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Carotuximab (anti-CD105) - Primary antibody, specific to ENG, >95%, high purity, Human IgG1, Antibody of endoglin (CD105), Antibody of endoglin (CD105)

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab175487
Grouped product items
SKU Size
Availability
Price Qty
Ab175487-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$59.90
Ab175487-1mg
1mg
5
$259.90
Ab175487-5mg
5mg
1
$749.90
Ab175487-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,189.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Carotuximab (anti-CD105) - Primary antibody, specific to ENG, >95%, high purity, Human IgG1, Antibody of endoglin (CD105)
Synonyms AI528660 antibody | AI662476 antibody | CD 105 antibody | CD105 antibody | CD105 antigen antibody | EGLN_HUMAN antibody | END antibody | Endoglin antibody | Eng antibody | FLJ41744 antibody | HHT1 antibody | ORW antibody | ORW1 antibody | Osler Rendu Webe
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity ENG
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action Antibody of endoglin (CD105)
Product Description

Carotuximab (anti-CD105) is a IgG1 monoclonal antibody that blocks endoglin (CD105) and its downstream Smad signaling pathway. Carotuximab (anti-CD105) has immunomodulatory and antineoplastic actions.

Product Properties

Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 25.8 kDa (Light Chain) & 49.7 kDa (Heavy Chain), under reducing conditions; 191.0 kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95%
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 1268714-50-6

Associated Targets(Human)

ENG Tbio Endoglin (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Carotuximab (anti-CD105) (Ab175487) - Flow Cytometry
Flow Cytometry analysis of HUVEC cells labelling CD105 (red) with Carotuximab (anti-CD105) (Ab175487). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Carotuximab (anti-CD105) (Ab175487) - SEC
The purity of Carotuximab (anti-CD105) (Ab175487) is more than 95% verified by HPLC.

Carotuximab (anti-CD105) (Ab175487) - ELISA
Immobilized Recombinant human CD105 protein (rp169605) at 1.0 μg/mL can bind Carotuximab (anti-CD105) (Ab175487) with the EC50 of 31.4 ng/mL.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0607384 Certificate of Analysis Jun 26, 2024 Ab175487
ZJ23F1202227 Certificate of Analysis Dec 26, 2023 Ab175487
ZJ23F1202228 Certificate of Analysis Dec 26, 2023 Ab175487

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