibody | C
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Biochemical and Physiological Mechanisms CD11a: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granuloc
Host species Human
Specificity ITGAL; ITGB2
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type ANTAGONIST
Mechanism of action Antibody of integrin; alpha L subunit (antigen CD11A (p180); lymphocyte function-associated antigen 1; alpha polypeptide);Antibody of integrin; beta 2 subunit (complement component 3 receptor 3 and 4 subunit)
Product Description

Rovelizumab (anti-CD11a&CD18) is a humanized monoclonal leukointegrin antibody. Rovelizumab (anti-CD11a&CD18) is a monoclonal antibody directed against the CD11/CD18 cell adhesion proteins. Rovelizumab (anti-CD11a&CD18) can be used for research of multiple sclerosis (MS), hemorrhagic shock, myocardial infarction (MI) and stroke.

Product Properties

Isotype Human IgG4
Light Chain Type kappa
SDS-PAGE 145.98 kDa
Purification Method Protein A purified
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS 339086-79-2

Associated Targets(Human)

ITGB2 Tclin Integrin beta-2 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
ITGAL Tclin Integrin alpha-L (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
ITGAL Tclin Leukocyte adhesion glycoprotein LFA-1 alpha (170 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ITGB2 Tclin Integrin beta-2 (0 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ITGAL Tclin Intercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2 (760 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ITGB2 Tclin Integrin alpha-M/beta-2 (32 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ITGAL Tclin Integrin alpha-L/beta-2 (LFA-1) (51 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Solution Calculators

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