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Amgen patent anti-ORAI1 (anti-ORAI1) - Primary antibody, specific to ORAI1, Human IgG2SA

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human
  • Isotype: Human IgG2SA
  • Conjugation: Unconjugated
In stock
Item Number
Ab209766
Grouped product items
SKU Size
Availability
Price Qty
Ab209766-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$109.90
Ab209766-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$509.90
Ab209766-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,399.90
Ab209766-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,299.90

Purity≥95% (SDS-PAGE&SEC-HPLC); Endotoxin Level< 0.01EU/μg; Human IgG2SA; CHO; ELISA, Flow Cytometry, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Amgen patent anti-ORAI1 (anti-ORAI1) - Primary antibody, specific to ORAI1, Human IgG2SA
Synonyms Calcium release activated calcium channel protein 1 antibody | Calcium release activated calcium modulator 1 antibody | Calcium release-activated calcium channel protein 1 antibody | CRACM 1 antibody | CRACM1 antibody | CRCM1 antibody | CRCM1_HUMAN antibo
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Biochemical and Physiological Mechanisms Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1. CRAC channels are the main pathway for Ca(2+) influx in T-cells and
Host species Human
Specificity ORAI1
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Product Description

Amgen patent anti-ORAI1 (anti-ORAI1) is a human monoclonal anti-Orai1 antibody (mAb) with the potential to treat autoimmune diseases.

Product Properties

Isotype Human IgG2SA
Light Chain Type lambdaC2
SDS-PAGE 150 kDa
Purification Method Protein A purified
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

ORAI1 Tchem Calcium release-activated calcium channel protein 1 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
ORAI1 Tchem Calcium release-activated calcium channel protein 1 (150 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ORAI1 Tchem ORAI 1/2/3 (82 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ORAI1 Tchem ORAI1/STIM1 (242 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ORAI1 Tchem Short transient receptor potential channel 1 & 3/Stromal interaction molecule 1/Calcium release-activated calcium channel protein 1 (72 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Amgen patent anti-ORAI1 (anti-ORAI1) (Ab209766) - Flow Cytometry
Flow Cytometry analysis of pLVX_Hu_TAM2/ORAI1 cells labelling ORAI1 at 1×105 cell/well can bind Amgen patent anti-ORAI1 (anti-ORAI1) (Ab209766), with the EC50 is 1.529 μg/mL.

Amgen patent anti-ORAI1 (anti-ORAI1) (Ab209766) - SEC
The purity of Amgen patent anti-ORAI1 (anti-ORAI1) (Ab209766) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Solution Calculators

Reviews

Customer Reviews

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