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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab209758-100μg
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100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$109.90
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Ab209758-1mg
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1mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$509.90
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Ab209758-5mg
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5mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$1,399.90
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Ab209758-10mg
|
10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$2,299.90
|
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Purity≥90% (SDS-PAGE&SEC-HPLC); Endotoxin Level<1.0 EU/mg; Human IgG1-REM-FEA; CHO; ELISA, Flow Cytometry, Functional assay, Animal Model; Unconjugated
| Product Name | Abbott patent anti-NGR (anti-NGR) - Primary antibody, specific to RTN4R, Human IgG2SA |
|---|---|
| Synonyms | NgR antibody | Nogo 66 receptor antibody | Nogo receptor antibody | Nogor antibody | Reticulon 4 receptor antibody | Rtn4r antibody | UNQ330/PRO526 antibody | NgR | NgR1 | Nogo R | Nogo receptor | Nogo-66 receptor | NogoR | Anti-Nogo Receptor/NgR Antibody |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥90%(SDS-PAGE&SEC-HPLC), See COA |
| Biochemical and Physiological Mechanisms | 4-1BB: Receptor for TNFSF14/4-1BBL. Possibly active during T cell activation. PD-L1: Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction |
| Host species | Human |
| Specificity | RTN4R |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Product Description |
Acasunlimab (anti-4-1BB&PD-L1) is a bispecific antibody (bsAb) targeting PD-L1 and 4-1BB. Acasunlimab (anti-4-1BB&PD-L1) enhances T-cell and NK-cell function through conditional 4-1BB stimulation while constitutively blocking the PD-1/PD-L1 inhibitory axis. Acasunlimab (anti-4-1BB&PD-L1) can be used in research of cancer.
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| Isotype | Human IgG2SA |
|---|---|
| Light Chain Type | lambdaC2 |
| SDS-PAGE | 150 kDa |
| Purification Method | Protein A purified |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Abbott patent anti-NGR (anti-NGR) (Ab209758) - Flow Cytometry
Flow Cytometry analysis of pLVX-puro-Q9BZR6-hu-Nogo Receptor/NgR/RTN4R-FL cells labelling NGR at 1×105 cell/well can bind Abbott patent anti-NGR (anti-NGR) (Ab209758), with the EC50 is 0.099 nM.
Abbott patent anti-NGR (anti-NGR) (Ab209758) - SEC
The purity of Abbott patent anti-NGR (anti-NGR) (Ab209758) is more than 95% verified by HPLC.