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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab190156-100μg
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100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$59.90
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Ab190156-1mg
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1mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$259.90
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Ab190156-5mg
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5mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$669.90
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Ab190156-10mg
|
10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$1,079.90
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Purity≥95% (SDS-PAGE&SEC-HPLC); Endotoxin Level≤1.0EU/mg; Human IgG4SP-Opti-LE; CHO; ELISA, Flow Cytometry, Functional assay, Animal Model; Unconjugated
| Product Name | Amlitelimab (anti-TNFSF4) - Primary antibody, specific to TNFSF4, Human IgG4SP-Opti-LE |
|---|---|
| Synonyms | CD 134L antibody | CD 252 antibody | CD134 ligand antibody | CD134L antibody | CD252 antibody | CD252 antigen antibody | glycoprotein 34 kd antibody | Glycoprotein Gp34 antibody | GP34 antibody | OX-40L antibody | OX40 antigen ligand antibody | OX40 ligan |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Biochemical and Physiological Mechanisms | Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production. |
| Host species | Human |
| Specificity | TNFSF4 |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Product Description |
Amlitelimab (anti-TNFSF4) is a nondepleting human anti-OX40L monoclonal antibody with the potential to treat atopic dermatitis. |
| Isotype | Human IgG4SP-Opti-LE |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 145.94 kDa |
| Purification Method | Protein A purified |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 2378692-15-8 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Amlitelimab (anti-TNFSF4) (Ab190156) - ELISA
Immobilized hu-OX40L-his protein at 2.0 μg/mL can bind Amlitelimab (anti-TNFSF4) (Ab190156) with the EC₅₀ of 14.15 ng/mL.
Amlitelimab (anti-TNFSF4) (Ab190156) - Flow Cytometry
Flow Cytometry analysis of HUVEC cells labelling TNFSF4 (red) with Amlitelimab (anti-TNFSF4) (Ab190156) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Amlitelimab (anti-TNFSF4) (Ab190156) - SEC
The purity of Amlitelimab (anti-TNFSF4) (Ab190156) is more than 95% verified by HPLC.