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ARGX-117 (anti-Complement C2) - Primary antibody, specific to C2, Human IgG1

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab190121
Grouped product items
SKU Size
Availability
Price Qty
Ab190121-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$59.90
Ab190121-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$279.90
Ab190121-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$719.90
Ab190121-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,149.90

Purity≥95% (SDS-PAGE&SEC); Endotoxin Level≤1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name ARGX-117 (anti-Complement C2) - Primary antibody, specific to C2, Human IgG1
Synonyms C2 antibody | ARMD14 antibody | C3/C5 convertase antibody | CO2 antibody | CO2_HUMAN antibody | Complement C2 antibody | Complement C2a fragment antibody | complement component 2 antibody | DKFZp779M0311 antibody | C2 | C3/C5 convertase | CO2 | complement
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity C2
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Product Description

ARGX-117 (anti-Complement C2) a humanized inhibitory monoclonal antibody against complement C2. ARGX-117 (anti-Complement C2) prevents the formation of the C3 proconvertase and inhibits classical and lectin pathway activation upstream of C3 activation through binding to the Sushi-2 domain of C2. ARGX-117 (anti-Complement C2) exhibits pH- and calcium-dependent target binding. ARGX-117 (anti-Complement C2) prevents complement-mediated cytotoxicity in in vitro models for autoimmune hemolytic anemia and antibody-mediated rejection of organ transplants.
Purity
≥95% (SDS-PAGE&SEC)
Endotoxin Level
≤1.0EU/mg
Protein Function
Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor 4b to generate the C3 or C5 convertase.

Product Properties

Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 146.12 kDa
Purification Method Protein A purified
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 2579031-19-7

Associated Targets(Human)

C2 Tchem Complement C2 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

ARGX-117 (anti-Complement C2) (Ab190121) - ELISA
Immobilized Human Complement C2 Protein at 2.0 μg/mL can bind ARGX-117 (anti-Complement C2) (Ab190121) with the EC ₅₀ of 41.04 ng/mL.

ARGX-117 (anti-Complement C2) (Ab190121) - SEC
The purity of ARGX-117 (anti-Complement C2) (Ab190121) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Solution Calculators

Reviews

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