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Benufutamab (anti-TNFRSF10B) - Primary antibody, specific to TNFRSF10B, Human IgG1

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human,Mouse,Rhesus monkey
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab191894
Grouped product items
SKU Size
Availability
Price Qty
Ab191894-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$99.90
Ab191894-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$479.90
Ab191894-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,429.90
Ab191894-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,289.90

Purity≥95% (SDS-PAGE&SEC); Endotoxin Level≤1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Benufutamab (anti-TNFRSF10B) - Primary antibody, specific to TNFRSF10B, Human IgG1
Synonyms Fas like protein antibody | Apoptosis inducing protein TRICK2A/2B antibody | Apoptosis inducing receptor TRAIL R2 antibody | CD262 antibody | CD262 antigen antibody | Cytotoxic TRAIL receptor 2 antibody | Death domain containing receptor for TRAIL/Apo 2L
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Biochemical and Physiological Mechanisms Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade
Host species Human
Specificity TNFRSF10B
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Product Description

Benufutamab (anti-TNFRSF10B) is a death receptor 5 (DR5)-specific agonistic antibody. Benufutamab (anti-TNFRSF10B) is a mixture of 2 noncompeting DR5-specific IgG1 antibodies, each with an E430G mutation in the Fc domain. Benufutamab (anti-TNFRSF10B) has antitumor effects.

Product Properties

Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 145 kDa
Purification Method Protein A purified
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 2109730-69-8

Associated Targets(Human)

TNFRSF10B Tbio Tumor necrosis factor receptor superfamily member 10B (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Benufutamab (anti-TNFRSF10B) (Ab191894) - Flow Cytometry
Flow Cytometry analysis of Jurkat cells labelling TNFRSF10B (red) with Benufutamab (anti-TNFRSF10B) (Ab191894) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Benufutamab (anti-TNFRSF10B) (Ab191894) - SEC
The purity of Benufutamab (anti-TNFRSF10B) (Ab191894) is more than 95% verified by HPLC.

Benufutamab (anti-TNFRSF10B) (Ab191894) - ELISA
Immobilized Recombinant Human TRAIL R2/TNFRSF10B protein (rp145269) at 0.5 μg/mL can bind Benufutamab (anti-TNFRSF10B) (Ab191894) with the EC50 of 271.1 ng/mL.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

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