Natalizumab (anti-ITGA4) - Primary antibody, specific to ITGA4, Human IgG4, Antibody of integrin α4β1;Antibody of integrin; alpha 4 subunit (antigen CD49D; alpha 4 subunit of VLA-4 receptor), Antibody of integrin α4β1;Antibody of integrin; alpha 4 subunit (antigen CD49D; alpha 4 subunit of VLA-4 receptor)
Natalizumab (anti-ITGA4) - Primary antibody, specific to ITGA4, Human IgG4, Antibody of integrin α4β1;Antibody of integrin; alpha 4 subunit (antigen CD49D; alpha 4 subunit of VLA-4 receptor), Antibody of integrin α4β1;Antibody of integrin; alpha 4 subunit (antigen CD49D; alpha 4 subunit of VLA-4 receptor)
Natalizumab (anti-ITGA4) - Primary antibody, specific to ITGA4, Human IgG4, Antibody of integrin α4β1;Antibody of integrin; alpha 4 subunit (antigen CD49D; alpha 4 subunit of VLA-4 receptor)
Synonyms
269C wild type antibody | Antigen CD49D, alpha 4 subunit of VLA 4 receptor antibody | CD49 antigen like family member D antibody | CD49 antigen-like family member D antibody | CD49d antibody | IA4 antibody | Integrin alpha 4 antibody | Integrin alpha 4 su
Specifications & Purity
Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Antibody of integrin α4β1;Antibody of integrin; alpha 4 subunit (antigen CD49D; alpha 4 subunit of VLA-4 receptor)
Product Description
Natalizumab (anti-ITGA4) is a recombinant, humanized IgG4 monoclonal antibody, binds to α4β1-integrin and blocks its interaction with vascular cell adhesion molecule-1 (VCAM-1). Natalizumab (anti-ITGA4) can be used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease. Natalizumab (anti-ITGA4) is also the first targeted therapy which blocks an essential mechanism for lymphocyte entry to the CNS and thus prevents acute demyelinating relapses. Purity >95% (SDS-PAGE&SEC) Endotoxin Level < 1.0EU/mg
This compound belongs to the class of organic compounds known as oligopeptides. These are organic compounds containing a sequence of between three and ten alpha-amino acids joined by peptide bonds.
External Descriptors
Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Natalizumab (anti-ITGA4) (Ab175611) - Flow Cytometry Flow Cytometry analysis of Jurkat cells labelling ITGA4 (red) with Natalizumab (anti-ITGA4) (Ab175611). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Natalizumab (anti-ITGA4) (Ab175611) - SEC The purity of Natalizumab (anti-ITGA4) (Ab175611) is more than 95% verified by HPLC.
Natalizumab (anti-ITGA4) (Ab175611) - Flow Cytometry Flow Cytometry analysis of Raji cells labelling ITGA4 (red) with Natalizumab (anti-ITGA4) (Ab175611). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Natalizumab (anti-ITGA4) (Ab175611) - Flow Cytometry Flow Cytometry analysis of U937 cells labelling ITGA4 (red) with Natalizumab (anti-ITGA4) (Ab175611). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Natalizumab (anti-ITGA4) (Ab175611) - Flow Cytometry Flow Cytometry analysis of HeLa cells labelling ITGA4 (red) with Natalizumab (anti-ITGA4) (Ab175611). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
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ZJ24F0606633