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Ampicillin trihydrate - 10mM in DMSO, high purity , CAS No.7177-48-2

198 Citations COA COA
    Grade & Purity:
  • 10mM in DMSO
  • Cas Number:  7177-48-2
  • Molecular Weight:  403.45
  • PubChem CID: 23565
In stock
Item Number
A425643
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A425643-1ml
1ml
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$69.90
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Antibiotic (1629) Bacterial (3013) Compound libraries (12325)

Basic Description

Synonyms 615-347-9 | 7177-48-2 | Ampicillin trihydrate | Aminobenzylpenicillin trihydrate | Penbritin | AMPICILLIN/AMPICILLIN TRIHYDRATE | HXQ6A1N7R6 | Ampicillin (trihydrate) | (2S,5R,6R)-6-((R)-2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-ca
Specifications & Purity 10mM in DMSO
Storage Temp Store at -80°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Lactams
Subclass Beta lactams
Intermediate Tree Nodes Penams
Direct Parent Penicillins
Alternative Parents N-acyl-alpha amino acids and derivatives  Alpha amino acid amides  Phenylacetamides  Aralkylamines  Thiazolidines  Tertiary carboxylic acid amides  Secondary carboxylic acid amides  Amino acids  Azetidines  Thiohemiaminal derivatives  Monocarboxylic acids and derivatives  Azacyclic compounds  Dialkylthioethers  Carboxylic acids  Carbonyl compounds  Hydrocarbon derivatives  Monoalkylamines  Organic oxides  Organopnictogen compounds  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Penicillin - N-acyl-alpha amino acid or derivatives - Alpha-amino acid amide - Alpha-amino acid or derivatives - Phenylacetamide - Aralkylamine - Monocyclic benzene moiety - Benzenoid - Thiazolidine - Tertiary carboxylic acid amide - Amino acid or derivatives - Azetidine - Amino acid - Carboxamide group - Secondary carboxylic acid amide - Azacycle - Carboxylic acid derivative - Carboxylic acid - Monocarboxylic acid or derivatives - Dialkylthioether - Hemithioaminal - Thioether - Primary aliphatic amine - Amine - Organic oxygen compound - Organic nitrogen compound - Carbonyl group - Organopnictogen compound - Organonitrogen compound - Organooxygen compound - Organic oxide - Primary amine - Hydrocarbon derivative - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as penicillins. These are organic compounds containing the penicillin core structure, which is structurally characterized by a penam ring bearing two methyl groups at position 2, and an amide group at position 6 [starting from the sulfur atom at position 1].
External Descriptors hydrate

Associated Targets(Human)

TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
LMNA Tbio Prelamin-A/C (36751 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RECQL Tbio ATP-dependent DNA helicase Q1 (5575 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RUNX1 Tbio Runt-related transcription factor 1/Core-binding factor subunit beta (7867 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Cruzipain (33337 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Streptococcus viridans (303 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Klebsiella pneumoniae (43867 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Micrococcus luteus (7463 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Escherichia coli (133304 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Proteus mirabilis (3894 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Bacillus subtilis (32866 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Bacillus spizizenii (1898 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name (2S,5R,6R)-6-[[(2R)-2-amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;trihydrate
INCHI InChI=1S/C16H19N3O4S.3H2O/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8;;;/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23);3*1H2/t9-,10-,11+,14-;;;/m1.../s1
InChIKey RXDALBZNGVATNY-CWLIKTDRSA-N
Smiles CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=CC=C3)N)C(=O)O)C.O.O.O
Isomeric SMILES CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)[C@@H](C3=CC=CC=C3)N)C(=O)O)C.O.O.O
Molecular Weight 403.45
Reaxy-Rn 54277913
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=54277913&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Chemical and Physical Properties

Sensitivity Heat Sensitive
Specific Rotation[α] 293° (C=0.5,H2O)
Melt Point(°C) 198-200°C
Molecular Weight 403.500 g/mol
XLogP3
Hydrogen Bond Donor Count 6
Hydrogen Bond Acceptor Count 9
Rotatable Bond Count 4
Exact Mass 403.141 Da
Monoisotopic Mass 403.141 Da
Topological Polar Surface Area 141.000 Ų
Heavy Atom Count 27
Formal Charge 0
Complexity 562.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 4
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 4

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Chao Nie, Yunyi Zhao, Pengjie Wang, Ran Wang, Yixuan Li, Xifan Wang, Bing Fang, Xiaoyu Wang, Jing Zhan, Longjiao Zhu, Chong Chen, Weibo Zhang, Haiping Liao, Rong Liu.  (2024)  Momordica charantia Polysaccharide intervention ameliorates the symptoms of dextran sulfate sodium (DSS)-induced colitis by modulating gut microbiota and inhibiting inflammation.  Journal of Functional Foods,  112  (105970). 
2. Jingzhi Yang, Yami Ran, Shaopeng Liu, Chenhao Ren, Yuntian Lou, Pengfei Ju, Guoliang Li, Xiaogang Li, Dawei Zhang.  (2023)  Synergistic D-Amino Acids Based Antimicrobial Cocktails Formulated via High-Throughput Screening and Machine Learning.  Advanced Science,  11  (9): (2307173). 
3. Song Lianjun, Wang Youyi, Li Qingyue, Wang Jinkui, Gao Tian, An Zhaohuan, Liu Qinfang, Mao Yexuan, Bu Tong, Huang Xianqing, Ma Yan, Wang Zhanhui, Zhang Xiya.  (2024)  Production of monoclonal antibody against tylosin and tilmicosin with homogeneous cross-reactivity and its application in lateral flow immunoassay.  MICROCHIMICA ACTA,  191  (1): (1-12). 
4. Bin Deng, Jun Gu, Shuaifeng Zhang, Jin Huang, Xuehan Zhang, Junming Zhou, Wei Wang, Baochao Fan, Jing Liu, Li Li, Mengxiang Su, Bin Li.  (2023)  Low-Cytotoxicity, Broad-Spectrum Corn Starch-Based Antibacterial Particles that Inhibit Multidrug-Resistant Bacteria.  ACS Applied Bio Materials,     
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9. Qianru Gao, Weiyi Tian, Huabing Yang, Haiming Hu, Junping Zheng, Xiaowei Yao, Baifei Hu, Hongtao Liu.  (2023)  Shen-Ling-Bai-Zhu-San alleviates the imbalance of intestinal homeostasis in dextran sodium sulfate-induced colitis mice by regulating gut microbiota and inhibiting the NLRP3 inflammasome activation.  JOURNAL OF ETHNOPHARMACOLOGY,    (117136). 
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11. Lina Fu, Qi Gu, Su Zhang, Jiandong Wang, Zihui Cai, Yujie Fu.  (2023)  Simultaneous extraction and encapsulation of polyphenols from Cajanus cajan leaves and the evaluation of their biological activity.  MICROCHEMICAL JOURNAL,  193  (109187). 
12. Yusheng Gong, Shuai Tong, Xixuan Li, Xiuli Chen, Yushuang Liu, Nan Li, Jiarong Xu, Rengui Xu, Yusong Guo, Fei Xiao, Xiaoyuan Chen, Wei Chen.  (2023)  Intestinal Villi-Inspired Mathematically Base-Layer Engineered Microneedles (IMBEMs) for Effective Molecular Exchange during Biomarker Enrichment and Drug Deposition in Diversified Mucosa.  ACS Nano,  17  (16): (15696–15712). 
13. Meiling Ping, Wenchao Lv, Chen Yang, Qian Chen, Zongwen Wang, Fengfu Fu.  (2023)  A Paper-Based Multicolor Colorimetric Aptasensor for the Visual Determination of Multiple Sulfonamides Based on Aptamer-Functionalized Magnetic Beads and NADH–Ascorbic Acid-Mediated Gold Nanobipyramids.  Chemosensors,  11  (7): (386). 
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18. Mengxue He, Aiyang Liu, Jiachen Shi, Yong-Jiang Xu, Yuanfa Liu.  (2023)  Multi-Omics Reveals the Effects of Cannabidiol on Gut Microbiota and Metabolic Phenotypes.  Cannabis and Cannabinoid Research,     
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26. Yuanping Fang, Congli Chen, Bin Cui, Dandan Zhou.  (2023)  Self-rescue of nitrogen-cycling bacteria under β-lactam antibiotics stress during managed aquifer recharge (MAR): Microbial collaboration and anti-resistance.  WATER RESEARCH,  231  (119623). 
27. Ma Ning, Guo Pingting, Chen Jingyu, Qi Zengkai, Liu Chunchen, Shen Jiakun, Sun Yiwei, Chen Xiyue, Chen Guo-Qiang, Ma Xi.  (2023)  Poly-β-hydroxybutyrate alleviated diarrhea and colitis via Lactobacillus johnsonii biofilm-mediated maturation of sulfomucin.  Science China-Life Sciences,  66  (7): (1569-1588). 
28. Zilu Zhou, Yihan Pu, Wei Liu, Miaomiao Jin, Mo Xian.  (2023)  Assembly and Synthesis Mechanism of CdSe Quantum Dots in Recombinant Escherichia coli Expressing Metallothionein.  ACS Sustainable Chemistry & Engineering,  11  (1): (113–121). 
29. Ke Lan, Huabing Yang, Junping Zheng, Haiming Hu, Tianxiang Zhu, Xiaojuan Zou, Baifei Hu, Hongtao Liu.  (2023)  Poria cocos oligosaccharides ameliorate dextran sodium sulfate-induced colitis mice by regulating gut microbiota dysbiosis.  Food & Function,  14  (2): (857-873). 
30. Xia Liu, Lei Qin, Jie Yu, Wentao Sun, Jianhong Xu, Chun Li.  (2023)  Real-time monitoring of subcellular states with genetically encoded redox biosensor system (RBS) in yeast cell factories.  BIOSENSORS & BIOELECTRONICS,  222  (114988). 
31. Fang Zhou, Elie Kostantin, De-Quan Yang, Edward Sacher.  (2022)  Cytotoxicity and Antibacterial Efficacy of AgCu and AgFe NanoAlloys: A Comparative Study.  Antibiotics-Basel,  11  (12): (1737). 
32. Lei Zhang, Yan Peng, Yue Zhou, Yan Wu, Tao Le.  (2022)  A novel fluorescent probe based on white pitaya peel-derived carbon dots for highly selective and sensitive determination of sulfaquinoxaline in food.  INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY,  58  (2): (631-645). 
33. Xiaoyu Guan, Juntao Guo, Hui Zhang, Shiyong Tao, Gilles Mailhot, Feng Wu, Jing Xu.  (2022)  Effect of Co-Existing Cations and Anions on the Adsorption of Antibiotics on Iron-Containing Minerals.  MOLECULES,  27  (22): (8037). 
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38. Meihua Xi, Yujie Hou, Ruolin Wang, Minhui Ji, Yingying Cai, Jingfang Ao, Heyu Shen, Mei Li, Jun Wang, Anwei Luo.  (2022)  Potential Application of Luteolin as an Active Antibacterial Composition in the Development of Hand Sanitizer Products.  MOLECULES,  27  (21): (7342). 
39. Panpan Li, Yanjun Liu, Juan Zhao, Wenjie Pan, Yuan He, Shunzhe Fu, Yuanfa Liu, Yong-Jiang Xu.  (2022)  Salecan ameliorates liver injury by regulating gut microbiota and its metabolites.  Food & Function,  13  (22): (11744-11757). 
40. Ying Liu, Jingfeng Gao, Mingyan Zhao, Xiaoyu Fu, Yi Zhang, Haoran Zhang.  (2023)  Removal of antibiotic resistant bacteria, genes and inhibition of plasmid-mediated horizontal transfer by peroxymonosulfate: Efficiency and mechanisms.  CHEMICAL ENGINEERING JOURNAL,  453  (139728). 
41. Bu Yiming, Yin Ranhao, Yu Long, Su Pengchen, Li Zibiao, Ye Enyi, Loh Xian Jun, Zhu Houjuan, Wang Suhua.  (2022)  Paper-based device for the selective determination of doxycycline antibiotic based on the turn-on fluorescence of bovine serum albumin–coated copper nanoclusters.  MICROCHIMICA ACTA,  189  (11): (1-10). 
42. Long Bai, Tai Ye, Dongdong Zhu, Donghao Sun, Shuyi Zhang, Yujie Lu, Min Yuan, Hui Cao, Liling Hao, Xiuxiu Wu, Fengqin Yin, Fei Xu.  (2022)  Spherical nucleic acids with tailored DNA conformation via bromide backfilling for the detection of kanamycin.  LUMINESCENCE,  37  (11): (1964-1971). 
43. Jialun Zhong, Nadeem Muhammad, Xiaoying Yang, Jiasheng Li.  (2022)  Antimicrobial, Antioxidant, Anti-Inflammatory Activities of Eight Essential Oils Obtained from Traditional Chinese Medicines Using Supercritical Fluid Extraction Coupled Molecular Distillation.  Journal of Essential Oil Bearing Plants,     
44. Qi Dong, Jingwen Lei, Hanjian Wang, Meifang Ke, Xiao Liang, Xindi Yang, Hui Liang, Céline Huselstein, Zan Tong, Yun Chen.  (2022)  Antibacterial Soy Protein Isolate Prepared by Quaternization.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  23  (16): (9110). 
45. Zhongjia Yu, Xiang-Fang Yu, Goher Kerem, Pei-Gen Ren.  (2022)  Perturbation on gut microbiota impedes the onset of obesity in high fat diet-induced mice.  Frontiers in Endocrinology,  13  (795371). 
46. Zi-Fu Ni, Na Li, Pei Xu, Ze-Wang Guo, Min-Hua Zong, Wen-Yong Lou.  (2022)  Enhancement of thermostability and catalytic properties of ammonia lyase through disulfide bond construction and backbone cyclization.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  219  (804). 
47. Kairong Yang, Pei Jia, Jinjie Hou, Shuang Zhao, Li Wang.  (2022)  An ingenious turn-on ratiometric fluorescence sensor for sensitive and visual detection of tetracyclines.  FOOD CHEMISTRY,  396  (133693). 
48. Xin-Yuan Jiang, Zong-Yi Ren, Nian-Kun Zhang, Ke-Chen Yang, Gao-Xue Wang, Hai-Feng Jiang.  (2022)  Screening and evaluating honokiol from Magnolia officinalis against Nocardia seriolae infection in largemouth bass (Micropterus Salmoides).  JOURNAL OF FISH DISEASES,  45  (11): (1599-1607). 
49. Shaoying Gong, Chaoqin Jiao, Ling Guo.  (2022)  Antibacterial mechanism of beetroot (Beta vulgaris) extract against Listeria monocytogenes through apoptosis-like death and its application in cooked pork.  LWT-FOOD SCIENCE AND TECHNOLOGY,  165  (113711). 
50. Xiaofei Liao, Mengyan Li, Li Zou.  (2022)  Target-induced activation of DNAzyme for highly sensitive colorimetric detection of bleomycin via DNA scission.  RSC Advances,  12  (29): (18296-18300). 
51. Ruihong Yao, Zhijian Li, Panpan Huo, Congcong Gong, Gang Liu, Chunhong Zheng, Shouzhi Pu.  (2022)  L-histidine functionalized ZiF-8 with aggregation-induced emission for detection of tetracycline.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  280  (121546). 
52. Lishan Zhang, Zujie Yao, Huamei Tang, Qingli Song, Huanhuan Song, Jindong Yao, Zhen Li, Xiaofang Xie, Yuexu Lin, Xiangmin Lin.  (2022)  The Lysine Acetylation Modification in the Porin Aha1 of Aeromonas hydrophila Regulates the Uptake of Multidrug Antibiotics.  MOLECULAR & CELLULAR PROTEOMICS,  21  (9):  
53. Yan-Lin Chen, Lan Bai, Dilirebati Dilimulati, Shuai Shao, Che Qiu, Ting Liu, Shuo Xu, Xue-Bing Bai, Lin-Juan Du, Lu-Jun Zhou, Wen-Zhen Lin, Xiao-Qian Meng, Yi-Chao Jin, Yan Liu, Xiao-Hua Zhang, Sheng-Zhong Duan, Feng Jia.  (2022)  Periodontitis Salivary Microbiota Aggravates Ischemic Stroke Through IL-17A.  Frontiers in Neuroscience,  16  (876582). 
54. Jingjing Li, Long Jiang, Xu Wang, Zhixue Zhu, Qingxin Zhang, Su Liu, Yu Wang, Jiadong Huang.  (2022)  Ultrasensitive electrochemical aptasensor based on palindromic sequence mediated bidirectional SDA and a DNAzyme walker for kanamycin detection.  NEW JOURNAL OF CHEMISTRY,  46  (21): (10394-10401). 
55. Bao Jingjiao, Guo Dengkang, Jin Lei, Li Tiejun, Shi Hui.  (2022)  Accurate Identification of Diverse N-acyl Homoserine Lactones in Marine Vibrio fluvialis by UHPLC-MS/MS.  CURRENT MICROBIOLOGY,  79  (6): (1-11). 
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141. Mengyan Wang, Ying Li, Chi Zhang, Gaiping Li, Lina Zou.  (2024)  A signal-on photoelectrochemical aptasensor based on ferrocene labeled triple helix DNA molecular switch for detection of antibiotic amoxicillin.  FOOD CHEMISTRY,  441  (138333). 
142. Tai Ye, Yimin Xu, Haohao Chen, Min Yuan, Hui Cao, Liling Hao, Xiuxiu Wu, Fengqin Yin, Fei Xu.  (2024)  A trivalent aptasensor by using DNA tetrahedron as scaffold for label-free determination of antibiotics.  BIOSENSORS & BIOELECTRONICS,  251  (116127). 
143. Wanling Cui, Yaxian Shao, Mengying Niu, Enguang Lv, Rui Wang, Mei Qiao, Xiaoxin Wang, Zhaohong Qian.  (2024)  Catalytic hairpin assembly-based double-end G-quadruplex signal amplification for sensitive fluorescence detection of kanamycin.  NEW JOURNAL OF CHEMISTRY,     
144. Benke Cui, Chunguang Ren, Renlong Zhang, Yuhang Ren, Jiaxin Liu, Yanzhe Gou, Tianyu Zhao, Xue Jiang, Hongli Cui, Xiuzhi Wang, Linlin Wang.  (2025)  Chlorella-encapsulated living hydrogel based on gelatin and carrageenan with oxygen production, hemostatic and antibacterial capacity for promoting wound healing.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  308  (142356). 
145. Chao Zhang, Tian Tian, Nanzhu Yin, Jingjin Zhao.  (2024)  Click chemistry-based fluorescence polarization sensor for sensitive detection of ampicillin.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  323  (124872). 
146. Xinrui Tang, Abdullah Arsalan, Guoyan Zhang, Junhua Yun, Cunsheng Zhang, Xianghui Qi.  (2025)  Coexpression of D-Allulose 3-Epimerase and L-Rhamnose Isomerase in Bacillus subtilis through a Dual Promoter Enables High-Level Biosynthesis of D-Allose from D-Fructose in One Pot.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,     
147. Alberta Osei Barimah, Shengmei Tai, Chengdong Sun, Tao Ding, Chifang Peng, Minxin Mao, Zhouping Wang, Akwasi Akomeah Agyekum.  (2025)  Colorimetric aptasensor for tobramycin based on a highly stabilized aptamer-enhanced enzyme-mimicking activity of iron oxide/graphene oxide nanospheres.  TALANTA,  285  (127369). 
148. Guocong Luo, Zhaolin Huang, Yingying Zhu, Jiajun Chen, Xiaodong Hou, Dawei Ni, Wei Xu, Wenli Zhang, Yijian Rao, Wanmeng Mu.  (2024)  Crystal structure and structure-guided tunnel engineering in a bacterial β-1,4-galactosyltransferase.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  279  (135374). 
149. Zhenbin Chen, Haohan Cai, Feng Huang, Zongping Wang, Yiqun Chen, Zizheng Liu, Pengchao Xie.  (2024)  Degradation of β-lactam antibiotics by Fe(III)/HSO3− system and their quantitative structure-activity relationship.  ENVIRONMENTAL RESEARCH,  259  (119577). 
150. Yu Peilan, Ji Lintong, Wang Teng, Hu Juan, Jiang Lihao, Guo Shancai, Pan Yongjian, Lin Jianyuan.  (2024)  Detection of Tetracycline in Farm Wastewater by Nitrogen-doped Carbon Quantum Dots.  JOURNAL OF FLUORESCENCE,    (1-10). 
151. Jinping Wang, Jianmin Wu, Zishen Lin, Ning Ma, Zhaoyue Men, Chao Zhang, Xi Ma, Hongyu Zheng.  (2024)  Dietary sodium butyrate and forskolin promote cell proliferation to resist Citrobacter rodentium infection by lysozyme upregulation.  Journal of Functional Foods,  112  (105993). 
152. Zhang Yan, Hua Xia, Han Xiaohu, Fang Xue, Li Peng, Zhai Jingbo, Xie Lin, Lv Yanming, Lai Yonghao, Meng Chengcheng, Zhang Yi, Liu Shiwei, Chen Zeliang.  (2024)  Disruption of Bacterial Biofilms by a Green Synthesized Artemisinin Nano-copper Nanomaterial.  Metallomics,     
153. Yi Hu, Fan-Li Meng, Jia-Heng Zhao, Guo-Ping Sheng.  (2024)  Environmental microbes alleviate antibiotic disturbance on plant endophytes in aquatic microcosms: Prospects for conferring fitness benefits.  WATER RESEARCH,  262  (122112). 
154. Xintong Wang, Yixuan Li, Xifan Wang, Ran Wang, Yanling Hao, Fazheng Ren, Pengjie Wang, Bing Fang.  (2024)  Faecalibacterium prausnitzii Supplementation Prevents Intestinal Barrier Injury and Gut Microflora Dysbiosis Induced by Sleep Deprivation.  Nutrients,  16  (8): (1100). 
155. Haohao Chen, Min Yuan, Fengqin Yin, Hui Cao, Xiuxiu Wu, Liling Hao, Weiyan Shi, Tai Ye, Fei Xu.  (2025)  Freezing-driven assembly of DNA walking machine facilitate G4 nanowires growth for electrochemical detection of kanamycin.  MICROCHEMICAL JOURNAL,  212  (113237). 
156. Chang Liu, Qi Yan, Xuying Ding, Meijun Zhao, Chen Chen, Qian Zheng, Huiying Yang, Yining Xie.  (2024)  Functional modification of recombinant brain-derived neurotrophic factor and its protective effect against neurotoxicity.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  267  (131610). 
157. Chunling Lai, Meiling Huang, Qin Xiong, Yan Liang, Yueming Jiang, Jun Zhang.  (2024)  Green and efficient approach to extract bioactive flavonoids with antioxidant, antibacterial, antiglycation, and enzyme inhibitory activities from navel orange peel.  Sustainable Chemistry and Pharmacy,  38  (101479). 
158. Linping Ma, Jiawen Liu, Xiang Long, Shaogui Wu.  (2025)  Green synthesis of fluorescent carbon dots from waste chicken feathers for chlortetracycline sensing.  JOURNAL OF MOLECULAR STRUCTURE,  1319  (139444). 
159. Hong Xue, Yitian Wang, Chunfeng Mei, Lili Han, Mengxiong Lu, Xuan Li, Ting Chen, Fengyun Wang, Xudong Tang.  (2024)  Gut microbiome and serum metabolome alterations associated with lactose intolerance (LI): a case‒control study and paired-sample study based on the American Gut Project (AGP).  mSystems,     
160. Li Hao, Du Yu, Cheng Kaiwen, Chen Yuxi, Wei Ling, Pei Yujun, Wang Xiaoyu, Wang Lan, Zhang Ye, Hu Xiaoxin, Lu Yi, Zhu Xiangjia.  (2024)  Gut microbiota-derived indole-3-acetic acid suppresses high myopia progression by promoting type I collagen synthesis.  Cell Discovery,  10  (1): (1-14). 
161. Haichuan Zhang, Jiawei Li, Shanshan Ye, Xiyang Zou, Rongxin Fei, Xinyu Hu, Ji Li.  (2024)  High-efficiently utilizing micro-nano ozone bubbles to enhance electro-peroxone process for rapid removal of trace pharmaceutical contaminants from hospital wastewater.  WATER RESEARCH,  259  (121896). 
162. Xu Yuying, Chen Lijuan, Guo Xiaohui, Zhang Jian, Guo Xiaobing, He Ziqian, Zhang Jiani, Han Dongxue.  (2025)  Highly sensitive label-free photoelectrochemical aptasensor based on Cu2MoS4@Ti3C2Tx MXene heterojunction for tetracycline detection in milk.  MICROCHIMICA ACTA,  192  (3): (1-13). 
163. Jiaojiao He, Haoyang Zhou, Jine Liang, Kadireya Tuerxun, Zhuoling Ding, Shishui Zhou.  (2024)  HOM2 Deletion by CRISPR-Cas9 in Saccharomyces cerevisiae for Decreasing Higher Alcohols in Whiskey.  Fermentation-Basel,  10  (11): (589). 
164. Quanliang Li, Xin Wang, Xiyu Wang, Xiaomeng Wang, Dengyi Ye, Ping Chen, Dayong Ren.  (2024)  Hypersensitive colorimetric assay based on microbial inhibition for the detection of multiple antibiotics.  JOURNAL OF FOOD COMPOSITION AND ANALYSIS,  134  (106579). 
165. Meiling Huang, Chunling Lai, Yan Liang, Qin Xiong, Chaoyun Chen, Zhiran Ju, Yueming Jiang, Jun Zhang.  (2025)  Improving the functional components and biological activities of navel orange juice through fermentation with an autochthonous strain Lactiplantibacillus paraplantarum M23.  FOOD AND BIOPRODUCTS PROCESSING,  149  (249). 
166. Fang Xie, Nian Liu, Xiaoqing Liu, Xiaofang Feng, Zhaoxing Yang, Zhijun He, Jie Cai.  (2025)  Insights into folic acid functionalization of self-assembled octenyl succinic anhydride starch micelles towards targeted delivery of selenium nanoparticles.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,    (142352). 
167. Junling Li, Qianru Gao, Hongtao Liu, Songlin Liu, Yanchun Wang, Xiongjie Sun, Junping Zheng, Huabing Yang, Baifei Hu.  (2025)  Integrating 16S rDNA sequencing analysis and targeted metabolomics to explore the mechanism of Xiexin Tang in treating atherosclerosis mice induced by high-fat diet.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,  259  (116760). 
168. Lin Zhang, Siqi Wu, Junfeng Liu, Meiling Ping, Weijuan Yang, FengFu Fu.  (2024)  Isolation of aptamers with excellent cross-reactivity and specificity to sulfonamides towards a ratiometric fluorescent aptasensor for the detection of nine sulfonamides in seafood.  TALANTA,  277  (126380). 
169. Jiaxin Li, Jingna Bao, Yihong Lui, Meiling Chen, Yuqi Chen, Lina Tuolihong, Fuhui Jiang, Shihao Xie, Fengyuan Lyu, Ye Sun, Yan Cao, Huarong Chen, Zhongqing Chen, Zhenhua Zeng.  (2025)  Lentinan enhances microbiota-derived isodeoxycholic acid levels to alleviate hepatic ischemia-reperfusion injury in mice.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,    (140717). 
170. Yang Yang, Yuanji Zhao, Huan Lei, Xiaohong Tan.  (2024)  Limosilactobacillus Fermentun ZS09 Can Improve Antibiotic-Induced Motor Dysfunction in Mice by Regulating the Brain–Gut Functions.  Journal of Inflammation Research,     
171. Xiaoyu Fu, Jingfeng Gao, Qian Wang, Hao Chen, Ying Liu, Liqin Zeng, Yukun Yuan, Hongxin Xu.  (2024)  Mechanisms on the removal of gram-negative/positive antibiotic resistant bacteria and inhibition of horizontal gene transfer by ferrate coupled with peroxydisulfate or peroxymonosulfate.  JOURNAL OF HAZARDOUS MATERIALS,  470  (134254). 
172. Zheng Lei, Jinyong Wu, Caiwen Lao, Jin Wang, Yanyi Xu, He Li, Lixia Yuan, Xiangsong Chen, Jianming Yao.  (2025)  Multistep Metabolic Engineering of Escherichia coli for High-Level Ectoine Production.  ACS Synthetic Biology,     
173. Minghua Xian, Zuqing Ma, Sikai Zhan, Lin Shen, Ting Li, Huiting Lin, Mingmin Huang, Jiale Cai, Tao Hu, Jiaying Liang, Shengwang Liang, Shumei Wang.  (2024)  Network analysis of microbiome and metabolome to explore the mechanism of raw rhubarb in the protection against ischemic stroke via microbiota-gut-brain axis.  FITOTERAPIA,  175  (105969). 
174. Jinghuang Chen, Xianqing Tang, Qihan Sun, Xin Ji, Xingbo Wang, Zhendong Liu, Xu Zhang, Haijiao Xu, Fan Yang, Jian Sun, Xiurong Yang.  (2025)  Nucleotide coordinated polymers, a ROS-based immunomodulatory antimicrobial, doubly kill Pseudomonas aeruginosa biofilms of implant infections.  Bioactive Materials,  44  (461). 
175. Yali Qiao, Yujing Han, Jinfang Shan.  (2024)  One-Pot Synthesis of Ratiometric Fluorescent Europium (III)−Functionalized Polymer Nanodots for Amplified Detection of Tetracyclines.  ACS Applied Nano Materials,  7  (18): (22224-22233). 
176. Zifu Ni, Linshang Zhang, Azhen Nie, Huan Wang, Xiaoling Wu.  (2024)  One-Pot Synthesis of β-Alanine from Fumaric Acid via an Efficient Dual-Enzyme Cascade Biotransformation.  Biomolecules,  14  (12): (1553). 
177. Tong Liu, Yingying Du, Danqi Jiang, Wei Jiang, Lijie Ma, Junjie Wang, Sheng Wang.  (2024)  Partially hydrolyzed guar gum attenuates broad-spectrum antibiotic-induced gut microbiota disruption associated with intestinal inflammation and barrier damage in mice.  Food Bioscience,  61  (104962). 
178. Rilong Liu, Hangzhen Lan, Song Yan, Lu Huang, Daodong Pan, Yichun Wu.  (2024)  Penicillin binding proteins-based immunoassay for the selective and quantitative determination of beta-lactam antibiotics.  ENZYME AND MICROBIAL TECHNOLOGY,  181  (110507). 
179. Senwei Jiang, Hangzhen Lan, Daodong Pan, Lu Huang, Yichun Wu.  (2024)  Penicillin-Binding Proteins and Graphene/Chitosan Nanocomposite-Based Electrochemical Assay for Multiple Beta-Lactam Antibiotics Detection in Milk.  International Journal of Electrochemistry,  2024  (1): (1463794). 
180. Yang Xu, Ge Yan, Jingyu Zhao, Yunhao Ren, Qiyao Xiao, Minhong Tan, Lihua Peng.  (2024)  Plant-derived exosomes as cell homogeneous nanoplatforms for brain biomacromolecules delivery ameliorate mitochondrial dysfunction against Parkinson’s disease.  Nano Today,  58  (102438). 
181. Cunzheng Zhang, Yuzhu Chen, Ruqiao Duan, Yiming Zhang, Haonan Zheng, Jindong Zhang, Tao Zhang, Jingxian Xu, Kailong Li, Fei Pei, Liping Duan.  (2025)  Preconception maternal gut dysbiosis affects enteric nervous system development and disease susceptibility in offspring via the GPR41–GDNF/RET/SOX10 signaling pathway.  iMeta,    (e70012). 
182. Jiachen Li, Xiaoting Dong, Yeli Zhang.  (2024)  Probing the interaction between the metallo-β-lactamase SMB-1 and ampicillin by multispectral approaches combined with molecular dynamics.  JOURNAL OF MOLECULAR RECOGNITION,  37  (5): (e3100). 
183. Shuwen Luo, Huali Li, Min Wu, Yong Tan, Fa-Qian Liu.  (2025)  Promote the controlled-released of Cu ions using galvanic corrosion to achieve high-efficiency antifouling coating.  PROGRESS IN ORGANIC COATINGS,  200  (108990). 
184. Yang Yang, Zhao Yuanji, Lei Huan.  (2024)  Protective effects of Lactococcus lactis subsp. lactis HFY14 supplementation on the brain, intestines, and motor function of antibiotic-treated mice.  Frontiers in Microbiology,  15   
185. Xia Lu, Qinyi Gao, Liqing Xu, Yanxin Ren, Fenfen Tong, Yuxin Wang, Linfan Wang, Na Ge, Wupeng Ge.  (2025)  Rapid Determination of Tetracycline Utilizing a ratiometric fluorescence with Co-Doped Carbon Quantum Dots.  JOURNAL OF FOOD COMPOSITION AND ANALYSIS,    (107252). 
186. Qian Wang, Jingfeng Gao, Hao Chen, Ying Liu, Xiaoyu Fu, Jiawen An, Hanyi Wang, Yuxuan Wang.  (2024)  Removal of antibiotic resistant bacteria by the coupled system of ferrous ion activated peroxymonosulfate (PMS) and sodium percarbonate (SPC): Performance and mechanisms.  CHEMICAL ENGINEERING JOURNAL,  491  (152046). 
187. Cheng Shen, Jiafeng Jin, Ziyan Huang, Meng Meng, Manman Lin, Xiaodan Hu, Qing Zhu, Chongxin Xu, Wei Chen, Johnson Lin, Xiao Zhang, Yuan Liu, Xianjin Liu.  (2024)  Screening and Identification of Anti-Idiotypic Nanobody Capable of Broad-Spectrum Recognition of the Toxin Binding Region of Lepidopteran Cadherins and Mimicking Domain II of Cry2Aa Toxin.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  72  (3): (1582-1591). 
188. Shengxi Zhai, Mengyuan Bai, Fengling Yue, Haifang Wang, Jingcheng Huang, Haowei Dong, Bei Yuan, Zhengtao Li, Pengwei Zhang, Mingxin Zhao, Yemin Guo, Xia Sun, WenPing Zhao.  (2024)  Strip biosensors based on broad-spectrum aptamers and cationic polymers for the on-site rapid detection of tetracycline antibiotics residues in milk.  FOOD CHEMISTRY,    (141743). 
189. Yuan-Yuan Li, Jing-Wen Sun, Lei Chen, Yong-Ming Lu, Qing-Xi Wu, Chao Yan, Yan Chen, Mei Zhang, Wen-Na Zhang.  (2024)  Structural characteristics of a polysaccharide from Armillariella tabescens and its protective effect on colitis mice via regulating gut microbiota and intestinal barrier function.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,    (133719). 
190. Ling Gao, Yue Zhang, Lu Chen, Qingtong Zhou, Nandi Zhou, Xiaole Xia.  (2024)  Study of dual binding specificity of aptamer to ochratoxin A and norfloxacin and the development of fluorescent aptasensor in milk detection.  TALANTA,  273  (125935). 
191. Yunkai Sun, Xiaoxia Wu, Pei Zuo, Zhao Liu, Xuepei Miao, Jian Liu, Hairuo Wen.  (2024)  Synthesis and mutagenic risk of avanafil's potential genotoxic impurities.  RSC Advances,  14  (30): (21432-21438). 
192. He Xiaolong, Hu Mengyao, Xu Yi, Xia Fangbo, Tan Yang, Wang Yuqing, Xiang Huiling, Wu Hao, Ji Tengfei, Xu Qian, Wang Lei, Huang Zhenhe, Sun Meiling, Wan Yu, Cui Peng, Liang Shaocong, Pan Yuan, Xiao Siyu, He Yan, Song Ruixin, Yan Junqing, Quan Xin, Wei Yingge, Hong Changze, Liao Weizuo, Li Fuli, El-Omar Emad, Chen Jinjun, Qi Xiaolong, Gao Jie, Zhou Hongwei.  (2025)  The gut–brain axis underlying hepatic encephalopathy in liver cirrhosis.  NATURE MEDICINE,    (1-12). 
193. Xiuyuan Zhou, Linqing Li, Shengjie Sun, Peng Xiong, Xiutao Liu.  (2025)  The production of succinate with more CO2 fixation reactions facilitated by RuBisCO-based engineered Escherichia coli.  BIOTECHNOLOGY PROGRESS,    (e70015). 
194. Yaozhang Yang, Yuanyuan Wang, Fengyi Zeng, Yuhao Chen, Zhiyi Chen, Fei Yan.  (2024)  Ultrasound-visible engineered bacteria for tumor chemo-immunotherapy.  Cell Reports Medicine,  5   
195. Anqi Sun, Shuo Qi, Yu Li, Yiyao Wu, Yin Zhang, Zhouping Wang.  (2025)  Ultra-stable MAPbBr3@ZIF-8-based fluorescent aptasensor for highly sensitive and specific detection of azlocillin in food.  Food Bioscience,  64  (105920). 
196. Kaineng Huang, Yi He, Xingyu Li, Yuanjiang Pan, Yuanji Gao.  (2024)  Unlocking the Mysteries of the Desorption–Ionization Mechanism via Separate Thermal and Charge Strategies.  ANALYTICAL CHEMISTRY,  96  (48): (19012-19020). 
197. Zhengfeng Guo, Tingting Zhang, Hao Yang, Xiaolin Zhu, Siyuan Lu, Anjie Chen, Mingyu Fan, Jiao Qu.  (2025)  Unraveling tetracycline and its degradation product: Induction mechanisms of antibiotic resistance in Escherichia coli.  SCIENCE OF THE TOTAL ENVIRONMENT,  970  (178959). 
198. Yiwei Sun, Fenjuan Shao, Yuting Luo, Haoxiang Wang, Yuyang He, Liying Sun, Dongpo Xu.  (2024)  ZrO2 Nanofiber-Based Molecular Imprinted Electrochemical Sensor for Detection of Ampicillin.  JOURNAL OF THE ELECTROCHEMICAL SOCIETY,  171  (9): (096507). 

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