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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab175487-100μg
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100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$59.90
|
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Ab175487-1mg
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1mg |
5
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$259.90
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Ab175487-5mg
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5mg |
1
|
$749.90
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Ab175487-10mg
|
10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$1,189.90
|
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Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Carotuximab (anti-CD105) - Primary antibody, specific to ENG, >95%, high purity, Human IgG1, Antibody of endoglin (CD105) |
|---|---|
| Synonyms | AI528660 antibody | AI662476 antibody | CD 105 antibody | CD105 antibody | CD105 antigen antibody | EGLN_HUMAN antibody | END antibody | Endoglin antibody | Eng antibody | FLJ41744 antibody | HHT1 antibody | ORW antibody | ORW1 antibody | Osler Rendu Webe |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | ENG |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | INHIBITOR |
| Mechanism of action | Antibody of endoglin (CD105) |
| Product Description |
Carotuximab (anti-CD105) is a IgG1 monoclonal antibody that blocks endoglin (CD105) and its downstream Smad signaling pathway. Carotuximab (anti-CD105) has immunomodulatory and antineoplastic actions. |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 25.8 kDa (Light Chain) & 49.7 kDa (Heavy Chain), under reducing conditions; 191.0 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 1268714-50-6 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Carotuximab (anti-CD105) (Ab175487) - Flow Cytometry
Flow Cytometry analysis of HUVEC cells labelling CD105 (red) with Carotuximab (anti-CD105) (Ab175487). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Carotuximab (anti-CD105) (Ab175487) - SEC
The purity of Carotuximab (anti-CD105) (Ab175487) is more than 95% verified by HPLC.
Carotuximab (anti-CD105) (Ab175487) - ELISA
Immobilized Recombinant human CD105 protein (rp169605) at 1.0 μg/mL can bind Carotuximab (anti-CD105) (Ab175487) with the EC50 of 31.4 ng/mL.
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Jun 26, 2024 | Ab175487 | |
| Certificate of Analysis | Dec 26, 2023 | Ab175487 | |
| Certificate of Analysis | Dec 26, 2023 | Ab175487 |
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