Basic Description

Synonyms	Water-soluble CuAAC ligand \| 2-(4-((Bis((1-(tert-butyl)-1H-1,2,3-triazol-4-yl)methyl)amino)methyl)-1H-1,2,3-triazol-1-yl)acetic acid \| Copper click-chemistry ligand
Specifications & Purity	≥99%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	application： BTTAA is a next-generation, water-soluble ligand for the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) that dramatically accelerates reaction rates and suppresses cell cytotoxicity. The biocompatibility and fast kinetics of BTTAA are advancements from water-insoluble TBTA and are desirable for bio conjugation in diverse chemical biology experiments. description： BTTAA is a Cu(I)-stabilizing ligand, whch performs potently with ubiquitin Glu18AzF. BTTAA is a Cu(I)-stabilizing ligand. Using the Glu18AzF mutant of ubiquitin as a model system with C3-Tm3+ and C4-Tm3+, Cu-BTTAA performs significantly better as a catalyst than Cu-THPTA or Cu-TBTA. BTTAA proves to perform much better than THPTA (tris[(1-hydroxy-propyl-1H-1,2,3-triazol-4-yl)methyl]amine) or TBTA (tris[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl]amine)

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic acids and derivatives
  - Class Carboxylic acids and derivatives
    - Subclass Amino acids, peptides, and analogues
      - Level5 Amino acids and derivatives
        Level6 Alpha amino acids and derivatives

Kingdom	Organic compounds
Superclass	Organic acids and derivatives
Class	Carboxylic acids and derivatives
Subclass	Amino acids, peptides, and analogues
Intermediate Tree Nodes	Amino acids and derivatives
Direct Parent	Alpha amino acids and derivatives
Alternative Parents	Aralkylamines Triazoles Heteroaromatic compounds Trialkylamines Amino acids Monocarboxylic acids and derivatives Carboxylic acids Azacyclic compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Alpha-amino acid or derivatives - Aralkylamine - Azole - 1,2,3-triazole - Heteroaromatic compound - Tertiary amine - Tertiary aliphatic amine - Amino acid - Organoheterocyclic compound - Monocarboxylic acid or derivatives - Carboxylic acid - Azacycle - Organic oxide - Amine - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Carbonyl group - Organic oxygen compound - Hydrocarbon derivative - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as alpha amino acids and derivatives. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon), or a derivative thereof.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

Pubchem Sid	488201738
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488201738
IUPAC Name	2-[4-[[bis[(1-tert-butyltriazol-4-yl)methyl]amino]methyl]triazol-1-yl]acetic acid
INCHI	InChI=1S/C19H30N10O2/c1-18(2,3)28-11-15(21-24-28)8-26(7-14-10-27(23-20-14)13-17(30)31)9-16-12-29(25-22-16)19(4,5)6/h10-12H,7-9,13H2,1-6H3,(H,30,31)
InChIKey	MGQYHUDOWOGSQI-UHFFFAOYSA-N
Smiles	CC(C)(C)N1C=C(N=N1)CN(CC2=CN(N=N2)CC(=O)O)CC3=CN(N=N3)C(C)(C)C
Isomeric SMILES	CC(C)(C)N1C=C(N=N1)CN(CC2=CN(N=N2)CC(=O)O)CC3=CN(N=N3)C(C)(C)C
Molecular Weight	430.51
Reaxy-Rn	21841214
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=21841214&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

22 results found

Lot Number	Certificate Type	Date	Item
J2410528	Certificate of Analysis	Sep 25, 2024	B302414
J2410530	Certificate of Analysis	Sep 25, 2024	B302414
J2410532	Certificate of Analysis	Sep 25, 2024	B302414
J2410526	Certificate of Analysis	Sep 25, 2024	B302414
J2410535	Certificate of Analysis	Sep 25, 2024	B302414
J2410541	Certificate of Analysis	Sep 25, 2024	B302414
B2423704	Certificate of Analysis	Feb 01, 2024	B302414
B2423705	Certificate of Analysis	Feb 01, 2024	B302414
B2423713	Certificate of Analysis	Feb 01, 2024	B302414
B2423734	Certificate of Analysis	Feb 01, 2024	B302414
B2423703	Certificate of Analysis	Feb 01, 2024	B302414
B23021029	Certificate of Analysis	Jan 03, 2023	B302414
B23021003	Certificate of Analysis	Jan 03, 2023	B302414
B23021002	Certificate of Analysis	Jan 03, 2023	B302414
B2421048	Certificate of Analysis	Jan 03, 2023	B302414
L2314045	Certificate of Analysis	Jan 03, 2023	B302414
B23021024	Certificate of Analysis	Jan 03, 2023	B302414
B23021038	Certificate of Analysis	Jan 03, 2023	B302414
B23021037	Certificate of Analysis	Jan 03, 2023	B302414
B23021138	Certificate of Analysis	Jan 03, 2023	B302414
B2302995	Certificate of Analysis	Jan 03, 2023	B302414
H2219155	Certificate of Analysis	Aug 24, 2022	B302414

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