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DR5/CD262 Armenian Hamster mAb - Primary antibody, specific to DR5/CD262, Armenian Hamster IgG

COA COA
    Application:
  • Activation
  • Animal Model
  • Flow Cytometry
  • Functional Assay
  • Host species: Armenian hamster
  • Reactive species: Mouse
  • Isotype: Armenian Hamster IgG
  • Clone Number: MD5-1
  • Conjugation: Unconjugated
In stock
Item Number
Ab100457
Grouped product items
SKU Size
Availability
 Price Qty
Ab100457-10μg
10μg
5
$29.90
Ab100457-50μg
50μg
2
$69.90
Ab100457-100μg
100μg
1
$99.90
Ab100457-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$699.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

mAb (MD5-1); Armenian Hamster anti Mouse DR5/CD262 Antibody; Flow, in vitro induction TRAIL-mediated apoptosis, in vivo induction TRAIL-mediated apoptosis; Unconjugated

View related series
Click to view target information: TNFRSF10A Click to view target information: TNFRSF10B
Accession#: Q9QZM4 (1) CD262 (9) DR5 (9) Flow Cytometry (1158) Gene ID: 21933 (1)

Basic Description

Product Name DR5/CD262 Armenian Hamster mAb - Primary antibody, specific to DR5/CD262, Armenian Hamster IgG
Synonyms MK | Ly98 | KILLER | TRICK2B | CD262 antigen | CD262 | death domain containing receptor for TRAIL/Apo-2L | Death receptor 5 | DR5 | DR5TRICK2B | Fas-like protein | KILLER/DR5 | KILLERapoptosis inducing protein TRICK2A/2B | TNF-related apoptosis-inducing l
Specifications & Purity Carrier Free, Azide Free, Validated, ≥95%(SDS-PAGE), See COA
Host species Armenian hamster
Specificity DR5/CD262
Immunogen Mouse DR5-Ig fusion protein
Conjugation Unconjugated
Grade Azide Free, Carrier Free, Validated
Product Description

Armenian Hamster anti Mouse DR5/CD262 Antibody, Monoclonal (MD5-1), could be used for Flow, in vitro induction TRAIL-mediated apoptosis, in vivo induction TRAIL-mediated apoptosis and so on.
Application:
Flow: Use at an assay dependent concentration.
in vitro induction TRAIL-mediated apoptosis: Use at an assay dependent concentration.
in vivo induction TRAIL-mediated apoptosis: Use at an assay dependent concentration.
Protein Function
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.

Product Properties

Isotype Armenian Hamster IgG
Light Chain Type kappa
SDS-PAGE 150 kDa
Purification Method Protein G purified
Shape Liquid
Concentration See COA
Storage Temp Store at 2-8°C,Do not freeze
Shipped In Wet ice
Stability And Storage Shipped at 4°C. Store at 4°C long term (12 months). Do not freeze. Upon receipt, it is recommended to aliquot.

Associated Targets(Human)

TNFRSF10A Tchem Tumor necrosis factor receptor superfamily member 10A (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
TNFRSF10B Tbio Tumor necrosis factor receptor superfamily member 10B (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
TNFRSF10A Tchem TRAIL receptor-1 (4 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

DR5/CD262 Armenian Hamster mAb (Ab100457) - Flow Cytometry
Flow Cytometry analysis of 2.5 μg/mL Con A stimulated mouse splenocytes cells (72h) labelling DR5/CD262 with DR5/CD262 Armenian Hamster mAb (Ab100457) conjugated with biotin (right panel) at 5.0 μg/mL for 1 hour at 4°C, compared with Armenian Hamster IgG Isotype Control Antibody (Biotin) (Ab135991) (left panel) and detected with SA-PE (rp156150).

DR5/CD262 Armenian Hamster mAb (Ab100457) - Flow Cytometry
Flow Cytometry analysis of 2.5 μg/mL Con A stimulated mouse splenocytes cells (72h) labelling DR5/CD262 (red) with DR5/CD262 Armenian Hamster mAb (Ab100457) conjugated with biotin at 5.0 μg/mL for 1 hour at 4°C, and detected with SA-PE (rp156150). Blue - Armenian Hamster IgG Isotype Control Antibody (Biotin) (Ab135991). Black - Unlabelled control, cells without incubation with primary antibody.

Application

Application Dilution info
Flow Cytometry

Use at an assay dependent concentration.
in vitro induction TRAIL-mediated apoptosis

Use at an assay dependent concentration.
in vivo induction TRAIL-mediated apoptosis

Use at an assay dependent concentration.

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

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